Adiponectin Genetic Variant and Expression Coupled with Lipid Peroxidation Reveal New Signatures in Diabetic Dyslipidemia

Ghoshal, Kakali; Chatterjee, Tanima; Chowdhury, Subhankar; Sengupta, Sanghamitra; Bhattacharyya, Maitree

doi:10.1007/s10528-021-10030-5

Cited by 27 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in subsequent research, adiponectin serum levels were also positively correlated with the sedimentation rate (SR) and CRP levels, which was somewhat puzzling. Previously, the importance of this relationship in the course of psoriasis was unclear, but now it has been demonstrated that plasma adiponectin decreases and CRP increases as metabolic diseases progress [ 44 , 46 , 47 ]. Therefore, the reduction in adiponectin levels is closely related to the occurrence of psoriasis.…”

Section: Adiponectin and Psoriasismentioning

confidence: 99%

“…Adiponectin levels in patients with psoriasis without diabetes are significantly higher than those of patients with progressive diabetes [ 70 ]. Substantially downregulated expression of adiponectin and its receptors in adipose tissues were also linked with diabetic dyslipidaemic conditions [ 47 ]. Experiments have shown that serum insulin levels and the insulin resistance index are positively correlated with the severity of psoriasis [ 118 ].…”

Section: Adiponectin and Psoriasis Comorbiditiesmentioning

confidence: 99%

See 1 more Smart Citation

Adiponectin in psoriasis and its comorbidities: a review

Renju

Zhang

et al. 2021

Lipids Health Dis

View full text Add to dashboard Cite

Psoriasis is a chronic, immune-mediated inflammatory skin disease characterized by abnormal T cell activation and excessive proliferation of keratinocytes. In addition to skin manifestations, psoriasis has been associated with multiple metabolic comorbidities, such as obesity, insulin resistance, and diabetes. An increasing amount of evidence has highlighted the core role of adipokines in adipose tissue and the immune system. This review focus on the role of adiponectin in the pathophysiology of psoriasis and its comorbidities, highlighting the future research avenues.

show abstract

Section: Adiponectin and Psoriasismentioning

confidence: 99%

Section: Adiponectin and Psoriasis Comorbiditiesmentioning

confidence: 99%

Adiponectin in psoriasis and its comorbidities: a review

Renju

Zhang

et al. 2021

Lipids Health Dis

View full text Add to dashboard Cite

show abstract

“…The pattern results from the overproduction of TG-rich very-low-density lipoprotein (VLDL) particles in the liver and increased exchange of TG in VLDL for cholesteryl esters in HDL and LDL-producing sdLDL [ 9 – 11 ]. A complex interaction of genetic and biochemical parameters in diabetic dyslipidemia has also been described [ 12 ]. Decreased serum adiponectin levels, a downregulation in the expression of genes expressing adiponectin such as rs2241766 and rs1501299 and their receptors such as ADIPOR1 and ADIPOR2, and increase levels of oxidative stress have been associated with diabetic dyslipidaemia [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…A complex interaction of genetic and biochemical parameters in diabetic dyslipidemia has also been described [ 12 ]. Decreased serum adiponectin levels, a downregulation in the expression of genes expressing adiponectin such as rs2241766 and rs1501299 and their receptors such as ADIPOR1 and ADIPOR2, and increase levels of oxidative stress have been associated with diabetic dyslipidaemia [ 12 , 13 ]. Furthermore, higher concentrations of biochemical factors such as plasma C-reactive protein and 4-hydroxynonenal adducts have identified as markers of diabetic dyslipidaemia [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

Katundu

Mukhula

Phiri

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Dyslipidaemia drives the process of atherosclerosis, and hence a significant modifiable risk factor complicating hypertension and diabetes. In Malawi, the prevalence, screening and management of dyslipidaemia among persons with diabetes mellitus have not been reported. This study aimed to investigate the prevalence, biochemical characteristics, screening and management practices for dyslipidaemia among persons with diabetes mellitus, hypertension, and diabetes mellitus and hypertension comorbidity at Queen Elizabeth Central hospital in Blantyre, Malawi. Methods This was a cross-sectional study conducted in 2021. A total of 256 adult participants (diabetes mellitus = 100); hypertension = 100; both conditions = 56) were included. Medical data and anthropometric measurements were recorded. Blood samples were analysed for HbA1C and serum lipids. Associated risk factors for dyslipidaemia were also assessed. Results Dyslipidaemia was prevalent in 58%, 55%, and 70% of participants with diabetes mellitus, hypertension, and both conditions. Low-density lipoprotein cholesterol (LDL-C) dyslipidaemia was the most common in all participant groups. Participants with both diabetes and hypertension had 2.4 times (95% CI 1.2–4.6) increased risk of LDL-C dyslipidaemia than those with diabetes alone (p < 0.02). Being overweight or obese and age over 30 years were risk factors for dyslipidaemia in participants with diabetes mellitus alone (OR 1.3 (95% CI 1.1–1.6), p < 0.04, and OR 2.2 (95% CI 1.2–4.7) (p < 0.01), respectively. Overweight and obesity predicted LDL-C dyslipidaemia in hypertensive patients (OR 3.5 (95% CI 1.2–9.9) p < 0.001). Poorly controlled hypertension and the use of beta-blockers and thiazide diuretics predicted dyslipidaemia among patients with both diabetes mellitus and hypertension (OR 6.50 CI 1.45–29.19; and OR 5.20 CI 1.16–23.36 respectively). None of the participants had a lipogram performed before the study or were on lipid-lowering therapy. Conclusions Dyslipidaemia with LDL-C derangement was highly prevalent, especially in individuals with both diabetes mellitus and hypertension, and there was absent use of lipid-lowering therapy. Screening and managing dyslipidaemia should be reinforced to reduce the risk of cardiovascular complications in this population at increased risk.

show abstract

“…This polymorphism is located at the 5′ end of the promoter region of LEP , and it is suggested that this region may contain inhibitory elements from transcription in adipocytes [ 10 ]. The G allele of the ADIPOQ (rs2241766) gene is associated with the risk of hypertension and dyslipidaemia [ 11 , 12 ]. The effect of this variant on pre-mRNA splicing or mRNA stability is well known, suggesting an allele-specific differential expression of adiponectin.…”

Section: Introductionmentioning

confidence: 99%

Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Shramko

Ageeva

Malyi

et al. 2022

Journal of Diabetes Research

View full text Add to dashboard Cite

Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). The purpose of this study was to analyse the frequency with which polymorphic loci of adiponectin (ADIPOQ) and leptin (LEP) genes occur in patients with MS and the association between the symptoms of MS and these polymorphisms. DNA was isolated from the whole blood of 207 patients with MS and 100 healthy individuals (control group) using the phenol-chloroform method. Gene polymorphisms were determined using real-time polymerase chain reaction (PCR). The most common variant of the ADIPOQ (rs2241766) gene among MS patients was the GT genotype. The A allele of the LEP (rs7799039) gene was found to be the most frequent in MS patients. The highest systolic blood pressure was found in carriers of the GG genotype of the LEP (rs7799039) gene. The carriers of the ADIPOQ (rs2241766) GT genotype were associated with the highest systolic blood pressure and body mass index (BMI); carriers of the ADIPOQ (rs2241766) GG genotype were associated with the highest diastolic blood pressure, hyperglycaemia, and elevated glycated haemoglobin (HbA1c). The results of this study allowed us to establish the unique gene variants associated with the risk of developing MS in the Crimean population.

show abstract

Adiponectin Genetic Variant and Expression Coupled with Lipid Peroxidation Reveal New Signatures in Diabetic Dyslipidemia

Cited by 27 publications

References 34 publications

Adiponectin in psoriasis and its comorbidities: a review

Adiponectin in psoriasis and its comorbidities: a review

High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Contact Info

Product

Resources

About