Adiponectin is not associated with renal function decline in community-dwelling elderly adults

Kobayashi, Hiroki; Otsuka, Hiromasa; Yanai, Mitsuru; Haketa, Akira; Hara, Masaaki; Hishiki, Mikano; Abe, Masanori; Soma, Masayoshi

doi:10.1097/md.0000000000010847

Cited by 8 publications

(6 citation statements)

References 48 publications

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“…The leptin levels were quantified using a human leptin radioimmunoassay kit (EMD Millipore Corporation, Billerica, MA) (26). The adipokine adiponectin was measured using a human adiponectin latex kit (LSI Medience Corporation) (27).…”

Section: Blood Analysismentioning

confidence: 99%

Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters

et al. 2021

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Background: Hepcidin-25 is a 25 amino acid hepatokine and a key regulator of iron metabolism related to iron deficiency anemia. Recent studies have suggested that an elevated hepcidin level is correlated with low energy availability. Leptin is an appetite-suppressing adipokine and has been reported to stimulate hepcidin production in animals and cultured cells. While leptin is modulated by exercise, it is known that endurance runners and sprinters practice different types of exercise. This study investigated and compared the relationships between hepcidin and leptin levels, iron status, and body fat to understand better the risk of iron deficiency anemia in endurance runners and sprinters.Methods: Thirty-six male college track and field athletes (15 endurance runners and 21 sprinters) were recruited for this study. Dietary intake, body composition, and blood levels of ferritin, hepcidin-25, leptin, and adiponectin were measured. Correlations between hepcidin levels and ferritin, body fat, leptin, and adiponectin were evaluated using Pearson's correlation coefficient for each group.Results: The endurance runners had lower hepcidin levels and higher leptin and adiponectin levels compared with sprinters. Ferritin was positively correlated with hepcidin-25 levels in both the endurance and sprinter groups. A positive correlation was observed between hepcidin-25 and body fat or leptin levels only in sprinters.Conclusion: This is the first study investigating the relationship between blood levels of hepcidin and leptin in athletes. The positive correlation between hepcidin-25 and leptin was observed in sprinters but not endurance runners.

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Section: Blood Analysismentioning

confidence: 99%

Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters

et al. 2021

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“…Previous epidemiological studies showed inconsistent results in the causal relationship between serum ADPN and eGFR 7‐12 . Traditional epidemiological studies are easily interfered with by confounders, even when these studies adjust for all known confounders, but unknown confounders are difficult to adjust for.…”

Section: Discussionmentioning

confidence: 99%

“…The ADPN may improve eGFR through insulin sensitivity, anti‐atherosclerosis and anti‐inflammatory effects. Some previous epidemiological studies have shown a negative correlation between serum ADPN and eGFR reduction, 7‐10 but this result cannot be verified in other epidemiological studies 11,12 . Therefore, the relationship between serum ADPN level and eGFR remains controversial.…”

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confidence: 93%

Adiponectin affects estimated glomerular filtration rate: A two‐sample bidirectional Mendelian randomization study

et al. 2021

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Background The causal relationship between adiponectin (ADPN) and estimated glomerular filtration rate (eGFR) is unclear. This study adopts a two‐sample bidirectional Mendelian randomization (MR) study to explore the causal relationship between ADPN and eGFR. Methods Using eight single nucleotide polymorphisms (SNP) of ADPN and 26 SNP of eGFR as instrumental variables, the study performs a two‐sample bidirectional MR study using MR inverse‐variance weighted (IVW), MR‐Egger and weighted median approach to evaluate the causal relationship between ADPN and eGFR. Using the genetic risk score (GRS) of ADPN and eGFR as instrumental variables, the study performs a second MR analysis to assess the association between ADPN and eGFR. Results In ADPN to eGFR MR analysis, the IVW, weighted median and GRS analysis all showed that ADPN had a causal effect on eGFR after removing potential confounders of the ADPN‐eGFR relation (IVW: β = .016, P = .002; weighted median: β = .012, P = .022; GRS: β = .016, P = 1.48E‐05). As both ADPN and eGFR were natural log‐transformed in the corresponding GWAS, eGFR increased by 0.15% for any 10% increase in ADPN. In eGFR to ADPN MR analysis, eGFR had no causal effect on ADPN after removing potential confounders of the eGFR‐ADPN relation (All P values > 0.05). The heterogeneity test and sensitivity analysis indicated some heterogeneity, but no directional pleiotropy. Conclusion Adiponectin has a causal effect on eGFR, while eGFR has no causal effect on ADPN. ADPN may be a clinical target for improving eGFR and treating chronic kidney disease caused by decreased eGFR.

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“…Inverse associations were also observed among adiponectin levels and SAT, VAT, total body fat, and lean body mass [ 100 ]. Moreover, studies suggest a negative correlation between adiponectin levels and hand-grip [ 101 ]. Adiponectin may also affect bone turnover.…”

Section: Adipokines and Their Influence On Pathogenesis Nutritional D...mentioning

confidence: 99%

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

et al. 2022

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Obesity is a disease which leads to the development of many other disorders. Excessive accumulation of lipids in adipose tissue (AT) leads to metabolic changes, including hypertrophy of adipocytes, macrophage migration, changes in the composition of immune cells, and impaired secretion of adipokines. Adipokines are cytokines produced by AT and greatly influence human health. Obesity and the pro-inflammatory profile of adipokines lead to the development of chronic kidney disease (CKD) through different mechanisms. In obesity and adipokine profile, there are gender differences that characterize the male gender as more susceptible to metabolic disorders accompanying obesity, including impaired renal function. The relationship between impaired adipokine secretion and renal disease is two-sided. In the developed CKD, the concentration of adipokines in the serum is additionally disturbed due to their insufficient excretion by the excretory system caused by renal pathology. Increased levels of adipokines affect the nutritional status and cardiovascular risk (CVR) of patients with CKD. This article aims to systematize the current knowledge on the influence of obesity, AT, and adipokine secretion disorders on the pathogenesis of CKD and their influence on nutritional status and CVR in patients with CKD.

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Adiponectin is not associated with renal function decline in community-dwelling elderly adults

Cited by 8 publications

References 48 publications

Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters

Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters

Adiponectin affects estimated glomerular filtration rate: A two‐sample bidirectional Mendelian randomization study

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

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