Adiponectin is valuable in the diagnosis of acute heart failure with renal insufficiency

Zhang, Dai; Zhang, Yan; Ye, Huiming; Zhang, Guoqiang; Jin, Hongwei; Chen, Ziming; Yao, Yue; Tian, Xiaobin; Zhou, Jianfeng; Li, Peihua; Liang, Xianming; Xie, Huabing; Ge, Shuping; Zhang, Zhongying

doi:10.3892/etm.2018.6511

Cited by 4 publications

(4 citation statements)

References 52 publications

(57 reference statements)

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“…Recently, the association between NT-proBNP and adiponectin has been examined in adults with heart failure [5,30,31]. Some studies stated that the association of APN and heart failure vanished after adjusting for NT-proBNP [31], some revealed that high APN level was associated with increased risk of mortality, independent of plasma NT-proBNP [22], while Dai Z et al found an improved diagnostic value of conjunction of NT-proBNP and APN for heart failure [30]. While in our study, the diagnostic efficiency of adiponectin for detecting right ventricular dysfunction was not inferior or even probably better than NT-proBNP.…”

Section: Adiponectin and Nt-probnpmentioning

confidence: 99%

High plasma adiponectin is associated with increased pulmonary blood flow and reduced right ventricular function in patients with pulmonary hypertension

et al. 2020

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Background: Adiponectin is a biomarker closely related to heart failure. However, its role in pulmonary hypertension remains unclear. In this study, we investigated the association between adiponectin and hemodynamic abnormalities, right ventricular function in patients with congenital heart disease associated pulmonary hypertension (CHD-PH). Methods: Patients with CHD-PH were enrolled in this cross-sectional study. Linear regression analysis was performed to assess the association between adiponectin, N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) and different clinical parameters. Results were depicted as beta-estimates(ß) with 95%-confidence intervals (95% CI). In addition, mediation and receiver operating characteristic curve analyses were used to analyze the relationships among adiponectin, NT-proBNP and right ventricular function. Results: A total of 86 CHD-PH patients were included. The overall mean adiponectin concentration was 7.9 ± 5.8 μg/ml. Log adiponectin was positively correlated with pulmonary circulation index (ß = 2.2, 95% CI 0.5, 4.0), log NT-proBNP (ß = 0.22, 95% CI 0.04, 0.41) and inversely with the tricuspid annular plane systolic excursion (TAPSE, ß =-4.7, 95% CI-8.6, − 0.8). The mediation analysis revealed the association between NT-proBNP and TAPSE was fully mediated by adiponectin (total effect c = − 5.4, 95% CI-9.4, − 1.5, p = 0.013; direct effect c' = − 3.7, 95% CI-7.5, 0.1, p = 0.067). Additionally, the efficiency of adiponectin for detecting right ventricular dysfunction was not inferior to NT-proBNP (AUC = 0.84, 95% CI 0.67-1.00 vs AUC = 0.74, 95% CI 0.51-0.97, p = 0.23).

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Section: Adiponectin and Nt-probnpmentioning

confidence: 99%

High plasma adiponectin is associated with increased pulmonary blood flow and reduced right ventricular function in patients with pulmonary hypertension

et al. 2020

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“…A meta-analysis by Bai et al suggested that elevated circulating APN levels might be associated with increased all-cause mortality and composite endpoints of death/readmission in patients with acute or chronic HF [ 123 ]. Dai et al demonstrated in clinical trials that APN is a valuable biomarker for acute HF, especially in patients with impaired renal function [ 124 ]. In addition to its application in HF clinical diagnosis, APN can be used for HF prognosis.…”

Section: Role Of Apn In Cardiovascular Disease and Related Advancesmentioning

confidence: 99%

“…[11,[119][120][121] Heart failure Biomarker for diagnosis and prognosis. [123][124][125] A key signal for the role of APN in CVD is AMPK, which plays a key role in regulating anabolic pathways related to energy expenditure by responding to changes in cellular energy status and ATP production/consumption [130], mediating glucose and lipid metabolism, mitochondrial biogenesis, inflammation, oxidative stress, cell proliferation and apoptosis, and cell hypertrophy. AMPK signaling pathway networks should be explored in future studies.…”

Section: Problems and Prospectsmentioning

confidence: 99%

Role of Adiponectin in Cardiovascular Diseases Related to Glucose and Lipid Metabolism Disorders

Han

Yang

Xiao

et al. 2022

IJMS

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Lifestyle changes have led to increased incidence of cardiovascular disease (CVD); therefore, potential targets against CVD should be explored to mitigate its risks. Adiponectin (APN), an adipokine secreted by adipose tissue, has numerous beneficial effects against CVD related to glucose and lipid metabolism disorders, including regulation of glucose and lipid metabolism, increasing insulin sensitivity, reduction of oxidative stress and inflammation, protection of myocardial cells, and improvement in endothelial cell function. These effects demonstrate the anti-atherosclerotic and antihypertensive properties of APN, which could aid in improving myocardial hypertrophy, and reducing myocardial ischemia/reperfusion (MI/R) injury and myocardial infarction. APN can also be used for diagnosing and predicting heart failure. This review summarizes and discusses the role of APN in the treatment of CVD related to glucose and lipid metabolism disorders, and explores future APN research directions and clinical application prospects. Future studies should elucidate the signaling pathway network of APN cardiovascular protective effects, which will facilitate clinical trials targeting APN for CVD treatment in a clinical setting.

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“…The plasma concentration, stability, and diagnostic value of Nt-proANP and Nt-proBNP are higher in patients with chronic HF [ 22 , 23 ]. Studies have shown that the combined determination of adiponectin and NT-proBNP is more accurate than that of NT-proBNP alone [ 24 ]. Other diagnostic biomarkers, such as miR-302b-3p [ 25 ], Soluble ST2 [ 26 ], and Gal-3 [ 27 ], have recently been identified.…”

Section: Introductionmentioning

confidence: 99%

Identification of crucial genes related to heart failure based on GEO database

Chen

Xue

Yan

et al. 2023

BMC Cardiovasc Disord

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Background The molecular biological mechanisms underlying heart failure (HF) remain poorly understood. Therefore, it is imperative to use innovative approaches, such as high-throughput sequencing and artificial intelligence, to investigate the pathogenesis, diagnosis, and potential treatment of HF. Methods First, we initially screened Two data sets (GSE3586 and GSE5406) from the GEO database containing HF and control samples from the GEO database to establish the Train group, and selected another dataset (GSE57345) to construct the Test group for verification. Next, we identified the genes with significantly different expression levels in patients with or without HF and performed functional and pathway enrichment analyses. HF-specific genes were identified, and an artificial neural network was constructed by Random Forest. The ROC curve was used to evaluate the accuracy and reliability of the constructed model in the Train and Test groups. Finally, immune cell infiltration was analyzed to determine the role of the inflammatory response and the immunological microenvironment in the pathogenesis of HF. Results In the Train group, 153 significant differentially expressed genes (DEGs) associated with HF were found to be abnormal, including 81 down-regulated genes and 72 up-regulated genes. GO and KEGG enrichment analyses revealed that the down-regulated genes were primarily enriched in organic anion transport, neutrophil activation, and the PI3K-Akt signaling pathway. The upregulated genes were mainly enriched in neutrophil activation and the calcium signaling. DEGs were identified using Random Forest, and finally, 16 HF-specific genes were obtained. In the ROC validation and evaluation, the area under the curve (AUC) of the Train and Test groups were 0.996 and 0.863, respectively. Conclusions Our research revealed the potential functions and pathways implicated in the progression of HF, and designed an RNA diagnostic model for HF tissues using machine learning and artificial neural networks. Sensitivity, specificity, and stability were confirmed by ROC curves in the two different cohorts.

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Adiponectin is valuable in the diagnosis of acute heart failure with renal insufficiency

Cited by 4 publications

References 52 publications

High plasma adiponectin is associated with increased pulmonary blood flow and reduced right ventricular function in patients with pulmonary hypertension

High plasma adiponectin is associated with increased pulmonary blood flow and reduced right ventricular function in patients with pulmonary hypertension

Role of Adiponectin in Cardiovascular Diseases Related to Glucose and Lipid Metabolism Disorders

Identification of crucial genes related to heart failure based on GEO database

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