Adiponectin levels are associated with the number and activity of circulating endothelial progenitor cells in patients with coronary artery disease

Ying, Zhi-Qiang; Zhong, Danni; Xu, Geng; Chen, Miao-yan; Chen, Qingyu

doi:10.1631/jzus.b0820285

J. Zhejiang Univ. Sci. B

2009

DOI: 10.1631/jzus.b0820285

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Adiponectin levels are associated with the number and activity of circulating endothelial progenitor cells in patients with coronary artery disease

Zhi-Qiang Ying

Danni Zhong

Geng Xu

et al.

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The Role of Adipocytokines in Atherogenesis and Atheroprogression

Carbone

Mach²,

Montecucco³

2015

CDT

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Research investigations on adipose tissue were focused for several decades on its "storage" function. Emerging evidence unveiled adipose tissue as an endocrine organ releasing a several mediators termed as adipokines. Adipokine-mediated functions include both physiological and pathophysiological roles such as regulation of energy metabolism, immune response and vascular homeostasis, as well as inflammatory and metabolic diseases (i.e. atherogenesis, diabetes and obesity clustered in the concept of metabolic syndrome). A dysregulation of adipokine levels has been also suggested as a potential common mechanism underlying these disorders. For instance, an unbalance between pro- and anti-inflammatory adipokines was positively associated with traditional risk factors (dyslipidaemia, hypertension, insulin resistance) in obesity, diabetes and atherogenesis. Adipokine-mediated activities particularly affected endothelial dysfunction/activation and intraplaque inflammation/vulnerability. The purpose of this narrative review is to provide an overview on the role of adipokines in atherogenesis. Evidence from basic research studies about adipokine-induced regulation of vascular and immune cell subsets will be discussed. Finally, conflicting results from clinical trials we be reported, with an attempt to better understand the reason why promising basic research results did not allow a speedy "into human" translation for clinical management of atherogenesis.

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The Role of Adipocytokines in Atherogenesis and Atheroprogression

Carbone

Mach²,

Montecucco³

2015

CDT

View full text Add to dashboard Cite

show abstract

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Adiponectin levels are associated with the number and activity of circulating endothelial progenitor cells in patients with coronary artery disease

Cited by 1 publication

References 31 publications

The Role of Adipocytokines in Atherogenesis and Atheroprogression

The Role of Adipocytokines in Atherogenesis and Atheroprogression

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