Adiponectin Levels in Circulation and Breast Milk and mRNA Expression in Adipose Tissue of Preeclampsia Women

Liu, Yanhua; Zhu, Lijun; Pan, Ya; Sun, Lichao; Chen, Duan; Li, Xiaonan

doi:10.3109/10641955.2010.525273

Cited by 14 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results indicate no differences in insulin and leptin concentrations in colostrum regardless of the influence of the maternal gestational clinical condition, as previously demonstrated for diabetic [ 22 ] and smoking mothers [ 23 , 26 ]. On the other hand, increased adiponectin levels have been observed for hypertensive mothers in comparison to controls, as described by Liu et al [ 27 ]. Higher adiponectin serum and leptin levels in preeclampsia mothers have also been described by other authors [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 64%

See 1 more Smart Citation

Could a remarkable decrease in leptin and insulin levels from colostrum to mature milk contribute to early growth catch-up of SGA infants?

Nunes

Silva

Bosa

et al. 2017

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundBreast milk is known to contain many bioactive hormones and peptides, which can influence infant growth and development. In this context, the purpose of this study was to evaluate the influence of different clinical pregnancy conditions on hormone concentrations in colostrum and mature breast milk.MethodsAn observational study was performed with mother-newborn pairs divided into five groups according to maternal clinical background: diabetes (12), hypertension (5), smoking (19), intrauterine growth restriction of unknown causes with small-for-gestational-age newborns at delivery (12), and controls (21). Socioeconomic data, anthropometric measurements and breast milk samples were collected between the first 24 and 48 h and 30 days postpartum. Leptin, adiponectin, and insulin levels in breast milk were measured by immunoassays.ResultsA significant decrease in leptin (p = 0.050) and insulin (p = 0.012) levels from colostrum to mature breast milk in mothers of small-for-gestational-age infants was observed. Maternal body mass index was correlated with both leptin and insulin, but not with adiponectin. Insulin levels were negatively correlated to infant weight gain from birth to one month (p = 0.050). In addition, catch-up growth was verified for small-for-gestational-age infants throughout the first month of life.ConclusionsThis study suggests that a remarkable decrease in leptin and insulin levels in mature milk of mothers of small-for-gestational-age newborns may be involved in the rapid weight gain of these newborns. The physiological and external mechanisms by which these significant decreases and rapid weight gains occur in this group remain to be elucidated.

show abstract

Section: Discussionmentioning

confidence: 64%

“…However, no such changes have been observed for leptin or other hormones [ 24 , 26 ]. Liu et al, assessed adiponectin concentrations in the breast milk of mothers presenting preeclampsia and observed increases when compared to controls [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Could a remarkable decrease in leptin and insulin levels from colostrum to mature milk contribute to early growth catch-up of SGA infants?

Nunes

Silva

Bosa

et al. 2017

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Ramsay et al [15] reported an elevation of plasma adiponectin concentration in women with PE compared with controls and suggested that adiponectin released during pregnancy could be a physiological response to minimize fat accumulation and also to decrease endothelial damage. However, Liu et al believed that circulating adiponectin levels in PE women might be due to a reduced degradation/elimination rather than an increased synthesis of this adipokine [31]. …”

Section: Discussionmentioning

confidence: 99%

Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia

et al. 2014

View full text Add to dashboard Cite

Aim. This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia. Method. This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA). Results. Maternal serum leptin and adiponectin were significantly higher in PE women than controls. Serum leptin was elevated in early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) compared to controls. Among PE patients, serum leptin was higher in EOPE than LOPE women. However, serum adiponectin was not different between EOPE and LOPE women. The serum leptin was significantly higher in severe PE than mild PE. The serum adiponectin was significantly elevated in severe PE compared to controls. Significant positive correlation was observed between leptin and adiponectin and also between leptin and BMI in controls. Moreover significant positive correlation was observed between adiponectin and BMI in PE patients and controls. Conclusion. The present study showed that serum leptin level may play a significant role as a biomarker to differentiate early and late onset PE and also its relation to BMI and severity of disease.

show abstract

“…In contrast to the consensus in the literature concerning the association between high maternal circulating leptin concentrations and preeclampsia, the evidence regarding maternal adiponectin concentrations in the presence of preeclampsia is inconsistent: higher [38][39][40][42][43][44]47,50,52,[139][140][141][142][143][144][145] , lower 28,[35][36][37][146][147][148][149][150] and similar adiponectin concentrations [151][152][153][154] have been reported in patients with preeclampsia compared to normal pregnant women (Table 4).…”

Section: Maternal Circulating Adiponectin and Complications Of Pregnancymentioning

confidence: 64%

Adipokines and Pathophysiology of Pregnancy Complications – The Role of Leptin and Adiponectin

Mazaki‐Tovi

Vaisbuch

Romero

2013

Fet. Matern. Med. Rev.

View full text Add to dashboard Cite

Adiponectin Levels in Circulation and Breast Milk and mRNA Expression in Adipose Tissue of Preeclampsia Women

Cited by 14 publications

References 35 publications

Could a remarkable decrease in leptin and insulin levels from colostrum to mature milk contribute to early growth catch-up of SGA infants?

Could a remarkable decrease in leptin and insulin levels from colostrum to mature milk contribute to early growth catch-up of SGA infants?

Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia

Adipokines and Pathophysiology of Pregnancy Complications – The Role of Leptin and Adiponectin

Contact Info

Product

Resources

About