Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet

Araki, Hiroshi; Nishihara, Tamao; Matsuda, Morihiro; Fukuhara, Atsunori; Kihara, Shinji; Funahashi, Tohru; Kataoka, Tatsuki R.; Kamada, Y.; Kiyohara, Tatsuya; Tamura, Shinji; Hayashi, Norio; Shimomura, Iichiro

doi:10.1136/gut.2007.135665

Cited by 56 publications

(47 citation statements)

References 33 publications

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“…Also, in our study, rats treated with exendin-4 had lower insulin, adiponectin and leptin levels than control rats. Previous studies have found that adiponectin possibly plays a protective role in acute pancreatitis [21]. In our study, we found that the rats treated with exendin-4 had lower serum adiponectin than control rats, albeit not statistically significant.…”

Section: Effect Of Exendin-4 On Pancreatic Cellssupporting

confidence: 58%

Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

et al. 2009

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Aims/hypothesis Exendin-4 is a 39 amino acid agonist of the glucagon-like peptide receptor and has been approved for treatment of type 2 diabetes. Many reports describe an increased incidence of acute pancreatitis in humans treated with exendin-4 (exenatide). Previous studies have evaluated the effect of exendin-4 on beta cells and beta cell function. We evaluated the histological and biochemical effects of exendin-4 on the pancreas in rats. Methods We studied 20 Sprague-Dawley male rats, ten of which were treated with exendin-4 and ten of which were used as controls. The study period was 75 days. Serum and pancreatic tissue were removed for biochemical and histological study. Blood glucose, amylase, lipase, insulin and adipocytokines were compared between the two groups. Results Animals treated with exendin-4 had more pancreatic acinar inflammation, more pyknotic nuclei and weighed significantly less than control rats. They also had higher serum lipase than control animals. Exendin-4 treatment was associated with lower insulin and leptin levels as well as lower HOMA values than in the untreated control group. Conclusions/interpretation Although the use of exendin-4 in rats is associated with decreased weight gain, lower insulin resistance and lower leptin levels than in control animals, extended use of exendin-4 in rats leads to pancreatic acinar inflammation and pyknosis. This raises important concerns about the likelihood of inducing acute pancreatitis in humans receiving incretin mimetic therapy.

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Section: Effect Of Exendin-4 On Pancreatic Cellssupporting

confidence: 58%

Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

et al. 2009

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“…Furthermore, in AP patients, serum adiponectin levels were inversely correlated with organ dysfunction. However, other studies detected no significant differences in serum adiponectin concentrations [2,3,10,11,12,21]. …”

Section: Discussionmentioning

confidence: 93%

“…It has anti-inflammatory properties in addition to various biological functions, and low serum adiponectin levels are present in obesity [9]. Adiponectin plays a protective role in cerulein-induced AP [6,10,11]. Hypoadiponectinemia could enhance the severity of pancreatitis [12].…”

Section: Introductionmentioning

confidence: 99%

Adipokine Levels in the Course of Mild Biliary Pancreatitis

Demirci¹,

Akbal²,

Koçak³

et al. 2012

Ann Nutr Metab

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Objectives: Obesity markedly increases the risk of severe acute pancreatitis (AP). Several adipokines have been ascribed a role as a predictor of clinical severity in AP. Therefore, the aim of this study was to investigate a possible relationship between leptin and adiponectin and mild biliary AP. Methods: We included 24 consecutive patients with mild biliary AP and 24 consecutive healthy age- and sex-matched controls. Clinical severity was classified by the Ranson score. ELISA was used to assess leptin and adiponectin levels on admission and in remission. Complete blood cell counts and other laboratory tests were also performed at baseline and in remission. Results: Leptin, adiponectin, insulin and HOMA-IR measurements showed no difference in pancreatitis patients both on admission and in remission compared to the control group. No difference was found in leptin, insulin or HOMA-IR levels in the course of pancreatitis. However, adiponectin levels were higher in remission compared to admission. Conclusions: Increased adiponectin levels in remission may be an indication of improvement in this condition. Further studies are needed to determine whether adiponectin provides protection from AP.

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“…Some sections were stained with H&E or sirius red (to visualize collagen deposition) by using standard techniques. Immunostaining for a-SMA and F4/80 was performed as described previously [1], using antibodies against a-SMA (Dakocytomation) and F4/80 (Serotec).…”

Section: Reagentsmentioning

confidence: 99%

“…We reported previously that adiponectin deficiency enhanced the severity of cerulein-induced acute pancreatitis in mice fed a high-fat diet [1]. Moreover, obesity was recently reported to be an independent risk factor for certain pancreatic diseases such as pancreas cancer [2] and acute pancreatitis [3].…”

Section: Introductionmentioning

confidence: 97%

Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice

et al. 2010

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Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet

Abstract: Adiponectin plays a protective role in caerulein-induced AP in HFD-fed mice.

Cited by 56 publications

References 33 publications

Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

Adipokine Levels in the Course of Mild Biliary Pancreatitis

Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice

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