Adipophilin expression is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma: An immunohistochemical analysis

Hashimoto, Yuki; Ishida, Mitsuaki; Ryota, Hironori; Yamamoto, Tomohisa; Kosaka, Hisashi; Hirooka, Satoshi; Yamaki, So; Kotsuka, Masaya; Matsui, Yoshihiko; Yanagimoto, Hiroaki; Tsuta, Koji; Satoi, Sohei

doi:10.1016/j.pan.2019.03.001

Cited by 21 publications

(27 citation statements)

References 18 publications

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“…First, the high expression of ADP is associated with histological aggressiveness and consequently results in a poor prognosis. Lung and pancreatic cancers with high ADP expression often show high-grade morphological features and poor prognosis [13,15]. We found a similar relationship in SDC.…”

Section: Discussionsupporting

confidence: 78%

“…Immunohistochemically, ADP is a diagnostic marker of apocrine differentiation in breast cancer, and lipid-storage cancers such as sebaceous carcinoma and secretory carcinoma of the salivary glands [9][10][11][12]. Furthermore, the ADP expression was recently found to be a poor prognosticator in various malignant tumors, including pulmonary, pancreatic, colonic, and renal cell carcinomas, and Burkitt lymphoma [13][14][15][16][17]. In breast cancer, ADP is related to the ER expression, HER2 status, and the classification based on the biomarker immunoprofiling [9].…”

Section: This Article Is Part Of the Topical Collection On Quality Inmentioning

confidence: 99%

“…Diaminobenzidine was applied to detect antigen-antibody reactions. The ADP expression was considered to be positive when the globular or granular cytoplasmic expression was found in ≥ 5% of the tumor cells, as previously reported [13,15]. FASN was analyzed using a combined scoring system based on both the proportion of positive tumor cells (0-100%) and the predominant staining intensity in the tumor [26].…”

Section: Immunohistochemistry (Ihc) and Fluorescence In Situ Hybridizmentioning

confidence: 99%

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The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma

et al. 2020

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Salivary duct carcinoma (SDC) is an aggressive, uncommon tumor histologically comparable to high-grade mammary ductal carcinoma. SDCs are usually androgen receptor (AR)-positive and often HER2-positive. Recently, therapies targeting these molecules for SDC have attracted attention. Lipid metabolism changes have been described in association with biological behavior in various cancers, although no such relationship has yet been reported for SDC. We therefore analyzed the clinicopathological relevance of the immunohistochemical expression of adipophilin (ADP) and fatty acid synthase (FASN), representative lipid metabolism-related proteins, in 147 SDCs. ADP and FASN were variably immunoreactive in most SDCs (both 99.3%), and the ADP and FASN expression was negatively correlated (P = 0.014). ADPpositive (≥ 5%) SDCs more frequently exhibited a prominent nuclear pleomorphism and high-Ki-67 labeling index than those ADP-negative (P = 0.013 and 0.011, respectively). In contrast, a high FASN score, calculated by the staining proportion and intensity, (≥ 120) was correlated with the high expression of AR and FOXA1 (P < 0.001 and = 0.003, respectively). The ADP and FASN expression differed significantly among the subtypes based on biomarker immunoprofiling, as assessed by the AR, HER2, and Ki-67 status (P = 0.017 and 0.003, respectively). A multivariate analysis showed that ADP-positive expression was associated with a shorter overall and progression-free survival (P = 0.018 and 0.003, respectively). ADP was associated with an aggressive histopathology and unfavorable prognosis, and FASN may biologically interact with the AR signaling pathway in SDC. ADP may, therefore, be a new prognostic indicator and therapeutic target in SDC.

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Section: Discussionsupporting

confidence: 78%

Section: This Article Is Part Of the Topical Collection On Quality Inmentioning

confidence: 99%

Section: Immunohistochemistry (Ihc) and Fluorescence In Situ Hybridizmentioning

confidence: 99%

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The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma

et al. 2020

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“…Consistent with the results in this study, previous studies demonstrated that adipophilin expression was a factor for poor prognosis for several cancers [14,16]. The mechanism involved in adipophilin expression in these cancers remains unclear.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, the presence of clear cytoplasm, eosinophilic cytoplasm, and prominent nucleoli was not associated with adipophilin expression in TNBC. Some previous reports showed that the presence of clear cytoplasm was not associated with adipophilin expression in lung adenocarcinoma and pancreatic ductal adenocarcinoma [14,16].…”

Section: Discussionmentioning

confidence: 83%

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Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma

He,

Liu,

Dong

et al. 2024

Cancer Immunol Immunother

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Background Lipid droplets (LDs) as major lipid storage organelles are recently reported to be innate immune hubs. Perilipin-3 (PLIN3) is indispensable for the formation and accumulation of LDs. Since cancer patients show dysregulated lipid metabolism, we aimed to elaborate the role of LDs-related PLIN3 in oral squamous cell carcinoma (OSCC). Methods PLIN3 expression patterns (n = 87), its immune-related landscape (n = 74) and association with B7-H2 (n = 51) were assessed by immunohistochemistry and flow cytometry. Real-time PCR, Western blot, Oil Red O assay, immunofluorescence, migration assay, spheroid-forming assay and flow cytometry were performed for function analysis. Results Spotted LDs-like PLIN3 staining was dominantly enriched in tumor cells than other cell types. PLIN3high tumor showed high proliferation index with metastasis potential, accompanied with less CD3+CD8+ T cells in peripheral blood and in situ tissue, conferring immunosuppressive microenvironment and shorter postoperative survival. Consistently, PLIN3 knockdown in tumor cells not only reduced LD deposits and tumor migration, but benefited for CD8+ T cells activation in co-culture system with decreased B7-H2. An OSCC subpopulation harbored PLIN3highB7-H2high tumor showed more T cells exhaustion, rendering higher risk of cancer-related death (95% CI 1.285–6.851). Conclusions LDs marker PLIN3 may be a novel immunotherapeutic target in OSCC.

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Adipophilin expression is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma: An immunohistochemical analysis

Cited by 21 publications

References 18 publications

The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma

The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma

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Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma

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