Adipose-derived mesenchymal stem cells slow disease progression of acute-on-chronic liver failure

Gilsanz, Carlos; Aller, María-Ángeles; Fuentes‐Julian, Sherezade; Prieto, I.; Blázquez-Martínez, Alejandro; Argudo, Salvador; Fernandez‐Delgado, Jorge; Beleña, José M.; Árias, Jaime; Miguel, María P. De

doi:10.1016/j.biopha.2017.04.117

Cited by 24 publications

(26 citation statements)

References 57 publications

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“…[3][4][5] Due to the limited available treatments for reversing RIF, it remains a reconstructive challenge for the surgical field. [19][20][21][22][23] Despite, the multiple references that lipotransfer may reverse fibrosis and provide volume restoration, only a few recent studies have evaluated their use in the reversal of fibrosis and volume loss following head and neck reconstruction. [8][9][10] Lipotransfer is considered a useful tool for enhancing the residual contour deformities following free flap reconstruction.…”

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confidence: 99%

“…Although the mechanism by which the lipotransfer reverses the fibrosis is unclear, current research is focusing on establishing the effect of the ADSCs within the lipotransfer on several fibrotic conditions. [19][20][21][22][23] Despite, the multiple references that lipotransfer may reverse fibrosis and provide volume restoration, only a few recent studies have evaluated their use in the reversal of fibrosis and volume loss following head and neck reconstruction. This study retrospectively reports on the effectiveness of lipotransfer for the treatment of RIF and volume restoration following head and neck cancer in thirty-eight patients.…”

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confidence: 99%

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Evaluation of the efficacy of lipotransfer to manage radiation‐induced fibrosis and volume defects in head and neck oncology

et al. 2019

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Background Multimodality treatment for head and neck cancer leads to substantial functional and esthetic impairment mainly manifested as radiation‐induced skin fibrosis (RIF) in combination with volumetric defects and reduction in neck mobility. This study assessed the impact of lipotransfer as part of secondary surgical procedure(s) in patients treated for head and neck malignancies. Methods Retrospective analysis was performed between 2005 and 2016. All patients with a history of head and neck malignancy, multimodal treatment including at least surgery or radiotherapy, and at least 2‐year disease‐free survival were included. Thirty‐eight patients (22 men, 16 women) matched the inclusion criteria. Results Thirty seven (97%) reported esthetic and functional improvements in their RIF and volumetric defect at follow‐up of 32 months. Major improvement in esthetic and functional outcome was reported by 24 (63%) patients and surgeons and minor by 13 patients and surgeons (34%) without causing any complications. Lipotransfer was also found to significantly improve patient's psychological health postoperatively as showed by significant improvements in Derriford Appearance Scale (DAS24), Short Form Health Survey (SF‐36), and University of Washington Quality of Life Questionnaire (UW‐QOL V4) scores (P < .001). Conclusions Lipotransfer is effective for volume restoration and treating scar and RIF from head and neck defects.

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confidence: 99%

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confidence: 99%

Evaluation of the efficacy of lipotransfer to manage radiation‐induced fibrosis and volume defects in head and neck oncology

et al. 2019

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“…Many previous studies have shown that MSC transplantation can improve liver function, inhibit hepatocyte apoptosis, and promote hepatocyte proliferation in animal models of ALF [ 19 , 36 , 47 – 51 ]. Cai et al established that BM-MSC transplantation decreased ALT and AST levels, downregulated Bax protein, and increased Bcl-2 expression compared with an acute liver injury (ALI) model [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, another study suggested that the liver function of rats with liver failure was significantly improved after MSC transplantation via three different routes, namely the hepatic artery, portal vein, and peripheral vein, but no significant difference was observed among the three groups [ 68 ]. There was no significant difference in liver enzyme, albumin, bilirubin, and hemoglobin levels; total white blood cell count; and platelets in patients with liver failure treated via intrahepatic and intrasplenic injection of MSCs [ 47 , 69 ]. In addition, UC-MSC transplantation through the peripheral vein displayed similar curative effects with intrahepatic injection [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Progress in mesenchymal stem cell–based therapy for acute liver failure

Wang

Chen

et al. 2018

Stem Cell Res Ther

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Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. Several types of stem cells have been used to study liver diseases; mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure.

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“…It has been shown that stem cells can promote the regeneration of impaired organs, tissues and cells through ‘cell replacement’ or the ‘paracrine effect’ ([ 4 , 5 , 53 ]; Jinglin et al, 2017; [ 7 , 45 ]). As one of the adult stem cells, human adipose-derived stem cells (hASCs) are characterized by a high multiplication rate, broad differentiation potency and relatively easy accessibility, for which they are expected to be ideal seed cells for the treatment of some severe liver diseases such as acute liver failure (ALF) [ [8] , [9] , [10] ].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19

Jin

Wang²,

Li³

et al. 2018

EBioMedicine

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It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a ‘paracrine effect’. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown by the improvement of the survival rate by >70% compared to controls. Gene sequencing of rat liver revealed an increase in human long-chain non-coding RNA (lncRNA) H19 after hASC-derived EVs transplantation. When the H19 coding sequence was silenced in hASCs and EVs were then collected for treatment of rats with liver failure, we saw a decrease in the survival rate to 40%, compared to treatment with EVs generated from non-silenced hASCs. These data indicate that lncRNA H19 may be a potential therapeutic target for the treatment of liver failure.

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Adipose-derived mesenchymal stem cells slow disease progression of acute-on-chronic liver failure

Cited by 24 publications

References 57 publications

Evaluation of the efficacy of lipotransfer to manage radiation‐induced fibrosis and volume defects in head and neck oncology

Evaluation of the efficacy of lipotransfer to manage radiation‐induced fibrosis and volume defects in head and neck oncology

Progress in mesenchymal stem cell–based therapy for acute liver failure

Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19

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