Adipose-Derived Mesenchymal Stem Cells With Microfracture Versus Microfracture Alone: 2-Year Follow-up of a Prospective Randomized Trial

Koh, Yong‐Gon; Kwon, Ohchan; Kim, Yong−Sang; Choi, Yeonho; Tak, Dae-Hyun

doi:10.1016/j.arthro.2015.09.010

Cited by 230 publications

(221 citation statements)

References 43 publications

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“…The first group received adipose derived stem cells with fibrin glue and micro fracture treatment whereas the second group received micro fracture treatment alone. The group that received stem cells and micro fracture with fibrin glue had improved radiologic, pain and symptom scores with no differences in activity, sports, or quality-of-life scores in comparison to the other group [78].…”

Section: Osteoarthritismentioning

confidence: 97%

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Adipose Tissue-Derived Mesenchymal Stem Cells: A Novel Therapy in Orthopedics

2018

J Orthopedics Rheumatol

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Background: Mesenchymal stem cells can differentiate into a variety of cell types. They have the ability to release bioactive molecules, making them attractive tools in cell-based therapies. Adipose tissue is an ideal source of autologous mesenchymal stem cells for its abundance and easy access. Mesenchymal stem cells are routinely obtained enzymatically from lipoaspirate as stromal vascular fraction.Objectives: The aim of this review is to investigate the advantages of adipose derived stem cells in orthopedic application. Methods:Randomised controlled trials (RCTs) and non-RCTs, in addition to cohort and case control studies, as well as case series were included. Search language was restricted to English and time starting from year 2012. Only published papers were eligible.Results: Thirteen articles were included in the review, they consisted of 1 RCT, 4 nRCTs, 1 prospective comparative study, 1 longitudinal cohort study, 2 case control studies, 3 case series and one case report. The number of patients injected with stem cells ranged between 12 and 1128. A total of 1482 patients were treated with adipose derived stem cells Conclusion:The use of adipose derived stem cells had shown to be safe and effective in bone and cartilage repair.

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Section: Osteoarthritismentioning

confidence: 97%

“…Thirteen articles were included in the review, they consisted of 1 RCT, 4 nRCTs, 1 prospective comparative study, 1 longitudinal cohort study, 2 case control studies, 3 case series and one case report [68,[73][74][75][76][77][78][79][80][81][82][83][84]. The number of patients injected with stem cells ranged between 12 and 1128.…”

Section: Study Characteristicsmentioning

confidence: 99%

Adipose Tissue-Derived Mesenchymal Stem Cells: A Novel Therapy in Orthopedics

2018

J Orthopedics Rheumatol

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“…[38] 2016'da yayınladıkları çalımada; sadece metotreksat (MTX) tedavisi ve fibrin yapıtırıcıyla AD-MKH ve MTX tedavisi karılatırılmıtır. Üçüncü 12. ve 24. ayında izlenen hastalarda a¤rı ve semptomlarda AD-MKH infüze edilen hasta gruplarında di¤erlerine göre artan bir iyileme varken, artroskopi sırasında alınan biyopsiler ve di¤er alt skorlarda (günlük/rekreasyon aktivite, spor, yaam kalitesi) her iki grupta da baarılı bir yenilenme kaydedilmi olup gruplar arası anlamlı bir farklılık tespit edilememitir.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

“…Üçüncü 12. ve 24. ayında izlenen hastalarda a¤rı ve semptomlarda AD-MKH infüze edilen hasta gruplarında di¤erlerine göre artan bir iyileme varken, artroskopi sırasında alınan biyopsiler ve di¤er alt skorlarda (günlük/rekreasyon aktivite, spor, yaam kalitesi) her iki grupta da baarılı bir yenilenme kaydedilmi olup gruplar arası anlamlı bir farklılık tespit edilememitir. [38] Osteogenesis imperfecta (OI) tedavisinde MKH kullanımı üzerine prenatal ve postnatal klinik çalımalar yapılmaktadır. OI; COL1A1 ya COL1A2 genlerinde 1500 farklı dominant mutasyondan kaynaklanan kollajen sentezi bozuklu¤unun neden oldu¤u genetik bir hastalık-tır.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

Stem cells; mesenchymal stem cells and current clinical applications

Tekeli¹

2016

FNG & Bilim Tıp Transplantasyon Dergisi

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Stem cells are defined as a type of cell that have the features of self-renewal, unlimited proliferation capacity, potential of differentiation into other cell types and ability to repair damaged structure when given to damaged tissue. Stem cells are preferred for regenerative medical applications because of their abundance, being easily obtained, ability to proliferate by differentiating into many cell types and being transplantable safely and effectively to recipients. In this review, we introduce mesenchymal stem cells as one of the most important sources of stem cells that have clinical applications and give examples of their usage areas in the clinic and of studies.Keywords: Clinical application; mesenchymal stem cells; stem cell. Stem cells; mesenchymal stem cells and current clinical applications ÖZKök hücreler; kendilerini yenileyebilme, sınırsız çoğalabilme, kendilerinden başka hücrelere farklılaşabilme, hasarlı dokuya verildiğinde hasarlı yapıyı onarabilme özellikleri ile tanımlanan hücre tipidir. Kök hücreler bol miktarda bulunmaları, kolay elde edilebilmeleri, birçok hücre tipine farklılaşarak çoğalabilmeleri, alıcılara güvenli ve etkin bir şekilde nakledilebilmeleri nedeniyle rejeneratif tıp uygulamalarında tercih edilmektedir. Bu derlemede, klinikte uygulamaları bulunan ve en önemli kök hücre kaynaklarından biri olan mezenkimal kök hücreler tanıtılacak, klinikteki kullanım alanları ve çalışmalardan örnekler verilecektir.

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“…Recently, the use of autologous PRP coupled with the microfracture technique has been associated with beter short-term clinical and functional outcomes, especially in pain [131][132][133]; in addition, arthroscopic implantation of AD-MSC combined with the microfracture technique has also been associated with a decrease in pain [134]. Similarly, the use of AD-MSC [135,136] or BM-MSC [137,138] has been reported as a safe therapeutic alternative via intraarticular injection in patients with osteoarthritis, which report a signiicant improvement in pain levels.…”

Section: The Eicacy and Safety Of Diferent Treatments Of Cartilage Inmentioning

confidence: 99%

Current Applications of Mesenchymal Stem Cells for Cartilage Tissue Engineering

Fuentes-Mera¹,

Camacho²,

Moncada‐Saucedo³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Articular cartilage injuries caused by traumatic/mechanical progressive degeneration result in joint pain, swelling, the consequent loss of joint function, and eventually osteoarthritis. Articular tissue possesses a poor ability to regenerate that further complicates the therapeutic approaches. Mesenchymal stem cells (MSCs) have emerged as a promising alternative treatment. Recently, it has been reported that a wide variety of strategies ranging from merely using cells in the injured area to employ biofunctional substitutes in which cells are harmonizing with scafolding and growth factors to create an engineered cartilage tissue.This chapter reviews the state-of the-art in cartilage tissue engineering focused on tissue engineering approaches designed to recapitulate the native development of cartilage and its tridimensional structure as an osteochondral unit. Since the production of hypertrophied tissue is one of the most critical challenges to overcome in chondral tissue regeneration, here we show new strategies to minimize hypertrophy in cartilage. Finally, the eicacy and safety of diferent treatments of cartilage in current clinical trials will be discussed.While the framework provides new features and beneits concerning the strategies for articular tissue regeneration, this chapter presents a set of tools to improve approaches to orthopedic regenerative medicine based on the use of MSCs.Keywords: MSCs, MSCs-subpopulations, cartilage regeneration, cartilage tissue engineering, hypertrophy © 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. IntroductionThe chondrocytes are the only cells found in cartilage. The chondrocytes demonstrate distinctive properties such as being metabolically active in order to maintain the renewal of the extracellular matrix (ECM) by synthesizing collagens, proteoglycans, hyaluronic acid, and glycoproteins. Restoration of the cartilage damage is still challenging for orthopedic medicine due to its poor ability to regenerate [1].Mesenchymal stem cells (MSCs) have potential applications in tissue engineering, and regenerative medicine represents an atractive option for repairing lesions in cartilage. Stem cellbased therapies that harmonize with tissue-engineering technologies, and biomaterials are vital for the continuous advance of cartilage regenerative medicine [2,3].Once the relationship between structure function in normal and damaged tissues is understood and the development of biological substitutes for the repair or regeneration can be reached. To develop a biological substitute, tissue engineering uses scafolds, cells, and growth factors. Each of these elements alone is able to promote tissue regeneration, but composites fabricated in combination would be more efective [4,5].The objective of the present chapter is, therefore, t...

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Adipose-Derived Mesenchymal Stem Cells With Microfracture Versus Microfracture Alone: 2-Year Follow-up of a Prospective Randomized Trial

Cited by 230 publications

References 43 publications

Adipose Tissue-Derived Mesenchymal Stem Cells: A Novel Therapy in Orthopedics

Adipose Tissue-Derived Mesenchymal Stem Cells: A Novel Therapy in Orthopedics

Stem cells; mesenchymal stem cells and current clinical applications

Current Applications of Mesenchymal Stem Cells for Cartilage Tissue Engineering

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