2012
DOI: 10.1136/gutjnl-2012-302152
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Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis

Abstract: ASCs induce a distinct regulatory activation state of macrophages which possess potent immunomodulatory ability and therapeutic potential in inflammatory bowel diseases and sepsis.

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Cited by 186 publications
(177 citation statements)
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“…In our present study, we were able to reproduce our results with the 5 dose protocol of The mechanisms of action hypothesized for MSCs anti-inflammatory properties have been investigated in many studies [55][56][57][58][59][60]. aMSCs showed enhanced anti-inflammatory IL-10 secretion [73] together with decreased pro-inflammatory TNF-α, INF-γ, IL-1β and their downstream effects on various elements of the immune system.…”
Section: Discussionsupporting
confidence: 74%
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“…In our present study, we were able to reproduce our results with the 5 dose protocol of The mechanisms of action hypothesized for MSCs anti-inflammatory properties have been investigated in many studies [55][56][57][58][59][60]. aMSCs showed enhanced anti-inflammatory IL-10 secretion [73] together with decreased pro-inflammatory TNF-α, INF-γ, IL-1β and their downstream effects on various elements of the immune system.…”
Section: Discussionsupporting
confidence: 74%
“…Regarding the mechanism of action of MSCs, as stated earlier, researchers are suggesting that, the therapeutic benefits of MSCs in RORM might be mediated by their paracrine effects with or without homing to the injury site, rather than their differentiation properties replacing the damaged cells [55,70,71,195,196].…”
Section: Chapter 7 Discussionmentioning
confidence: 99%
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“…MSCs are stromal cells that can be harvested from bone marrow, adipose tissue, and umbilical cords [26][27][28]. These cells have been regarded as prospective therapeutic tools because of their characteristics, such as multipotent differentiation, self-renewal, immunomodulation, and immunoprivilege [29].…”
Section: Discussionmentioning
confidence: 99%