Adipose-derived stem cells induced dendritic cells undergo tolerance and inhibit Th1 polarization

Human adipose-derived stromal cells in a clinically applicable injectable alginate hydrogel: Phenotypic and immunomodulatory evaluation

“…This indicates that ASC suppression of DC maturation is contact dependent. The same immunomodulatory effect on DCs was found by Liu et al with MSCs [41] and Peng et al with ASCs [42]. The significance of contact for this modulation is supported by Larocca et al observing ASCs and DCs co-cultured in a Transwell systems [43].…”

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

“…Furthermore, ASC-mediated immunosuppression has been observed in numerous in vitro experiments utilizing the gold-standard mixed lymphocyte reaction (MLR) system [335][336][337][338]. More recently, dendritic cells cocultured with ASCs and then cultured with CD4+ T cells have been found to inhibit T cell activation, suggesting that the dendritic cells' ability to mediate immunity has been altered through its exposure to ASCs [339]. With regards to in vivo model systems, reduced inflammatory infiltration and airspace enlargement results upon the systemic administration of human ASCs to murine models of emphysema.…”

Transplantation of Adipose-Derived Stem Cells in Stroke

“…Consistently, coculturing ADSC with allogeneic dendritic cells revealed that ADSC could negatively modulate immunity and induce immune tolerance through downregulating costimulatory molecules (i.e., CD80, CD83, CD86, and secretion of IL-12 and tumor necrosis factor (TNF)-alpha), while induce dendritic cell tolerance through upregulating indoleamine-2,3-dioxygenase (IDO). Cocultured dendritic cells were also found to inhibit CD4+ T cell activation and naive T cells toward Th1 helper cell polarization (Peng et al 2012). Again, another credit given to ADSC as compared with bone marrow-derived mesenchymal stem cells in the aspect of immunomodulation in stroke treatment is the finding of a higher immunomodulatory capacity in the former than that in the latter (Melief et al 2013b).…”