Adipose-derived stem cells on the healing of ischemic colitis: a therapeutic effect by angiogenesis

Abstract

Local implantation of ASCs into an ischemic-injured colonic wall reduced the grade of ischemic injury and enhanced tissue healing by promoting angiogenesis.

Long-term MRI tracking of dual-labeled adipose-derived stem cells homing into mouse carotid artery injury

“…22 ADSCs can be used autologously without breaching any ethical standards. 23 In this study, passage 3 GFP-ADSCs were positive for CD90 and CD105, but negative for CD11b, CD31, CD34, CD83, and CD133. Passage 3 GFP-ADSCs also have the ability to differentiate into a number of mesodermal lineages, including osteoblasts, adipocytes, and chondrocytes, which is consistent with previous reports.…”

“…7,23 Direct comparisons between ADSCs and bone marrow stem cells immune phenotypes reveal that they are 90% identical. 21 ADSCs have a stronger proliferation ability and multidifferentiation potential than bone marrow stem cells.…”

Stem Cell Therapy in the Treatment of Inflammatory Bowel Disease

“…Preclinical studies on the models of necrotizing colitis as well as experimental colitis induced by DSS and 2,4,6-TNBA showed positive effect of systemic and local use of MSC derived from the bone marrow, amniotic fluid, cord blood, adipose tissue on the course of colitis and stimulation of reparation [15,16,19,26]. CT was shown to increase survival and stimulate reparation of the damaged mucous membranes of the large intestine of newborn rats with necrotizing colitis.…”

“…SC derived from bone marrow, peripheral and cord bloods, tissue of umbilical cord, amniotic fluid, adipose tissue have got wide use [4,16,17,19]. Remedial effect of SC is explained both by paracrine effectstimulation of regenerative processes through the synthesis of growth factors and other biologically active compounds and ability to transformation into damaged tissues cells [14,17,18,20,21].…”

“…Another mechanism of therapeutic effect of MSC is their prominent regenerative effect as these cells are the precursors of the connective tissue [14,15,19]. MSC were revealed to release numerous trophic factors (VEGF, EGF etc) and affect all stages of the complex process of wound healing -inflammatory, proliferative and tissue remodeling [21].…”