Adipose Tissue Density, a Novel Biomarker Predicting Mortality Risk in Older Adults

Murphy, Rachel A.; Register, Thomas C.; Shively, Carol A.; Carr, J. Jeffrey; Ge, Yaorong; Heilbrun, Marta E.; Cummings, Steven R.; Koster, Annemarie; Nevitt, Michael C.; Satterfield, Suzanne; Tylvasky, Frances A.; Strotmeyer, Elsa S.; Newman, Anne B.; Simonsick, Eleanor M.; Scherzinger, Ann; Goodpaster, Bret H.; Launer, Lenore J.; Eiríksdóttir, Guðný; Sigurðsson, Sigurður; Sigurðsson, Gunnar; Gudnason, Vilmundur; Lang, Thomas; Kritchevsky, Stephen B.; Harris, Tamara B.

doi:10.1093/gerona/glt070

Cited by 96 publications

(148 citation statements)

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“…More recently, Fox et al 12 examined associations between SAT and VAT attenuation values and cardiometabolic risk factors. They found that low CT attenuation of both VAT and SAT 13 was associated with an adverse cardiometabolic risk profile, independent of total adiposity. In 2014, Murphy et al 13 have shown that SAT and VAT attenuation values were good markers of mortality risk in older adults, independent of CRP and IL-6 levels.…”

Section: Introductionmentioning

confidence: 99%

“…They found that low CT attenuation of both VAT and SAT 13 was associated with an adverse cardiometabolic risk profile, independent of total adiposity. In 2014, Murphy et al 13 have shown that SAT and VAT attenuation values were good markers of mortality risk in older adults, independent of CRP and IL-6 levels. However, the reason for the relationship between adipose tissue attenuation and cardiometabolic risk is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Computed tomography-measured adipose tissue attenuation and area both predict adipocyte size and cardiometabolic risk in women

et al. 2015

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Objective: To assess the ability of CT-derived measurements including adipose tissue attenuation and area to predict fat cell hypertrophy and related cardiometabolic risk. Methods: Abdominal adipose tissue areas and radiologic attenuation were assessed using 4 CT images in 241 women (age: 47 years, BMI: 26.5 kg/m 2 ). Fat cell weight was measured in paired VAT and SAT samples. Fasting plasma lipids, glucose and insulin levels were measured. Results: Adipose tissue attenuation was negatively correlated with SAT (rD-0.46) and VAT (rD-0.67) fat cell weight in the corresponding depot (p<0.0001 for both). Women with visceral adipocyte hypertrophy had higher total-, VLDL-, LDL-and HDL-triglyceride and apoB levels as well as a higher cholesterol/HDL-cholesterol ratio, fasting glucose and insulin levels compared to women with smaller visceral adipocytes. Adjustment for VAT area minimized these differences while subsequent adjustment for attenuation eliminated all differences, with the exception of fasting glycaemia. In SAT, adjustment for VAT area and attenuation eliminated all adipocyte hypertrophy-related alterations except for fasting hyperglycaemia. Conclusion: CT-derived adipose tissue attenuation and area both contribute to explain variation in the cardiometabolic risk profile associated with the same biological parameter: visceral fat cell hypertrophy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Computed tomography-measured adipose tissue attenuation and area both predict adipocyte size and cardiometabolic risk in women

et al. 2015

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“…Recently, however, computed tomography-determined adipose-tissue density in the visceral and subcutaneous depots, which correlates with smaller adipocyte size and higher adiponectin concentrations, was shown to be an independent predictor of mortality in two older cohorts (26). Whether the positive association of adiponectin with mortality is independent of adipose-tissue density has not been reported, but would address the role of changes in adipocyte size and function as an underpinning in aging, and perhaps other disorders such as HF.…”

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confidence: 99%

Adiponectin, cardiovascular disease, and mortality: Parsing the dual prognostic implications of a complex adipokine

Kizer

2014

Metabolism

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“…A very recent study showed that lower density tissue determined from computed tomography imaging, an indication of greater fat content, was associated with less mortality (9). Another hypothesis is that BMI is a poor proxy for excess body fat and does not capture nuances of fat storage (10).…”

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Obesity and 10-Year Mortality in Very Old African Americans and Yoruba-Nigerians: Exploring the Obesity Paradox

Clark¹,

Gao

Lane

et al. 2014

The Journals of Gerontology: Series A

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Adipose Tissue Density, a Novel Biomarker Predicting Mortality Risk in Older Adults

Abstract: VAT and SAT density provide a unique marker of mortality risk that does not appear to be inflammation related.

Cited by 96 publications

References 29 publications

Computed tomography-measured adipose tissue attenuation and area both predict adipocyte size and cardiometabolic risk in women

Computed tomography-measured adipose tissue attenuation and area both predict adipocyte size and cardiometabolic risk in women

Adiponectin, cardiovascular disease, and mortality: Parsing the dual prognostic implications of a complex adipokine

Obesity and 10-Year Mortality in Very Old African Americans and Yoruba-Nigerians: Exploring the Obesity Paradox

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