Adipose Tissue-Derived Regenerative Cells Improve Implantation of Fertilized Eggs in Thin Endometrium

Yotsumoto, Fusanori; Iwaguro, Hideki; Harada, Yoko; Sobajima, Satoshi; Suwabe, Takako; Miyamoto, Shingo

doi:10.2217/rme-2020-0037

Cited by 16 publications

(20 citation statements)

References 60 publications

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“…In the AS and EA, the thickness of Endometrium increased approximately from 4.3 mm to 6.7 mm [ 48 ] menSCs Jichun Tan et al Human The transplantation of Autologous menSCs considerably rise endometrial thickness (ET) for women with severe AS [ 49 ] hESP cells Irene Cervelló et al Human The mesenchymal origin of hESP confirmed by their ability to differentiate in vitro into osteocytes and adipocytes. Eventually, after transplanted under renal capsule of NOD-SCID mice they have displayed the potency to generate human endometrium [ 50 ] Autologous adipose derived stem cells (ADSCs) Sudoma et al Human ADSCs subendometrial introduction led to endometrial thickness increase, 13 pregnancies occurred and 9 healthy babies were born [ 51 ] uterus derived mesenchymal stem cells and their exosomes Saribas et al Rat It was shown that proliferation and vascularization increased and fibrosis decreased in uterus as a result of MSC and exosome treatments [ 52 ] Autologous bone marrow-derived stem cell Singh et al Human Intrauterine stem cell treatment is a promising novel approach for refractory cases of AS and EA [ 53 ] Autologous adipose derived stem cells (ADSCs) Yotsumoto et al Mice ADSCs may be a useful therapeutic strategy to improve fertility of women with thin endometrium [ 54 ] Human amniotic epithelial cells (hAEC) Human amniotic epithelial cells (hAEC) Song et al Rat This study revealed that hESCs along with collagen scaffolds could notably support function recovery and uterine repair in a rat model of intense uterine injury [ 55 ...…”

Section: Platelet-rich Plasma (Prp)mentioning

confidence: 99%

Cell-based therapy in thin endometrium and Asherman syndrome

et al. 2022

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Numerous treatment strategies have so far been proposed for treating refractory thin endometrium either without or with the Asherman syndrome. Inconsistency in the improvement of endometrial thickness is a common limitation of such therapies including tamoxifen citrate as an ovulation induction agent, acupuncture, long-term pentoxifylline and tocopherol or tocopherol only, low-dose human chorionic gonadotropin during endometrial preparation, aspirin, luteal gonadotropin-releasing hormone agonist supplementation, and extended estrogen therapy. Recently, cell therapy has been proposed as an ideal alternative for endometrium regeneration, including the employment of stem cells, platelet-rich plasma, and growth factors as therapeutic agents. The mechanisms of action of cell therapy include the cytokine induction, growth factor production, natural killer cell activity reduction, Th17 and Th1 decrease, and Treg cell and Th2 increase. Since cell therapy is personalized, dynamic, interactive, and specific and could be an effective strategy. Despite its promising nature, further research is required for improving the procedure and the safety of this strategy. These methods and their results are discussed in this article.

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Section: Platelet-rich Plasma (Prp)mentioning

confidence: 99%

Cell-based therapy in thin endometrium and Asherman syndrome

et al. 2022

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“…We isolated ADRCs from the subcutaneous adipose tissues of BALB/c female mice and the KuO-expressing transgenic C57BL/6 mouse, as described previously 50 . ADRCs are almost identical to the stromal vascular fraction.…”

Section: Methodsmentioning

confidence: 99%

Trophic and immunomodulatory effects of adipose tissue derived stem cells in a preclinical murine model of endometriosis

Hirakawa

Yotsumoto

Shirasu

et al. 2022

Sci Rep

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Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through their trophic and immunomodulatory properties. To investigate the potential of stem cells in treating endometriosis, we examined the secondary morphology and molecular alterations in endometriosis-like lesions after the administration of adipose tissue-derived stem cells (ASCs) to an experimental murine model of endometriosis. The infused ASCs were found integrated in the endometriosis-like lesions. Accompanied by the suppression of stromal fibrosis and proliferation of endometriotic epithelial cells, the infusion of ASCs with stemness potential (early passage of ASCs) suppressed the growth of endometriosis-like lesions and inhibited the expression of pro-inflammatory and pro-fibrotic cytokines, whereas no significant attenuation of endometriosis-like lesions occurred after the infusion of ASCs without stemness potential (late passage of ASCs). Accordingly, the trophic and immunomodulatory properties of ASCs may regulate fibrosis in endometriosis-like lesions, suggesting that regenerative medicine could be recognized as an innovative treatment for patients with endometriosis through the accumulation of evidence of preclinical efficacy.

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“…FMC003; R&D Systems). Flow cytometry was performed as described previously [35]. For histological staining, the collected tissues were formalin-xed and then para n-embedded.…”

Section: Flow Cytometric Pathological and Immunohistochemical Analysesmentioning

confidence: 99%

“…We isolated ADRCs from the subcutaneous adipose tissues of BALB/c female mice and the KuOexpressing transgenic C57BL/6 mouse, as described previously [35]. ADRCs are almost identical to the stromal vascular fraction.…”

Section: Isolation Of Adipose-derived Regenerative Cells (Adrcs) and Ascsmentioning

confidence: 99%

Trophic And Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells In A Preclinical Murine Model of Endometriosis

Hirakawa¹,

Yotsumoto²,

Shirasu³

et al. 2021

Preprint

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Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through their trophic and immunomodulatory properties. To investigate the potential of stem cells in treating endometriosis, we examined the secondary morphology and molecular alterations in endometriosis-like lesions after the administration of adipose tissue-derived stem cells (ASCs) to an experimental murine model of endometriosis. The infused ASCs were found integrated in the endometriosis-like lesions. Accompanied by the suppression of stromal fibrosis and proliferation of endometriotic epithelial cells, the infusion of ASCs with stemness potential suppressed the growth of endometriosis-like lesions and inhibited the expression of pro-inflammatory and pro-fibrotic cytokines, whereas no significant attenuation of endometriosis-like lesions occurred after the infusion of ASCs without stemness potential. Accordingly, it is plausible that the trophic and immunomodulatory properties of ASCs may regulate fibrosis in endometriosis-like lesions, suggesting that regenerative medicine has strong potential as an innovative treatment for patients with endometriosis.

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Adipose Tissue-Derived Regenerative Cells Improve Implantation of Fertilized Eggs in Thin Endometrium

Cited by 16 publications

References 60 publications

Cell-based therapy in thin endometrium and Asherman syndrome

Cell-based therapy in thin endometrium and Asherman syndrome

Trophic and immunomodulatory effects of adipose tissue derived stem cells in a preclinical murine model of endometriosis

Trophic And Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells In A Preclinical Murine Model of Endometriosis

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