Adipose tissue IL‐8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women

Alvehus, Malin; Simonyte, Kotryna; Andersson, Therése; Söderström, Ingegerd; Burén, Jonas; Rask, Eva; Mattsson, Cecilia; Olsson, Tommy

doi:10.1111/j.1365-2265.2011.04322.x

Cited by 21 publications

(15 citation statements)

References 35 publications

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“…Correlative studies show that resistance exercise increases skeletal muscle mRNA expression of IL6 and IL8 [38]. Furthermore, in adipocytes, RYGB surgery has been reported to markedly reduce IL8 expression [39]. Therefore, local IL8 secretion could be more sensitive and an early marker of metabolic changes occurring 6 months after RYGB surgery.…”

Section: Discussionmentioning

confidence: 96%

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery

Nascimento

Riedl

Jiang

et al. 2015

Surgery for Obesity and Related Diseases

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Section: Discussionmentioning

confidence: 96%

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery

Nascimento

Riedl

Jiang

et al. 2015

Surgery for Obesity and Related Diseases

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“…Although IL-8 is one of the key chemokines that regulate migration and infiltration of neutrophils, expression of IL-8 is upregulated in the AT of obese patients (Alvehus et al. 2012). Interestingly, Neels et al.…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophils are recruited to various tissues through chemokines and adhesion molecules. Although IL-8 is one of the key chemokines that regulate migration and infiltration of neutrophils, expression of IL-8 is upregulated in the AT of obese patients (Alvehus et al 2012). Interestingly, Neels et al (2009) showed that in obese mice deficient in CXCL2, the receptor for IL-8, presented reduced macrophage infiltration in the AT from levels in control obese mice (Neels et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Exercise training attenuates neutrophil infiltration and elastase expression in adipose tissue of high-fat-diet-induced obese mice

et al. 2015

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The innate immune system is associated with the development of local inflammation. Neutrophils play an essential role in the development of the adipose tissue (AT) inflammation associated with obesity by producing elastase, which can promote the activation and infiltration of macrophages. Exercise training attenuates AT inflammation via suppression of macrophage infiltration. However, the mechanisms driving this phenomenon remains to be elucidated. Here, we evaluated the effects of exercise training on the infiltration of neutrophils and elastase expression in an obese mouse model. Four-week-old male C57BL/6J mice were randomly assigned to one of three groups that either received a normal diet (ND) plus sedentary activity (n = 15), a high-fat diet (HFD) plus sedentary activity (n = 15), or a HFD plus exercise training (n = 15). Mice were fed the ND or HFD from the age of 4 weeks until 20 weeks. Mice in the exercise group ran on a treadmill for 60 min/day, 5 days/week over the same experimental period. Mice fed with the HFD had increased content of macrophages in the AT and increased inflammatory cytokine mRNA levels, which were reduced by exercise training. Similarly, AT from the HFD sedentary mice contained more neutrophils than AT from the ND mice, and the amount of neutrophils in this tissue in HFD-fed mice was lowered by exercise training. The mRNA levels of neutrophil elastase in AT were lower in the HFD exercise-trained mice than those in the HFD sedentary mice. These results suggest that exercise training plays a critical role in reducing macrophage infiltration and AT inflammation by regulating the infiltration of neutrophils.

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“…The menopause was characterized by increased body weight (Alvehus et al 2012). First, we investigated the regulatory effect of body weight of PPE or Arg in the OVX mice.…”

Section: Administration With Ppe or Arg Improved Body And Vagina Weigmentioning

confidence: 99%

Protective effect of porcine placenta in a menopausal ovariectomized mouse

et al. 2015

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Menopause is a significant physiological phase that occurs as women's ovaries stop producing ovum and the production of estrogen declines. Human placenta and some amino acids are known to improve menopausal symptoms. In this study, we investigated that porcine placenta extract (PPE) and arginine (Arg), a main amino acid of PPE, would have estrogenic activities in ovariectomized (OVX) mice as a menopause mouse model, human breast cancer cell line (MCF-7) cells, and human osteoblast cell line (MG-63) cells. PPE or Arg significantly inhibited the body weight and increased the vagina weight compared to the OVX mice. PPE or Arg ameliorated the vaginal atrophy in the OVX mice. The levels of 17b-estradiol and the activities of alkaline phosphatase (ALP) were significantly increased by PPE or Arg in the serum of OVX mice. Trabecular bone parameters such as bone mineral density and porosity were also improved by PPE or Arg in the OVX mice. In the MCF-7 and MG-63 cells, PPE or Arg significantly increased the cell proliferation, estrogen receptor b mRNA expression, and estrogen-response elements luciferase activity. Finally, PPE or Arg increased the activations of ALP and extracellular signalregulated kinase 1/2 in the MG-63 cells. These results indicate that PPE or Arg would have estrogenic and osteoblastic activity. Therefore, PPE or Arg may be useful as new pharmacological tools for treating menopausal symptoms including osteoporosis. Free Korean abstract: A Korean translation of this abstract is freely available at

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Adipose tissue IL‐8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women

Cited by 21 publications

References 35 publications

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery

Exercise training attenuates neutrophil infiltration and elastase expression in adipose tissue of high-fat-diet-induced obese mice

Protective effect of porcine placenta in a menopausal ovariectomized mouse

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