Adipose tissue plasticity from WAT to BAT and in between

Lee, Yun Hee; Mottillo, Emilio P.; Granneman, James G.

doi:10.1016/j.bbadis.2013.05.011

Cited by 183 publications

(183 citation statements)

References 262 publications

(323 reference statements)

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“…In fact, several (138) although not all (139) observational studies have suggested an association between high birth-weight and T2D risk in adulthood, highlighting that the possible protection associated with accelerated early growth may be somewhat transient. Even within the context of higher adipogenic and lipogenic potential in SAT, buffering capacity can be exceeded by chronic overnutrition, resulting in MUO development (140) .…”

Section: Gestationmentioning

confidence: 99%

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

et al. 2014

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Evidence suggests that at a population level, childhood and adolescent obesity increase the long-term risk of chronic diseases such as type 2 diabetes and CVD. At an individual level, however, the metabolic consequences of obesity in youth vary immensely. Despite comparable BMI, some adolescents develop impaired glucose tolerance while others maintain normal glucose homeostasis. It has been proposed that the variation in the capacity to store lipid in the subcutaneous adipose tissue (SAT) may partially discriminate metabolically healthy from unhealthy obesity. In positive energy balance, a decreased capacity to expand SAT may drive lipid accumulation to visceral adipose tissue, liver and skeletal muscle. This state of lipotoxicity is associated with chronic low-grade inflammation, insulin resistance and dyslipidaemia. The present review examines the differential adipose tissue development and function in children and adolescents who exhibit metabolic dysregulation compared with those who are protected. Additionally, the role of manipulating dietary fat quality to potentially prevent and treat metabolic dysfunction in obesity will be discussed. The findings of the present review highlight the need for further randomised controlled trials to establish the effect of dietary n-3 PUFA on the metabolic phenotype of obese children and adolescents. Furthermore, using a personalised nutrition approach to target interventions to those at risk of, or those with established metabolic dysregulation may optimise the efficacy of modifying dietary fat quality.

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Section: Gestationmentioning

confidence: 99%

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

et al. 2014

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“…In vivo, brite adipocytes stem from progenitors or emerge by direct conversion of mature white adipocytes (22)(23)(24). Several studies have demonstrated the involvement of oxylipins in fat mass development through the modulation of white and brown/brite adipocyte differentiation and activity (25).…”

Section: Introductionmentioning

confidence: 99%

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Ghandour

Colson

Giroud

et al. 2018

Journal of Lipid Research

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“…Adipose tissue has notable plasticity throughout life (9) and is a highly active endocrine organ (10). It contains adipocytes, connective tissue matrices, nerve tissue, stromovascular cells, and immune cells (11).…”

Section: Introductionmentioning

confidence: 99%

“…They have the ability to differentiate into numerous cell lineages, including adipogenic, osteogenic, chondrogenic, myogenic, cardiomyogenic, and neurogenic-like cell types (9,(21)(22)(23)(24)(25). They have been associated with expressing/secreting multiple important growth factors, cytokines, chemokines, and inflammatory biomarkers linked to cancer development and progression, including insulin-like growth factor (IGF), hepatocyte growth factor (HGF), TGFb1, VEGF, IL8, Bcl-2, and IL10 (26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Stems Cells and Their Role in Human Cancer Development, Growth, Progression, and Metastasis: A Systematic Review

et al. 2015

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Obesity is a well recognized risk factor for several types of cancers, many of which occur solely or disproportionately in women. Adipose tissue is a rich source of adipose-derived stem cells (ASC), which have received attention for their role in cancer behavior. The purpose of this systematic review is to present the existing literature on the role of ASCs in the growth, development, progression, and metastasis of cancer, with an emphasis on malignancies that primarily affect women. To accomplish this goal, the bibliographic database PubMed was systematically searched for articles published between 2001 and 2014 that address ASCs' relationship to human cancer. Thirty-seven articles on ASCs' role in human cancer were reviewed. Literature suggests that ASCs exhibit cancer-promoting properties, influence/are influenced by the tumor microenvironment, promote angiogenesis, and may be associated with pathogenic processes through a variety of mechanisms, such as playing a role in hypoxic tumor microenvironment. ASCs appear to be important contributors to tumor behavior, but research in areas specific to women's cancers, specifically endometrial cancer, is scarce. Also, because obesity continues to be a major health concern, it is important to continue research in this area to improve understanding of the impact adiposity has on cancer incidence. Cancer Res; 75(7); 1161-8. Ó2015 AACR.

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Adipose tissue plasticity from WAT to BAT and in between

Cited by 183 publications

References 262 publications

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Adipose-Derived Stems Cells and Their Role in Human Cancer Development, Growth, Progression, and Metastasis: A Systematic Review

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