Adiposity associated rise in leptin impairs ovarian activity during winter dormancy in Vespertilionid bat, Scotophilus heathi

Srivastava, Rai Ajit K.; Krishna, Amitabh

doi:10.1530/rep.1.01019

Cited by 36 publications

(41 citation statements)

References 72 publications

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“…Although glycogen has an important role in energy homeostasis, several bat species rely mainly on lipid reserves to support reproductive activities (Kunz et al, 1998;Krishna et al, 1998;Srivastava and Krishna, 2007;2008). The data obtained here seem to indicate that lipid reserves of male M. molossus remained unaltered in all seasons, except for the adiposity index.…”

Section: Discussionmentioning

confidence: 51%

“…It has been reported that insect-eating bats are able of fly while foraging powered by exogenous (dietary nutrients) rather than endogenous sources (glycogen or lipids) (Voigt et al, 2010). Reproductive activity in insect-eating bats also seems to require great energy expenditure, but this is based mainly on body lipid reserves stored during the previous seasons (Kunz et al, 1998;Krishna et al, 1998;Srivastava and Krishna, 2007;2008).…”

Section: Discussionmentioning

confidence: 99%

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Seasonal variation of energy reserves and reproduction in neotropical free-tailed bats Molossus molossus (Chiroptera: Molossidae)

et al. 2013

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Seasonal variation is a key factor regulating energy metabolism and reproduction in several mammals, including bats. This study aimed to track seasonal changes in the energy reserves of the insectivorous bat Molossus molossus associated with its reproductive cycle. Adult males were collected during the four neotropical annual seasons in Viçosa -MG, Brazil. Blood and tissues were collected for metabolic analysis and testes were removed for histology and morphometry. Our results show that liver and breast muscle glycogen concentrations were significantly lower in winter. The adiposity index was significantly higher in the fall compared to winter and spring. Seminiferous tubules were greater in diameter in animals captured in fall and winter, indicating a higher investment in spermatic production during these seasons. The percentage of Leydig cells was higher in summer compared to fall and winter. We suggest that M. molossus presents a type of seasonal reproduction with two peaks of testicular activity: one in fall, with higher sperm production (spermatogenesis), and another in summer, with higher hormone production (steroidogenesis). The metabolic pattern may be associated with reproductive events, especially due to the highest fat storage observed in the fall, which coincides with the further development of the seminiferous tubules.Keywords: spermatogenesis, histology, insectivorous, males, metabolism. Variação sazonal das reservas energéticas e a reprodução do morcego neotropical de cauda livre Molossus molossus (Chiroptera: Molossidae) ResumoA variação sazonal é um fator chave na regulação do metabolismo energético e da reprodução em vários mamíferos, incluindo os morcegos. O objetivo deste estudo foi avaliar as reservas energéticas do morcego insetívoro Molossus molossus ao longo das estações anuais associadas ao seu ciclo reprodutivo. Foram coletados machos adultos durante as quatro estações anuais na cidade de Viçosa -MG, Brasil. Para as análises metabólicas foram coletados tecidos e sangue, e os testículos foram removidos para análises histológicas e morfométricas. Os resultados mostram que as concentrações de glicogênio no fígado e músculo peitoral foram significativamente menores no inverno. O índice adiposo foi significativamente maior no outono em relação ao inverno e primavera. Os túbulos seminíferos apresentaram maiores diâmetros nos animais coletados no outono e inverno, indicando um maior investimento na produção espermática durante estas estações. A porcentagem de células de Leydig foi maior no verão em comparação com outono e inverno. Sugere-se que M. molossus apresenta um tipo de reprodução sazonal com dois picos de atividade testicular: uma no outono, com maior produção de espermatozóides (espermatogênese), e outra no verão, com maior produção de hormônio (esteroidogênese). O padrão metabólico pode estar associado a eventos reprodutivos, especialmente devido ao maior armazenamento de gordura observado no outono, que coincide com o desenvolvimento dos túbulos seminíferos.Palavras-chave: e...

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Seasonal variation of energy reserves and reproduction in neotropical free-tailed bats Molossus molossus (Chiroptera: Molossidae)

et al. 2013

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“…Their ovaries were quickly taken out and cleaned of any adhered fat tissue and oviduct in DMEM (Himedia, Mumbai, India) containing 250 U/ml penicillin and 250 mg/ml streptomycin sulfate. Ovaries were cultured by the method as described previously (Srivastava & Krishna 2007) with some modifications. Culture medium was a mixture of DMEM (with sodium pyruvate and L-glutamine) and Ham's F-12 (1:1; v/v) Himedia) containing 100 U/ml penicillin, 100 mg/ml streptomycin, and 0.1% BSA (Sigma).…”

Section: Effect Of Melatonin On Ovarian Steroidogenesismentioning

confidence: 99%

“…Furthermore, protein extractions and immunoblotting were performed as described previously (Srivastava & Krishna 2007). Equal amount of proteins (50 mg) as determined by Folin's method was loaded on to SDS-PAGE (10%) for electrophoresis.…”

Section: Immunoblotmentioning

confidence: 99%

Melatonin regulates delayed embryonic development in the short-nosed fruit bat, Cynopterus sphinx

Banerjee

Meenakumari²,

Udin³

et al. 2009

Reproduction

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The aim of the present study was to evaluate the seasonal variation in serum melatonin levels and their relationship to the changes in the serum progesterone level, ovarian steroidogenesis, and embryonic development during two successive pregnancies of Cynopterus sphinx. Circulating melatonin concentrations showed two peaks; one coincided with the period of low progesterone synthesis and delayed embryonic development, whereas the second peak coincided with regressing corpus luteum. This finding suggests that increased serum melatonin level during November-December may be responsible for delayed embryonic development by suppressing progesterone synthesis. The study showed increased melatonin receptors (MTNR1A and MTNR1B) in the corpus luteum and in the utero-embryonic unit during the period of delayed embryonic development. The in vitro study showed that a high dose of melatonin suppressed progesterone synthesis, whereas a lower dose of melatonin increased progesterone synthesis by the ovary. The effects of melatonin on ovarian steroidogenesis are mediated through changes in the expression of peripheral-type benzodiazepine receptor, P450 side chain cleavage enzyme, and LH receptor proteins. This study further showed a suppressive impact of melatonin on the progesterone receptor (PGR) in the utero-embryonic unit; this effect might contribute to delayed embryonic development in C. sphinx. The results of the present study thus suggest that a high circulating melatonin level has a dual contribution in retarding embryonic development in C. sphinx by impairing progesterone synthesis as well as by inhibiting progesterone action by reducing expression of PGR in the utero-embryonic unit. Reproduction (2009) 138 935-944

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“…For example, in the Scotophilus heathii bat has been reported that serum leptin levels are positively correlated with body fat and negatively related to reproductive function [16][17].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between the Amount of Subcutaneous Fat, Testicular Morphometry, Epididymis and Some Sperm Parameters in Leptonycteris yerbabuenae Bat Before, During and After Mating

Martínez–Coronel¹,

Alicia²,

Arenas‐Ríos³

2015

AVS

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Studies in reproductive age mammals show that the increase in fat content is inversely related to sperm quality in response to a decrease in testosterone levels. In turn the decrease in androgen concentration is related to morphophysiological involution in the testis and epididymis. However, the bat Leptonycteris yerbabuenae increases the body fat content previous the mating period, contrary to what was reported in most mammals. Therefore the aim of this study was to determine the importance of variation in fat content in L. yerbabuenae in relation to testicular and epididymal cycle; and sperm parameters. The results clearly show an increase in the fat content as it approaches the mating season. Also, there is an increase in the size of the testis and epididymis. In the post-mating months, both: fat and testis, decrease and the sperm cells were not presents. Leptonycteris yerbabuenae has a different behaviour to most mammals, accumulate fat while producing, transit and sperm storage could be happening. So, in this model, we must do studies that meet these processes emerging from that reported in other mammals.

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Adiposity associated rise in leptin impairs ovarian activity during winter dormancy in Vespertilionid bat, Scotophilus heathi

Cited by 36 publications

References 72 publications

Seasonal variation of energy reserves and reproduction in neotropical free-tailed bats Molossus molossus (Chiroptera: Molossidae)

Seasonal variation of energy reserves and reproduction in neotropical free-tailed bats Molossus molossus (Chiroptera: Molossidae)

Melatonin regulates delayed embryonic development in the short-nosed fruit bat, Cynopterus sphinx

Relationship Between the Amount of Subcutaneous Fat, Testicular Morphometry, Epididymis and Some Sperm Parameters in Leptonycteris yerbabuenae Bat Before, During and After Mating

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