Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial

Abu-Ta’a, Mahmoud

doi:10.5005/jp-journals-10024-1794

Cited by 16 publications

(26 citation statements)

References 8 publications

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“… d MIVs, minimally invasive variants, including minimally invasive surgical approach (Harrel 1999) and minimally invasive surgical technique (Cortellini et al 2007). e For the analysis, the 2 treatment arms of the study by Rollke et al (2012; i.e., EMD alone with or without systemic doxycycline at sites accessed with modified papilla preservation technique/simplified papilla preservation technique) were considered single arms from 2 different studies. f For the analysis, the 2 treatment arms of the study by Abu-Ta’a (2016; i.e., EMD + demineralized freeze-dried bone allograft) with or without systemic amoxicillin at sites accessed with modified papilla preservation technique) and Trombelli et al (2018; i.e., EMD + demineralized bovine bone mineral at sites accessed with a single-flap approach in smokers and nonsmokers) were considered as arms from 2 different studies. …”

Section: Resultsmentioning

confidence: 99%

“… f For the analysis, the 2 treatment arms of the study by Abu-Ta’a (2016; i.e., EMD + demineralized freeze-dried bone allograft) with or without systemic amoxicillin at sites accessed with modified papilla preservation technique) and Trombelli et al (2018; i.e., EMD + demineralized bovine bone mineral at sites accessed with a single-flap approach in smokers and nonsmokers) were considered as arms from 2 different studies. …”

Section: Resultsmentioning

confidence: 99%

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Effect of Flap Design for Enamel Matrix Derivative Application in Intraosseous Defects

Trombelli

Simonelli

Quaranta

et al. 2020

JDR Clinical & Translational Research

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Objective: To systematically review the literature addressing the focused question: What is the effectiveness of different surgical and nonsurgical procedures combined with enamel matrix derivative (EMD) on clinical, radiographic, and patient-centered outcomes in intraosseous defects? Methods: Electronic (Medline, Scopus, and Cochrane databases) and hand literature searches were performed for studies including at least 1 treatment arm where EMD had been applied according to 1 of the following procedures: modified Widman flap; papilla preservation variants (PPVs), including papilla preservation technique, modified papilla preservation technique, and simplified papilla preservation technique; minimally invasive variants, including minimally invasive surgical approach and minimally invasive surgical technique; single-flap variants (SFVs), including single-flap approach and modified minimally invasive surgical technique; or nonsurgical application (flapless approach). Data from 42 selected articles were used to perform a network meta-analysis, and a hierarchy of surgical and nonsurgical applications of EMD was built separately for EMD and EMD + graft based on 6- to 12-mo clinical and radiographic outcomes. Results: Among surgical approaches, EMD was associated with best regenerative outcomes when applied through SFVs, with a mean clinical attachment level gain of 3.93 mm and a reduction in the intrabony component of the defect of 3.35 mm. For EMD + graft, limited differences in regenerative outcomes were observed among surgical procedures. PPVs were associated with the highest residual probing depth for EMD (4.08 mm) and EMD + graft (4.32 mm). Conclusions: In the treatment of periodontal intraosseous defects, 1) SFVs appear to optimize the regenerative outcomes of EMD; 2) substantial regenerative outcomes can be obtained with SFVs and conservative double flaps (i.e., PPVs and minimally invasive variants) when EMD is combined with a graft; and 3) residual probing depth was higher following PPVs for EMD and EMD + graft. Knowledge Transfer Statement: The results of the present systematic review and meta-analysis can be used by clinicians to identify the most effective surgical or nonsurgical procedure to treat an intraosseous defect with EMD or EMD + graft. The main findings indicate that when EMD application is indicated, surgical access based on a single flap seems the most appropriate to optimize clinical outcomes. The application of EMD + graft can be effectively combined with single flaps and conservative double flaps.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effect of Flap Design for Enamel Matrix Derivative Application in Intraosseous Defects

Trombelli

Simonelli

Quaranta

et al. 2020

JDR Clinical & Translational Research

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“…poor glycemic control diabetes, hepatic cirrhosis, renal insufficiency, malnutrition). 2 Cephalosporins should not be used in patients with a history of anaphylaxis, angio-edema, or urticaria after intake of penicillins.…”

Section: General Recommendations For Antibiotic Prophylaxis Against Smentioning

confidence: 99%

Polish Dental Association And National Programme To Protect Antibiotics Working Group recommendations for administration of antibiotics in dentistry

Kaczmarzyk¹,

Babiuch²,

Bołtacz-Rzepkowska³

et al. 2018

jos

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“…The focus of the present study is to investigate the potential of antibiotic‐loaded FGMs in facilitating the repair of experimental periodontitis. Amoxicillin (AMX) was selected according to its broad‐spectrum antibacterial activity, which has been effectively demonstrated in the treatment of head and neck infection, and has been indicated as an adjunctive for treating periodontitis and maintaining periodontal wounds 18–20 . As reported by Cheng et al., 10,11 the adhesions of Streptococcus mutans and Aggregatibacter actinomycetemcomitans were greatly reduced on AMX‐absorbed membranes.…”

Section: Introductionmentioning

confidence: 99%

The treatment response of barrier membrane with amoxicillin‐loaded nanofibers in experimental periodontitis

Claudia

Tai

et al. 2020

Journal of Periodontology

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Background Infection control is a major determinant of guided tissue regeneration (GTR). This study aims to develop an antibiotic‐loaded membrane to assist periodontal repair. Methods Poly(D,L‐lactic acid) (PDLLA) nanofibers encapsulating amoxicillin (PDLLA‐AMX) were fabricated using the electrospinning technique, and their structures, drug encapsulation efficiency, and release characteristics were assessed. The viability and behaviors of periodontal ligament (PDL) cells on nanofibers, and antibacterial capabilities of nanofibers were evaluated in vitro. Early therapeutic efficiency of the antibiotic‐loaded membranes was investigated in rats with ligature‐induced experimental periodontitis, and the outcomes were evaluated by gene expression, microcomputed tomography imaging, and histology within 7 days of membrane placement. Results AMX was successfully encapsulated in the PDLLA nanofibers and released in a sustained manner. After initial attachment was achieved, cells stretched out along with the directions of nanofibers. The viability and expression of migration‐associated gene of PDL cells were significantly improved, and the growth of Streptococcus sanguinis and Porphyromonas gingivalis was significantly reduced in the PDLLA‐AMX group compared with the controls. On PDLLA‐AMX‐treated sites, wound dehiscence and sulcular inflammation were reduced. Collagen fiber matrix deposition was accelerated with upregulated type I collagen and interleukin‐1β, and downregulated matrix metalloproteinase‐8, whereas periodontal bone level and the expressions of vascular endothelial growth factor and core‐binding factor subunit alpha‐1 were equivalent to conventional membrane treatment. Conclusions PDLLA‐AMX nanofibers inhibited bacterial growth and promoted the viability and mobility of PDL cells after initial cell attachment. Membranes with PDLLA‐AMX nanofibers reduced inflammation and accelerated periodontal repair at an early stage, providing good prospects for the further development of GTR membranes.

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Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial

Abstract: Regarding the results of this study, adjunc-tive systemic antibiotics in combination with guided tissue regeneration may be useful in reducing postoperative discomfort but may not be helpful for improving periodontal regeneration outcomes.

Cited by 16 publications

References 8 publications

Effect of Flap Design for Enamel Matrix Derivative Application in Intraosseous Defects

Effect of Flap Design for Enamel Matrix Derivative Application in Intraosseous Defects

Polish Dental Association And National Programme To Protect Antibiotics Working Group recommendations for administration of antibiotics in dentistry

The treatment response of barrier membrane with amoxicillin‐loaded nanofibers in experimental periodontitis

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