Adjunctive Treatment With Risperidone in Clozapine-Resistant Schizophrenia

Abstract

Despite the contradictory nature of the published data, our results are in support of other work reporting that treatment with a combination of clozapine and risperidone, apart from being well tolerated, may constitute an effective alternative in this type of patient. Nevertheless, there is a need for further, controlled studies, with larger samples, with a view to drawing definitive conclusions and making specific recommendations.

<p>Clozapine Use in Patients with Early-Stage Schizophrenia in a Chinese Psychiatric Hospital</p>

“…Consequently, a case report and review demonstrated that the combination of clozapine and risperidone was well tolerated and effective in treating patients with clozapine-resistant schizophrenia. 46 Psychiatrists may have added clozapine to treat a portion of patients who did not respond well to risperidone in the present study.…”

Evolution of the Concept of Treatment-resistant Schizophrenia: Toward a Reformulation for Lack of an Adequate Response

“…It involves deterioration in social adjustment, reduction in the capacity to access rehabilitation programs, and high healthcare costs. 36 Even with overall treatment today, many patients experience variable and fluctuating remission of positive and negative symptoms. In spite of a reduced number of chronic inpatients, this hampers adaptation to the demands of daily life: studies, work, family, partner, social relations, etc.…”

Long-acting injectable risperidone and metabolic ratio: a possible index of clinical outcome in treatment-resistant schizophrenic patients

“…However, a considerable number of patients are unresponsive to clozapine or only partially respond (Mauri et al 2003): long-term studies show that 47-63% of schizophrenic patients treated with clozapine fail to respond after 12 years of treatment (Lerma-Carrillo et al 2007). …”