Adjuvant Chemotherapy and Radiation Therapy is Associated with Improved Survival for Patients with Extrahepatic Cholangiocarcinoma

Abstract

This national analysis suggests that ACR are associated with improved survival for high-risk EHC patients, such as those with positive lymph nodes. Until randomized clinical trials are conducted, these may be the best available data to guide adjuvant therapy for resected EHC.

Impact of adjuvant chemoradiation on survival in patients with resectable cholangiocarcinoma

“…These results corroborate another recent retrospective experience reported from Shanghai of resected intrahepatic CC and concurrent lymph node involvement showing an almost 10-month OS benefit with adjuvant RT (n = 24) as compared to surgery alone (n = 66). 26 Our results are further in line with two large database studies: Abott et al recently analyzed a national cancer database (n = 8741) demonstrating a benefit in OS with adjuvant CRT after surgical resection of extrahepatic CC regardless of margin status, 27 and a retrospective SEER analysis of patients with intrahepatic CC (n = 3839) showed an OS benefit of five months with adjuvant RT (n = 269) as compared to surgery alone (n = 960). 15 As opposed these large national database inquiries which lack not only specifics of therapy but also in-depth demographic and tumor detail, our results provide an inclusive analysis of a number of clinicopathologic factors potentially at play.…”

ZEB1 expression is associated with prognosis of intrahepatic cholangiocarcinoma

“…First, only patients with a medical record sufficient for evaluation were enrolled. Additionally, postoperative adjuvant chemotherapy was received by only 19 patients but was not assigned with a comprehensive organised strategy; therefore, the influence of adjuvant chemotherapy29 30 on clinical outcome is not clear.…”

Surgical management of hilar cholangiocarcinoma at Memorial Sloan Kettering Cancer Center

“…Given these randomized data, capecitabine in the adjuvant setting has become the standard of care for all patients. Additionally, for patients with residual disease (positive margins) or for those at high risk of recurrence (positive nodes), adjuvant radiation therapy may also be considered, although there are no randomized data to support this strategy …”