Adjuvant eflornithine to maintain <scp>IPL</scp>‐induced hair reduction in women with facial hirsutism: a randomized controlled trial

Vissing, A C; Taudorf, E.; Haak, Christina Skovbølling; Philipsen, Peter Alshede; Hædersdal, Merete

doi:10.1111/jdv.13447

Cited by 19 publications

(9 citation statements)

References 24 publications

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“…4C). ODC inhibitor DFMO is a Food and Drug Administration-approved medicine for hirsutism and African sleeping sickness and has been widely tested as a chemopreventive and chemotherapeutic agent against solid tumors (30,31). Similar to the genetic data, DFMO alone failed to suppress EAE pathogenic progression ( Fig.…”

Section: Simultaneously Blocking Polyamine Salvage and Biosynthesis Smentioning

confidence: 77%

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

Chen

Kang

et al. 2020

Sci. Adv.

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Robust and effective T cell–mediated immune responses require proper allocation of metabolic resources through metabolic pathways to sustain the energetically costly immune response. As an essential class of polycationic metabolites ubiquitously present in all living organisms, the polyamine pool is tightly regulated by biosynthesis and salvage pathway. We demonstrated that arginine is a major carbon donor and glutamine is a minor carbon donor for polyamine biosynthesis in T cells. Accordingly, the dependence of T cells can be partially relieved by replenishing the polyamine pool. In response to the blockage of biosynthesis, T cells can rapidly restore the polyamine pool through a compensatory increase in extracellular polyamine uptake, indicating a layer of metabolic plasticity. Simultaneously blocking synthesis and uptake depletes the intracellular polyamine pool, inhibits T cell proliferation, and suppresses T cell inflammation, indicating the potential therapeutic value of targeting the polyamine pool for managing inflammatory and autoimmune diseases.

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Section: Simultaneously Blocking Polyamine Salvage and Biosynthesis Smentioning

confidence: 77%

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

Chen

Kang

et al. 2020

Sci. Adv.

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“…High doses are used as part of a highly successful therapy for sleeping sickness caused by Trypanosome brucei subsp . gambiense 87 , and it is clinically approved for treatment of hirsutism 88 .…”

Section: Targeting Of Polyamine Metabolismmentioning

confidence: 99%

Polyamine metabolism and cancer: treatments, challenges and opportunities

2018

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Advances in our understanding of the metabolism and molecular functions of polyamines and their alterations in cancer have led to resurgence in the interest of targeting polyamine metabolism as an anticancer strategy. Increasing knowledge of the interplay between polyamine metabolism and other cancer-driving pathways, including the PTEN-PI3K-mTOR complex 1 (mTORC1), WNT signalling and RAS pathways, suggests potential combination therapies that will have considerable clinical promise. Additionally, an expanding number of promising clinical trials with agents targeting polyamines for both therapy and prevention are ongoing. New insights into molecular mechanisms linking dysregulated polyamine catabolism and carcinogenesis suggest additional strategies that can be used for cancer prevention in at-risk individuals. In addition, polyamine blocking therapy, a strategy that combines the inhibition of polyamine biosynthesis with the simultaneous blockade of polyamine transport, can be more effective than therapies based on polyamine depletion alone and may involve an antitumour immune response. These findings open up new avenues of research into exploiting aberrant polyamine metabolism for anticancer therapy.

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“…Drawbacks included non-response in 30% of users and regrowth to pretreatment levels within 8 weeks of discontinuation. Three other RCTs performed in hirsute women showed the ability of topical eflornithine when added to photoepilation to promote faster and more complete laser removal of facial hirsutism and to reduce hair regrowth between laser sessions and after cessation of IPL use [216, 217]. Laser epilation is most effective when used to treat areas of full, dark hair on light-skinned people.…”

Section: Treatment Of Pcosmentioning

confidence: 99%

An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence

Ibáñez¹,

et al. 2017

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This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)¹. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels. Appropriate diagnosis of adolescent PCOS should include adequate and careful evaluation of symptoms, such as hirsutism, severe acne, and menstrual irregularities 2 years beyond menarche, and elevated androgen levels. Polycystic ovarian morphology on ultrasound without hyperandrogenism or menstrual irregularities should not be used to diagnose adolescent PCOS. Hyperinsulinemia, insulin resistance, and obesity may be present in adolescents with PCOS, but are not considered to be diagnostic criteria. Treatment of adolescent PCOS should include lifestyle intervention, local therapies, and medications. Insulin sensitizers like metformin and oral contraceptive pills provide short-term benefits on PCOS symptoms. There are limited data on anti-androgens and combined therapies showing additive/synergistic actions for adolescents. Reproductive aspects and transition should be taken into account when managing adolescents.

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Adjuvant eflornithine to maintain IPL‐induced hair reduction in women with facial hirsutism: a randomized controlled trial

Abstract: Topical eflornithine provides a self-administered treatment with a potential to maintain IPL-induced hair reduction in hirsute patients.

Cited by 19 publications

References 24 publications

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

Polyamine metabolism and cancer: treatments, challenges and opportunities

An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence

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