Adjuvant Hyperbaric Oxygen Therapy in the Treatment of Hemodialysis Patients with Chronic Osteomyelitis

Chen, Chen-Yin; Lin, Kou-Ping; Lu, Shan-Hong; Chen, Yu-Ji; Lin, Cheng Feng

doi:10.1080/08860220701813384

Cited by 12 publications

(11 citation statements)

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“…Other proposed mechanisms for its efficacy are inducing angiogenesis, suppressing anaerobic organisms, enhancing antibiotic activity, and promoting oxygendependent osteoclastic resorption of necrotic bone. 73,74 Chen et al 75 and Chen et al 76 have reported on successful treatment of chronic osteomyelitis using hyperbaric oxygen therapy. Skeik et al retrospectively reviewed 118 patients where hyperbaric oxygen was used for different indications.…”

Section: Various Adjunctive Therapies Have Been Used In Patientsmentioning

confidence: 99%

Optimal management of chronic osteomyelitis: current perspectives

Pande¹

2015

ORR

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Chronic osteomyelitis is a challenging condition to treat. It is seen mostly after open fractures or in implant-related infections following treatment of fractures and prosthetic joint replacements. Recurrence of infection is well known, and successful treatment requires a multidisciplinary team approach with surgical debridement and appropriate antimicrobial therapy as the cornerstone of treatment. Staging of the disease and identification of the causative microorganism is essential before initiation of treatment. Important surgical steps include radical debridement of necrotic and devitalized tissue, removal of implants, management of resultant dead space, soft-tissue coverage, and skeletal stabilization or management of skeletal defects. The route of administration and duration of antimicrobial therapy continues to be debated. The role of biofilm is now clearly established in the chronicity of bone infection, and newer modalities are being developed to address various issues related to biofilm formation. The present review addresses various aspects of chronic osteomyelitis of long bones seen in adults, with a review of recent developments.

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Section: Various Adjunctive Therapies Have Been Used In Patientsmentioning

confidence: 99%

Optimal management of chronic osteomyelitis: current perspectives

Pande¹

2015

ORR

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“…HBOT works by favoring the action of the inflammatory cells and increases the host response to the targeted pain and swelling. A study conducted in 2008 proved that HBOT has an 80% success rate with a 21-day treatment 39. It can be concluded that HBOT is powerful in conjunction to aggressive medical and surgical treatment 40…”

Section: Uses In Dentistrymentioning

confidence: 99%

Clinical utility of hyperbaric oxygen therapy in dentistry

Patel

Gandhi

et al. 2019

Med Gas Res

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This fuller impact of the use of hyperbaric oxygen therapy within dentistry is taking greater notice with newer research findings. There are new advancements in research regarding postradiotherapy cases, osteonecrosis of the jaw, osteomyelitis, periodontal disease, and dental implants. Hyperbaric oxygen therapy can even be used in conjunction with other procedures such as bone grafting. Although the research and clinical utility has come a long way, there are several complications to be mindful of during the application of hyperbaric oxygen therapy.

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“…In clinical nephrology, HBOT was used in cutaneous ulcers due to calciphylaxis, chronic osteomyelitis, hemorrhagic cystitis, and renal zygomycosis [36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy in a patient with autosomal dominant polycystic kidney disease with a perinephritic abscess

et al. 2010

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A 68-year-old female in hemodialysis due to autosomal dominant polycystic kidney disease underwent resection of cysts in her right kidney via a laparoscopic approach due to abdominal pain. Three weeks after surgery, she was admitted with sepsis. A CT scan showed a large abscess around the right kidney. Percutaneous drainage of abscess was performed. The pus smear showed Gram-positive cocci and the culture contained methicillin-resistant Staphylococcus aureus. Ciprofloxacin, clindamycin and vancomycin were given. In the 3 weeks following admission, she remained febrile and septic and showed a progressive deterioration in her general condition, along with malnutrition and persistent drainage of purulent material from her right flank. The antibiotic therapy was changed to vancomycin, metronidazole and meropenem, but no improvement was observed. Because of the high risk associated with carrying out an open nephrectomy, we decided to use hyperbaric oxygen therapy (HBOT) as a potentially useful measure to control her infection. The patient underwent 26 daily sessions of 100% hyperbaric oxygen (2.5 atm). The use of HBOT induced a notable break in the clinical course of this patient's retroperitoneal infection. She was discharged after day 58 without any signs of inflammatory activity, and she has not presented reactivation of infection since then. We think that this case suggests that this therapy could be a new therapeutic tool in the management of patients with similar clinical features when all other therapeutic measures have failed. We did not find any other reports of the use of HBOT in infections of renal cysts.

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Adjuvant Hyperbaric Oxygen Therapy in the Treatment of Hemodialysis Patients with Chronic Osteomyelitis

Abstract: Hyperbaric oxygen is effective as an adjunct to aggressive medical and surgical treatment in chronic refractory osteomyelitis among hemodialysis-dependent patients.

Cited by 12 publications

References 0 publications

Optimal management of chronic osteomyelitis: current perspectives

Optimal management of chronic osteomyelitis: current perspectives

Clinical utility of hyperbaric oxygen therapy in dentistry

Hyperbaric oxygen therapy in a patient with autosomal dominant polycystic kidney disease with a perinephritic abscess

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