Adjuvants

Young, Alan J.

doi:10.1016/j.cvfa.2019.08.005

Veterinary Clinics of North America: Food Animal Practice

2019

DOI: 10.1016/j.cvfa.2019.08.005

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Adjuvants

Alan J. Young

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Cited by 5 publications

(1 citation statement)

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“…Modern vaccinology focuses on searching for effective, safe and low-cost adjuvants 34 . As discussed above, the plant viruses/VLP and SPs could be promising candidates for contributing to the design of novel adjuvants.…”

mentioning

confidence: 99%

Plant virus particles with various shapes as potential adjuvants

Evtushenko

Ryabchevskaya

Nikitin

et al. 2020

Sci Rep

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Plant viruses are biologically safe for mammals and can be successfully used as a carrier/platform to present foreign epitopes in the course of creating novel putative vaccines. However, there is mounting evidence that plant viruses, their virus-like and structurally modified particles may also have an immunopotentiating effect on antigens not bound with their surface covalently. Here, we present data on the adjuvant properties of plant viruses with various shapes (Tobacco mosaic virus, TMV; Potato virus X, PVX; Cauliflower mosaic virus, CaMV; Bean mild mosaic virus, BMMV) and structurally modified TMV spherical particles (SPs). We have analysed the effectiveness of immune response to individual model antigens (ovalbumin, OVA/hen egg lysozyme, HEL) and to OVA/HEL in compositions with plant viruses/SPs, and have shown that CaMV, TMV and SPs can effectively induce total IgG titers to model antigen. Some intriguing data were obtained when analysing the immune response to the plant viruses/SPs themselves. Strong immunity was induced to CaMV, BMMV and PVX, whereas TMV and SPs stimulated considerably lower self-IgG titers. Our results provide new insights into the immunopotentiating properties of plant viruses and can be useful in devising adjuvants based on plant viruses.

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mentioning

confidence: 99%

Plant virus particles with various shapes as potential adjuvants

Evtushenko

Ryabchevskaya

Nikitin

et al. 2020

Sci Rep

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Single-walled carbon nanotube-protein complex: A strategy to improve the immune response to protein in mice

Li,

Sui,

Wang

et al. 2024

Vaccine

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Immune and experimental infection responses of dairy cows vaccinated with the combination of six Staphylococcus aureus proteins that are expressed during bovine intramammary infection and a triple adjuvant

Ster

Allard

Côté-Gravel

et al. 2021

Veterinary Immunology and Immunopathology

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Adjuvants

Cited by 5 publications

References 63 publications

Plant virus particles with various shapes as potential adjuvants

Plant virus particles with various shapes as potential adjuvants

Single-walled carbon nanotube-protein complex: A strategy to improve the immune response to protein in mice

Immune and experimental infection responses of dairy cows vaccinated with the combination of six Staphylococcus aureus proteins that are expressed during bovine intramammary infection and a triple adjuvant

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