2021
DOI: 10.7326/l21-0104
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Administration of a Second Dose of the Moderna COVID-19 Vaccine After an Immediate Hypersensitivity Reaction With the First Dose: Two Case Reports

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Cited by 38 publications
(47 citation statements)
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“…Table 2. Protocol for graded administration of second dose of CoronaVac 21,27 Step* Dose and Concentration 1 0.05 mL of 1:10 vaccine dilution** 2 0.05 mL of full-strength vaccine 3 0.1 mL of full-strength vaccine 4 0.15 mL of full-strength vaccine 5 0.2 mL of full-strength vaccine…”
Section: Resultsmentioning
confidence: 99%
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“…Table 2. Protocol for graded administration of second dose of CoronaVac 21,27 Step* Dose and Concentration 1 0.05 mL of 1:10 vaccine dilution** 2 0.05 mL of full-strength vaccine 3 0.1 mL of full-strength vaccine 4 0.15 mL of full-strength vaccine 5 0.2 mL of full-strength vaccine…”
Section: Resultsmentioning
confidence: 99%
“…Our graded dosing protocol has been adapted from the practice parameter about adverse reactions to vaccines which was published in 2012 (21). In a recent report, a similar protocol was safely used on two patients who experienced an IHR with the first dose of the Moderna COVID-19 vaccine (27).…”
Section: Discussionmentioning
confidence: 99%
“…Ainsi, notre protocole d’induction de tolérance au vaccin COMIRNATY®, est une version inspirée à la fois du protocole de Kelso et al pour les vaccins classiques [5] , de celui de Mustapha pour le vaccin Moderna [6] et de celui d’Erdeljic Turk et al pour les vaccins à ARN [11] , adapté pour une dose vaccinale de 0,3 mL. Le Tableau 2 permet une comparaison de notre protocole à ceux de Kelso et al et Erdeljic Turk et al…”
Section: Discussionunclassified
“…En termes d’efficacité vaccinale, le fractionnement des doses a démontré, comme dans l’étude de Mustafa et al pour le vaccin Moderna [6] , une élévation des IgG anti-spike chez notre patient. À l’instar des administrations monodoses de vaccin, cette séroconversion présage d’une efficacité vaccinale, néanmoins sans certitude démontrable en l’état actuel des connaissances.…”
Section: Discussionunclassified
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