Administration of human chorionic gonadotropin at embryo transfer induced ovulation of a first wave dominant follicle, and increased progesterone and transfer pregnancy rates

Wallace, L. D.; Breiner, C.A.; Breiner, R.A.; Spell, A.R.; Carter, J.A.; Lamb, G. C.; Stevenson, Jeffrey S.

doi:10.1016/j.theriogenology.2010.12.012

Cited by 27 publications

(14 citation statements)

References 39 publications

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“…In the current study, response rates using Ovsynch were well below expected outcomes (63.3 vs. 87%). Success rates in previous reports using hCG to cause a spontaneous ovulation and induce an acces-sory CL were approximately 70% (Wallace et al, 2011;Stevenson and Pulley, 2012). The observed response in the current study to hCG to induce an accessory CL (36%) was also less than expected.…”

Section: Discussioncontrasting

confidence: 68%

Effect of 2 corpora lutea on blood perfusion, peripheral progesterone, and hepatic steroid-inactivating enzymes in dairy cattle

Voelz

Cline

Hart

et al. 2015

Journal of Dairy Science

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The luteal structure that develops postovulation is critical to the facilitation and maintenance of pregnancy in dairy cattle. The objectives of this experiment were to determine if the induction of an accessory corpus luteum (CL), via human chorionic gonadotropin, altered blood perfusion of CL, peripheral concentrations of progesterone, or hepatic steroid-inactivating enzymes. Twenty-eight late-lactation Holstein cows were synchronized using the Ovsynch protocol and randomly assigned to 1 of 2 treatment groups. Cows received either an injection of human chorionic gonadotropin (1,000IU, i.m.) to induce an accessory CL (cows had exactly 2CL in 1 ovary) or no treatment (cows had exactly 1CL). Corpora lutea were examined daily from d 10 to 18 (d 0 was induced ovulation) via Doppler ultrasonography and a blood sample was collected. Volume of the CL was recorded, as well as images and videos of each CL, which were analyzed for blood perfusion. On d 13, a liver biopsy was performed to analyze hepatic steroid-inactivating enzymes. Cows with 1 or 2CL had similar peripheral concentrations of progesterone. Cows with 2CL had similar luteal volumes to cows with 1CL but cows with 2CL had greater total luteal blood perfusion. Hepatic enzyme [cytochrome P450 (CYP) 1A, 3A, and 2C, aldo-keto reductase 1C, and uridine diphosphate glucuronosyltransferase] activities did not differ between cows with 1 and 2CL. Overall, the observed increase in total luteal blood perfusion in cows with 2CL did not correspond to differences in peripheral concentrations of progesterone or clearance of progesterone measured by the hepatic enzyme activity. This could indicate that induction of an accessory CL would not affect concentrations of progesterone necessary to maintain pregnancy.

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Section: Discussioncontrasting

confidence: 68%

Effect of 2 corpora lutea on blood perfusion, peripheral progesterone, and hepatic steroid-inactivating enzymes in dairy cattle

Voelz

Cline

Hart

et al. 2015

Journal of Dairy Science

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“…Wallace et al [13] demonstrated improved pregnancy rates after an intramuscular injection of hCG at ET in cows. In a study by Banerjee and Fazleabas [14], intrauterine injection of hCG in baboons induced a favorable uterine environment for embryo implantation.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic administration of hCG at embryo transfer (ET) has resulted in an increased pregnancy rate in animal models [13]. Intrauterine injection of hCG has been associated with significant pro-implantation changes of the endometrium in primates [14].…”

Section: Introductionmentioning

confidence: 99%

In vitro Fertilization Outcome following Embryo Transfer with or without Preinstillation of Human Chorionic Gonadotropin into the Uterine Cavity: A Randomized Controlled Trial

Aaleyasin

Aghahosseini

Rashidi

et al. 2014

Gynecol Obstet Invest

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Background: Intrauterine injection of human chorionic gonadotropin (hCG) at embryo transfer (ET) has been shown to improve the outcome of assisted reproductive techniques. The aim of this study was to confirm previous findings. Methods: In this randomized controlled trial, 483 infertile women who were candidates for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) for the first time were randomly assigned to receive an intrauterine injection of 500 IU hCG or placebo (tissue culture media) before ET. The main outcome measures were implantation and clinical pregnancy rates. Results: Both the hCG-treated group (n = 240) and control group (n = 243) were similar at baseline in terms of demographic and obstetrical characteristics.There were significant differences between the two groups regarding the implantation rate (23.6 vs. 12.2%, p < 0.001), pregnancy rate (54.6 vs. 35.8%, p < 0.001), clinical pregnancy rate (50 vs. 32.1%, p < 0.001), ongoing pregnancy rate (15.3 vs. 9.2%, p < 0.001) and live delivery rate (14.3 vs. 8.4%, p < 0.001). The rate of fertilization and abortion rates were not statistically different. Conclusion: Intrauterine injection of hCG before ET improves implantation and pregnancy rates and may be considered an adjuvant in IVF/ICSI.

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“…Small et al (2004) were also unable to improve pregnancy rates in Bos taurus recipients treated with GnRH or pLH on Days 5 or 7 after oestrus. In a very recent study (Wallace et al 2011), 719 beef recipients alternately received 1000 IU hCG or saline (control) at the time of embryo transfer. Serum progesterone concentrations at pregnancy diagnoses in pregnant cows were higher after hCG treatment than in controls, and conception rates were 61.8 and 53.9% for hCG and control groups, respectively.…”

Section: Other Treatments Designed To Increase Pregnancy Rates In Recmentioning

confidence: 99%

Treatments for the synchronisation of bovine recipients for fixed-time embryo transfer and improvement of pregnancy rates

Bó

Peres²,

Cutaia³

et al. 2012

Reprod. Fertil. Dev.

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Although embryo transfer technology has been used commercially in cattle for many years, the inefficiency of oestrus detection, especially in recipients, has limited the widespread application of this technology. The most useful alternative to increase the number of recipients utilised in an embryo transfer program is the use of protocols that allow for embryo transfer without the need for oestrus detection, usually called fixed-time embryo transfer (FTET). Most current FTET protocols are based on progestin-releasing devices combined with oestradiol or GnRH, which control and synchronise follicular wave dynamics and ovulation. Conception rates to a single FTET have been reported to be similar to those after detection of oestrus, but pregnancy rates are higher because these treatments have increased the proportion of recipients that receive an embryo. Recent changes to treatments for FTET, such as the administration of eCG, have resulted in increased pregnancy rates and provide opportunities to make these treatments easier to perform on farm.

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Administration of human chorionic gonadotropin at embryo transfer induced ovulation of a first wave dominant follicle, and increased progesterone and transfer pregnancy rates

Abstract: Theriogenology 75 (2011) 1506-1515. doi:10.1016/j.theriogenology.2010.12.012Received by publisher: 2010-08-02Harvest Date: 2016-01-04 12:21:09DOI: 10.1016/j.theriogenology.2010.12.012Page Range: 1506-151

Cited by 27 publications

References 39 publications

Effect of 2 corpora lutea on blood perfusion, peripheral progesterone, and hepatic steroid-inactivating enzymes in dairy cattle

Effect of 2 corpora lutea on blood perfusion, peripheral progesterone, and hepatic steroid-inactivating enzymes in dairy cattle

In vitro Fertilization Outcome following Embryo Transfer with or without Preinstillation of Human Chorionic Gonadotropin into the Uterine Cavity: A Randomized Controlled Trial

Treatments for the synchronisation of bovine recipients for fixed-time embryo transfer and improvement of pregnancy rates

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