Administration of valine, leucine, and isoleucine improved plasma cholesterol and mitigated the preatherosclerotic lesions in rats fed with hypercholesterolemic diet

Abstract

Hypercholesterolemia has a major contribution to the occurrence and progression of atherosclerotic lesions. Recent

Modulation of Disordered Bile Acid Homeostasis and Hepatic Tight Junctions Using Salidroside against Hepatocyte Apoptosis in Furan-Induced Mice

“…The potential mechanism of furan-induced hepatocyte apoptosis was discussed based on the metabolites and pathways (Table and Figure C–F). Previous research has displayed that valine, leucine, and isoleucine can improve the cholesterol level, 7α-Hydroxy-3-oxo-4-cholestenoate is related to the initiation of the synthesis, and cholic acid is conjugated with taurine or glycine before secretion. In addition, bilirubin, fluvastatin, and bile salts are included in the pathway of bile secretion, and this pathway is associated with primary bile acid biosynthesis and the tight junction.…”

Hypolipemiant Actions and Possible Cardioprotective Effects of Valine and Leucine: An Experimental Study

“…In a study performed in 2018, we assessed the role of valine, leucine and isoleucine on the occurrence and progression of atherosclerosis in rats receiving hypercholesterolic diet. The comparative study of the three essential amino acids revealed that valine induced a faster response than leucine and isoleucine on the improvement of biochemical parameters, but no significant differences between the three amino acids in terms of their protective ability, according to the histopathological lesion assessment [ 26 ]. Still, further studies in order to assess the precise molecular mechanism by which these amino acids influence the triglyceride levels are necessary.…”

In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug

“…In its turn, it is known that L-glutamine with L-alanine or as a dipeptide is able to induce cytoprotective effects mediated by heat shock protein 70 (HSP70)-associated responses to muscle damage and inflammation [ 37 ]. Isoleucine is known for its protective ability having a beneficial contribution to the vascular wall [ 38 ]. Carnosine possesses a broad range of protective properties, including hypoglycemic, anti-inflammatory, and anti-oxidative effects [ 39 ].…”