Admission biochemical test associated with the prognosis of COVID-19: a multi-centered retrospective cohort study

Abstract

Objectives: Since December 2019, a outbreak of Corona Virus Disease-2019(COVID-19) started in Wuhan, China. Now we comprehended much more about the troublesome disease from studies than the beginning. But more details between admission laboratory test and prognosis of COVID-19 were still confusing. So we focused on the admission biochemical test, and tried to verify their influence to the prognosis of COVID-19.Method: 522 patients from 4 hospitals were enrolled in this retrospective cohort study. We collected demographic information, comorbidities and laboratory biochemical indicators, then compared them between survivors’ and nonsurvivors’ group. Logistic regression methods were used to explore the risk factors associated with in-hospital death. Linear regression and receiver operating characteristic curve(ROC-curve) was applied to assess the efficiency of risk factors and regression model.Results:Age of nonsurvivors’ group(68.9) was older than survivors group(50.0). Diabetes(68.7%) was the most common comorbidity in the nonsurvivors’ group. In univariate regression analysis, most biochemical tests were related to the mortality except lipid metabolic results. Age, fasting blood glucose and blood urea nitrogen(BUN) were with a p-value less than 0.001 in multivariate regression model.Conclusion:Age, BUN and fasting blood glucose were risk factors associated with the prognosis of COVID-19 related pneumonia.Authors Qi Long, Chen-liang Zhou, Ye-ming Wang, Bin Song, Xiao-bin Cheng, Qiu-fen Dong, and Liu-lin Wang contributed equally to this work.

High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis

“…Although our findings also favored the use of admission RBG, future research are required as we were unable to comprehensively explore the independent prognostic value of admission RBG due to paucity of studies. Furthermore, the current evidence indicated that the cut-off values to predict poor prognosis in COVID-19 patients are still equivocal [38,41,52,53], suggesting that future large multicenter studies are required to obtain the most optimum cut-off value.…”

Elevated D-dimer levels on admission are associated with severity and increased risk of mortality in COVID-19: A systematic review and meta-analysis

“…Thirty-nine studies compared the D-dimer levels between a total of 5759 severe and 2063 non-severe patients . Sixteen studies compared the D-dimer levels between a total of 2783 surviving and 697 non-surviving patients [39,[55][56][57][58][59][60][61][62][63][64][65][66][67][68][69]. All the studies except for one were performed outside China [64].…”

High admission blood glucose is an independent risk factor of poor prognosis in COVID-19: A systematic review and dose-response meta-analysis

“…Although our findings also favored over the use of admission RBG, future researches are required as we were unable to comprehensively explore the independent prognostic value of admission RBG due to paucity of studies. Furthermore, the current evidence indicated that the cut-off values to predict poor prognosis in COVID-19 patients are still equivocal 31,34,50,51 , suggesting that future large multicenter studies are required to obtain the most optimum cut-off value.…”