Admission Heart Rate Variability is Associated with Fever Development in Patients with Intracerebral Hemorrhage

Swor, Dionne E.; Thomas, Leena; Maas, Matthew B.; Grimaldi, Daniela; Sorond, Farzaneh A.; Batra, Ayush; Kim, Minjee; Naidech, Andrew M.; Liotta, Eric M.

doi:10.1007/s12028-019-00684-w

Cited by 19 publications

(21 citation statements)

References 32 publications

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“… Swor et al (2019) analyzed the association between HRV and development of fever in patients with ICH. Lower SDNN occurred in patients with fever (SDNN: 1.72 vs. 2.55, p = 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…The authors commented that VLF HRV, an index of integrative autonomic-humoral control, could be considered as a biomarker of infection in the immediate post-stroke period. Swor et al (2019) analyzed the association between HRV and development of fever in patients with ICH. Lower SDNN occurred in patients with fever (SDNN: 1.72 vs. 2.55, p = 0.001).…”

Section: Infectionsmentioning

confidence: 99%

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Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review

et al. 2023

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Background: Heart rate variability (HRV) is a non-invasive marker of autonomic nervous system function that is based on the analysis of length differences between subsequent RR intervals of the electrocardiogram. The aim of this systematic review was to assess the current knowledge gap in the utility of HRV parameters and their value as predictors of the acute stroke course.Methods: A systematic review was performed in accordance with the PRISMA guidelines. Relevant articles published between 1 January 2016 and 1 November 2022 available in the PubMed, Web of Science, Scopus, and Cochrane Library databases were obtained using a systematic search strategy. The following keywords were used to screen the publications: “heart rate variability” AND/OR “HRV” AND “stroke.” The eligibility criteria that clearly identified and described outcomes and outlined restrictions on HRV measurement were pre-established by the authors. Articles assessing the relationship between HRV measured in the acute phase of stroke and at least one stroke outcome were considered. The observation period did not exceed 12 months. Studies that included patients with medical conditions influencing HRV with no established stroke etiology and non-human subjects were excluded from the analysis. To minimize the risk of bias, disagreements throughout the search and analysis were resolved by two independent supervisors.Results: Of the 1,305 records obtained from the systematic search based on keywords, 36 were included in the final review. These publications provided insight into the usability of linear and non-linear HRV analysis in predicting the course, complications, and mortality of stroke. Furthermore, some modern techniques, such as HRV biofeedback, for the improvement of cognition performance after a stroke are discussed.Discussion: The present study showed that HRV could be considered a promising biomarker of a stroke outcome and its complications. However, further research is needed to establish a methodology for appropriate quantification and interpretation of HRV-derived parameters.

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“… Swor et al (2019) analyzed the association between HRV and development of fever in patients with ICH. Lower SDNN occurred in patients with fever (SDNN: 1.72 vs. 2.55, p = 0.001).…”

Section: Resultsmentioning

confidence: 99%

Section: Infectionsmentioning

confidence: 99%

Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review

et al. 2023

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“…Our results are in line with prior studies that reported decreased HRV in patients with sepsis [ 10 ], trauma [ 12 ], and other critical illnesses [ 29 - 31 ]. In severe acute brain injury, many studies have documented the association between HRV and clinical outcomes, including intracranial hemorrhage [ 32 ], subarachnoid hemorrhage [ 20 ], traumatic brain injury [ 13 , 14 , 33 - 35 ], ischemic stroke [ 36 ], brain metastasis [ 37 ], multiple etiologies of acute brain injury [ 38 ], neurosurgical patients [ 39 ], and brain death [ 15 , 16 , 40 - 42 ]. Thus, autonomic dysfunction represented by HRV seems to occur in severely brain-injured patients and is also related to poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

Continuous heart rate variability and electroencephalography monitoring in severe acute brain injury: a preliminary study

2021

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Background: Decreases in heart rate variability have been shown to be associated with poor outcomes in severe acute brain injury. However, it is unknown whether the changes in heart rate variability precede neurological deterioration in such patients. We explored the changes in heart rate variability measured by electrocardiography in patients who had neurological deterioration following severe acute brain injury and examined the relationship between heart rate variability and electroencephalography parameters. Methods: Retrospective analysis of 25 patients who manifested neurological deterioration after severe acute brain injury and underwent simultaneous electroencephalography plus electrocardiography monitoring. Results: Eighteen electroencephalography channels and one simultaneously recorded electrocardiography channel were segmented into epochs of 120-second duration and processed to compute 10 heart rate variability parameters and three quantitative electroencephalography parameters. Raw electroencephalography of the epochs was also assessed by standardized visual interpretation and categorized based on their background abnormalities and ictal-interictal continuum patterns. The heart rate variability and electroencephalography parameters showed consistent changes in the 2-day period before neurological deterioration commenced. Remarkably, the suppression ratio and background abnormality of the electroencephalography parameters had significant reverse correlations with all heart rate variability parameters. Conclusions: We observed a significantly progressive decline in heart rate variability from the day before the neurological deterioration events in patients with severe acute brain injury were first observed.

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“…There are different cholinergic receptor blockers, such as atropine (ATR) [15], penehyclidine hydrochloride (PHC) and methyllycaconitine (MLA). ATR is a non-selective antagonist of muscarinic receptors [16,17].…”

Section: Introductionmentioning

confidence: 99%

Cholinergic receptor blockers affect the protective effect of Angong Niuhuang pill on neurologic deficits and intestinal injury in intracerebral hemorrhage mice

Yang

Wang

Yue

et al. 2021

J Pharm Biopharm Res

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Stroke is a devastating disease, intracerebral hemorrhage (ICH) is a devastating subtype. This study aimed to investigate whether cholinergic receptors participate in the process of Angong Niuhuang Pill (ANP) improving neurological function and relieving intestinal injury in ICH mice. The mice were treated with ANP, cholinergic receptor blockers, atropine (ATR), penehyclidine hydrochloride (PHC) or methyllycaconitine (MLA). Male CD-1 mice were randomly divided into 9 groups, Sham, ICH, ANP (0.2 g/kg), ANP plus ATR, ANP plus PHC, ANP plus MLA, ATR, PHC, MLA. ICH model is made by collagenase VII injection (0.075 U). ANP (0.2 g/kg) was administered by gavage after 30 min of ICH. MLA, ATR, PHC was given at 15 min after ICH. Neurological function was evaluated by Garcia test. Intestinal injury was observed by histological analysis. Endotoxin (ET) was measured by enzyme-linked immunosorbent assay. Compared to the Sham group, the score of Garcia test in the ICH significantly decreased. ANP increased significantly the score of ICH mice. ANP also ameliorated the intestinal injury caused by ICH. Cholinergic receptor blockers reversed partially the improvement of neurological function and intestinal injury by ANP. ANP attenuates the neurological deficits and intestinal injury in ICH mice and the protective effect of ANP may be involved in the regulation of the cholinergic system.

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Admission Heart Rate Variability is Associated with Fever Development in Patients with Intracerebral Hemorrhage

Cited by 19 publications

References 32 publications

Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review

Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review

Continuous heart rate variability and electroencephalography monitoring in severe acute brain injury: a preliminary study

Cholinergic receptor blockers affect the protective effect of Angong Niuhuang pill on neurologic deficits and intestinal injury in intracerebral hemorrhage mice

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