Adolescent boys with constitutional delay of growth and puberty grow faster than patients with organic growth hormone deficiency

Binder, Gerhard; Lehrian, Theresa Johanna; Hoffmann, Elisa; Blumenstock, Gunnar; Rahmaoui, Abdelkader; Trzaskoma, Benjamin; Reinehr, Thomas

doi:10.1111/cen.14358

Cited by 3 publications

(1 citation statement)

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“…However, unlike patients with CDGP, our patients had poor growth velocities in addition to short stature for age or family, while puberty was progressing (33). This is further supported by a study from Binder et al who compared growth velocities in patients with CDGP and organic GHD from National Cooperative Growth Study (NCGS) registry (n=164) (34). They found that patients with organic GHD had significantly lower height velocity of 3.5 ± 3.2 cm/year compared to height velocity of 5.2 ± 5.4 cm/year in those with CDGP (p <.0001) at 14.1 ± 0.4 age.…”

Section: Discussionsupporting

confidence: 77%

Evolving growth hormone deficiency: proof of concept

Chimatapu,

Sethuram,

Samuels

et al. 2024

Front. Endocrinol.

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IntroductionWe present the evolution of GHD in adolescent males with persistent growth failure, in whom the diagnosis was established after a second GH stimulation test (GST).MethodsWe performed a retrospective chart review of children who presented for short stature (height less < 2SD for mean/mid-parental height) and/or growth failure (sustained growth velocity < 0 SD) to pediatric endocrinology at Mount Sinai Kravis Children’s Hospital, New York and who had 2 GSTs. Data collected from electronic medical records were analyzed using SPSS v28.0ResultsOf 53 patients included, 42 were males. Average GH peak on initial GST was 15.48 ± 4.92 ng/ml, at 10.07 ± 2.65 years, mean height -1.68 ± 0.56SD(28% had <2SD), IGF-1 -1.00 ± 0.88SD. After 2.23 ± 1.22 years, at 12.04 ± 2.41years, height SDs decreased to -1.82 ± 0.63SD and IGF-1 was -1.08 ± 0.84SD. At repeat GST, average GH peak was 7.59 ± 2.12 ng/dL, with 36% ≤7 ng/dl and 32% in puberty. 12 males reached adult height of 0.08 ± 0.69 SD with a mean height gain of 1.83 ± 0.56SD(p<0.005), IGF-1 of -1.15 ± 0.81SD after 4.64 ± 1.4 years of GH.ConclusionWe offer evidence for Evolving Growth Hormone Deficiency (EGHD) through repeat GST in children with persistent growth slowdown, even with pubertal progression; emphasizing the need for careful longitudinal follow-up to make accurate diagnosis.

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Section: Discussionsupporting

confidence: 77%