The present study examined (a) whether groups of children can be empirically identified with distinct longitudinal profiles of depressed mood from late childhood through early adolescence, (b) to what extent these different longitudinal depression profiles are predicted by problematic relations with parents, same-sex peers, and other-sex peers, and (c) what role individuals' temperamental characteristics play in this context. Based on a sample of 414 early adolescents (197 girls), four groups were identified with distinct longitudinal profiles of depressed mood between ages 11 and 14: One group with consistently low levels of depressed mood, another with consistently moderate levels of depressed mood, a third group whose depressed mood increased sharply from late childhood through early adolescence, and a fourth group who already showed clinical-range levels of depressed mood during late childhood and whose depressive feelings increased even slightly more thereafter. Subsequent analyses revealed that rejection by same-sex peers was related to the odds of following an increasing trajectory of depressed mood, but only for girls with a highly reactive temperament. A problematic relationship with parents increased the odds of an elevated trajectory of depressed mood regardless of individual temperament. The theoretical and practical implications of these findings are discussed.