Adoptive T-cell Therapy in the Treatment of Viral and Opportunistic Fungal Infections

Mancini, Nicasio; Marrone, Lara; Clementi, Nicola; Clementi, Massimo; Burioni, Roberto

doi:10.2217/fmb.14.122

Cited by 7 publications

(7 citation statements)

References 123 publications

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“…Currently, genome-wide studies, together with novel T-cell-based therapeutic approaches for the prophylaxis and treatment of opportunistic fungal infections, have promising avenues of research in the detection of potentially new antifungal targets. 81 , 82 Thus, different strategies should be the main goals of the pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review

Ribas

Spolti

Ponte

et al. 2016

Brazilian Journal of Microbiology

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Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments.

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Section: Introductionmentioning

confidence: 99%

Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review

Ribas

Spolti

Ponte

et al. 2016

Brazilian Journal of Microbiology

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“…Unfortunately, not every disease can currently be prevented through vaccines. However, many strategies have been developed against infectious agents, such as the generation of neutralizing antibodies, antibiotics, and antiviral drugs [124–130], and innovative approaches are currently under development [131–133].…”

Section: Discussionmentioning

confidence: 99%

Alternative Methods of Vaccine Delivery: An Overview of Edible and Intradermal Vaccines

Criscuolo

Caputo

Diotti

et al. 2019

Journal of Immunology Research

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Vaccines are recognized worldwide as one of the most important tools for combating infectious diseases. Despite the tremendous value conferred by currently available vaccines toward public health, the implementation of additional vaccine platforms is also of key importance. In fact, currently available vaccines possess shortcomings, such as inefficient triggering of a cell-mediated immune response and the lack of protective mucosal immunity. In this regard, recent work has been focused on vaccine delivery systems, as an alternative to injectable vaccines, to increase antigen stability and improve overall immunogenicity. In particular, novel strategies based on edible or intradermal vaccine formulations have been demonstrated to trigger both a systemic and mucosal immune response. These novel vaccination delivery systems offer several advantages over the injectable preparations including self-administration, reduced cost, stability, and elimination of a cold chain. In this review, the latest findings and accomplishments regarding edible and intradermal vaccines are described in the context of the system used for immunogen expression, their molecular features and capacity to induce a protective systemic and mucosal response.

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“…In any case the employment of CARs is not restricted to cancer therapy. A variety of CARs have been used to treat different pathologies such as viral or fungal infections [6] and autoimmune diseases, the main aspect reviewed in this article.…”

Section: Review Articlementioning

confidence: 99%

Future of Chimeric Antigen Receptors (Cars): Could it Drive Solutions Beyond Cancer? Examples in Autoimmune Diseases

Español-Rego¹,

Marzal²,

Llobell³

et al. 2017

MOJI

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Adoptive T-cell Therapy in the Treatment of Viral and Opportunistic Fungal Infections

Cited by 7 publications

References 123 publications

Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review

Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review

Alternative Methods of Vaccine Delivery: An Overview of Edible and Intradermal Vaccines

Future of Chimeric Antigen Receptors (Cars): Could it Drive Solutions Beyond Cancer? Examples in Autoimmune Diseases

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