2018
DOI: 10.1007/978-3-319-91137-3_21
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Adrenal Medulla Chemo Sensitivity Does Not Compensate the Lack of Hypoxia Driven Carotid Body Chemo Reflex in Guinea Pigs

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“…CIH exposure did not alter hypoxia elicited time course of E and NE adrenal outflow from in vitro AM. The lack of response of adult in vitro AM to hypoxia was expected from previously published findings in adrenomedullary cells from rats ( Seidler and Slotkin, 1985 ; Thompson et al, 1997 ) and from our own data in guinea pigs ( Olea et al, 2018 ). However, Prabhakar’s group reported that CIH induced oxidative stress and facilitates catecholamine efflux from the AM slices in adult rats ( Kumar et al, 2015 ).…”
Section: Discussionsupporting
confidence: 74%
“…CIH exposure did not alter hypoxia elicited time course of E and NE adrenal outflow from in vitro AM. The lack of response of adult in vitro AM to hypoxia was expected from previously published findings in adrenomedullary cells from rats ( Seidler and Slotkin, 1985 ; Thompson et al, 1997 ) and from our own data in guinea pigs ( Olea et al, 2018 ). However, Prabhakar’s group reported that CIH induced oxidative stress and facilitates catecholamine efflux from the AM slices in adult rats ( Kumar et al, 2015 ).…”
Section: Discussionsupporting
confidence: 74%