Adrenergic Immune Effects: Is Beta the Enemy of Good?*

Deutschman, Clifford S.; Leisman, Daniel E.; Taylor, Matthew D.

doi:10.1097/ccm.0000000000005524

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…In this multidisciplinary inter-collaborative scenario, curation of selected evidence is paramount to guide transversal action. We recognize the inherent limitations of in vitro studies, the controversy surrounding the verisimilitude of administering LPS (Osuchowski et al, 2018) or using cecal ligation and puncture (CLP) (Deutschman et al, 2022) as animal models of sepsis, as well as the 10.3389/fmicb. 2023.1198200 Frontiers in Microbiology 15 frontiersin.org impossibility of calculating factual figures of incidence and mortality worldwide (Rudd et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Novel evidence on sepsis-inducing pathogens: from laboratory to bedside

Gatica,

Fuentes,

Rivera-Asín

et al. 2023

Front. Microbiol.

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Sepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, along with fungal pathogens of the Candida species. Here, we focus on evidence from human studies but also include in vitro and in vivo cellular and molecular evidence, exploring how bacterial and fungal pathogens are associated with bloodstream infection and sepsis. This review presents a narrative update on pathogen epidemiology, virulence factors, host factors of susceptibility, mechanisms of immunomodulation, current therapies, antibiotic resistance, and opportunities for diagnosis, prognosis, and therapeutics, through the perspective of bloodstream infection and sepsis. A list of curated novel host and pathogen factors, diagnostic and prognostic markers, and potential therapeutical targets to tackle sepsis from the research laboratory is presented. Further, we discuss the complex nature of sepsis depending on the sepsis-inducing pathogen and host susceptibility, the more common strains associated with severe pathology and how these aspects may impact in the management of the clinical presentation of sepsis.

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Section: Discussionmentioning

confidence: 99%