Adrenergic signaling elements in the bladder wall of the adult rat

Persyn, Sara; Eastham, Jane; Wachter, Stefan De; Gillespie, James

doi:10.1016/j.autneu.2016.09.002

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…Similarly, transection of hypogastric nerves had no effect on the inhibition of RMCs by noxious pinching stimulation of perineal skin in anesthetized rats and cats (Sato et al, 1975(Sato et al, , 1997. These results are in accord with reports that there is only sparse adrenergic innervation of the detrusor body in both rats and humans, suggesting little sympathetic regulation of bladder contractility (Watanabe and Yamamoto, 1979;Gosling et al, 1999) smooth muscle, possibly via a nonneuronal β-adrenergic system (Persyn et al, 2016). These results indicate that parasympathetic pelvic nerves are the primary mediator of micturition reflex inhibition by perineal somatic inputs.…”

Section: Neural Mechanisms Of Rmc Inhibition By Gentle Stimulation Efsupporting

confidence: 91%

“…These results are in accord with reports that there is only sparse adrenergic innervation of the detrusor body in both rats and humans, suggesting little sympathetic regulation of bladder contractility (Watanabe and Yamamoto, ; Gosling et al, ). However, low doses of adrenergic agonists are still capable of relaxing the bladder smooth muscle, possibly via a nonneuronal β‐adrenergic system (Persyn et al, ). These results indicate that parasympathetic pelvic nerves are the primary mediator of micturition reflex inhibition by perineal somatic inputs.…”

Section: Neural Mechanisms Of Rmc Inhibition By Gentle Stimulationmentioning

confidence: 99%

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Gentle Perineal Skin Stimulation for Control of Nocturia

Hotta

Watanabe

2019

The Anatomical Record

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One of the major causes of nocturia is overactive bladder (OAB). Somatic afferent nerve stimuli are used for treating OAB. However, clinical evidence for the efficacy of this treatment is insufficient due to the lack of appropriate control stimuli. Studies on anesthetized animals, which eliminate emotional factors and placebo effects, have demonstrated an influence of somatic stimuli on urinary bladder functions and elucidated the underlying mechanisms. In general, the effects of somatic stimuli are dependent on the modality, location, and physical characteristics of the stimulus. Recently we showed that gentle stimuli applied to the perineal skin using a soft elastomer roller inhibited micturition contractions to a greater extent than a roller with a hard surface. Studies aiming to elucidate the neural mechanisms of gentle stimulation‐induced inhibition reported that 1–10 Hz discharges of low‐threshold cutaneous mechanoreceptive Aβ, Aδ, and C fibers evoked during stimulation with an elastomer roller inhibited the micturition reflex by activating the spinal cord opioid system, thereby reducing both ascending and descending transmission between bladder and pontine micturition center. The present review will provide a brief summary of (1) the effect of somatic electrical stimulation on the micturition reflex, (2) the effect of gentle mechanical skin stimulation on the micturition reflex, (3) the afferent, efferent, and central mechanisms underlying the effects of gentle stimulation, and (4) a translational clinical study demonstrating the efficacy of gentle skin stimuli for treating nocturia in the elderly with OAB by using the two roller types inducing distinct effects on rat micturition contractions. Anat Rec, 302:1824–1836, 2019. © 2019 American Association for Anatomy

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Section: Neural Mechanisms Of Rmc Inhibition By Gentle Stimulation Efsupporting

confidence: 91%

Section: Neural Mechanisms Of Rmc Inhibition By Gentle Stimulationmentioning

confidence: 99%

Gentle Perineal Skin Stimulation for Control of Nocturia

Hotta

Watanabe

2019

The Anatomical Record

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“…However, in some species, including human, sympathetic nerve fibres predominantly innervate the blood vessels, and there is only a sparse adrenergic innervation of the detrusor. 32,33 This anatomical evidence is consistent with the fact that sympathetic nerve-mediated, β-adrenergic relaxations of DSM strips are hardly detected, while sympathetic α-adrenergic constrictions of submucosal blood vessels are readily detected in in vitro studies. The expression of β-receptors in these species may indicate an endocrine influence.…”

supporting

confidence: 82%

What are the origins and relevance of spontaneous bladder contractions? ICI‐RS 2017

Drake

Fry

Hashitani

et al. 2018

Neurourology and Urodynamics

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“…Langworthy is possibly the second major provider of evidence for an inhibitory action of the lumbar pathway on the bladder, by demonstrating, in cats, a diminished vesical capacity after hypogastric nerve transection [ 33 ]. Yet, he later failed to find any sympathetic fibers in the detrusor muscle [ 34 ] (followed in this by many others [ 35 – 38 ]) and eventually turned into the bluntest critic of the lumbosacral antagonism on the bladder [ 39 ]: “Section of the sympathetic fibers has no significant effect on the urinary bladder, which acts as well as ever. Section of the parasympathetic fibers paralyzes the bladder completely.” De Groat et al [ 40 ] (also on cat) is a later notable contribution to the “lumbar inhibition” case.…”

Section: The Physiological Argumentsmentioning

confidence: 99%

“…The shift towards purely pharmacological experiments in the 1970s, highlighting alpha- and beta-adrenergic receptors in different parts of the bladder and under different physiopathological conditions, is built on the notion of a sympathetic lumbar inhibitory pathway without providing further evidence for its reality. Local non-neuronal sources of adrenalin have been recently proposed [ 38 ].…”

Section: The Physiological Argumentsmentioning

confidence: 99%

The “sacral parasympathetic”: ontogeny and anatomy of a myth

et al. 2017

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We recently defined genetic traits that distinguish sympathetic from parasympathetic neurons, both preganglionic and ganglionic (Espinosa-Medina et al., Science 354:893–897, 2016). By this set of criteria, we found that the sacral autonomic outflow is sympathetic, not parasympathetic as has been thought for more than a century. Proposing such a belated shift in perspective begs the question why the new criterion (cell types defined by their genetic make-up and dependencies) should be favored over the anatomical, physiological and pharmacological considerations of long ago that inspired the “parasympathetic” classification. After a brief reminder of the former, we expound the weaknesses of the latter and argue that the novel genetic definition helps integrating neglected anatomical and physiological observations and clearing the path for future research.

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Adrenergic signaling elements in the bladder wall of the adult rat

Cited by 9 publications

References 24 publications

Gentle Perineal Skin Stimulation for Control of Nocturia

Gentle Perineal Skin Stimulation for Control of Nocturia

What are the origins and relevance of spontaneous bladder contractions? ICI‐RS 2017

The “sacral parasympathetic”: ontogeny and anatomy of a myth

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