Adrenocortical dysfunction in paracoccidioidomycosis: comparison between plasma β‐lipotrophin/adrenocorticotrophin levels and adrenocortical tests

Abstract

The frequency of Addison's disease among our patients with paracoccidioidomycosis was 10%. In addition, a subset of patients presented with adrenal dysfunction detected by mineralocorticoid or androgen tests. In parallel to pathological lesions a functional adaptation may occur during adrenal involvement in paracoccidioidomycosis.

Bilateral isolated adrenal coccidioidomycosis

“…Low serum DHEA-s was noted in the face of normal serum androstenedione concentration. This pattern of impairement has been previously noted in critically ill patients and recently in paracoccidioidomycosis [7,8].…”

Adrenal Failure due to Adrenal Metastasis of Lung Cancer: A Case Report

“…Its diagnosis was based on very low serum cortisol with increased serum ACTH [11]. The etiology of adrenal failure is more commonly autoimmune destruction of the glands in developed countries, but tuberculosis and paracoccidioidomycosis are still prevalent in South Brazil [12, 13]. The presence of pulmonary nodules and large masses in both adrenals suggest Addison's disease secondary to metastatic destruction of the glands.…”

Insuficiência adrenal primária no adulto: 150 anos depois de Addison

“…Outras infecções fúngicas sistêmicas que podem levar à falência adrenocortical são a histoplasmose, a criptococose e a coccidioidomicose (71). Em estudo relatado pelo nosso grupo na FMRP-USP (74), verificou-se a ocorrência de DA em 10,6% de pacientes com paracoccidioidomicose, caracterizada pela elevação dos valores basais de ACTH e baixas concentrações de cortisol após estímulo com ACTH . Ainda no referido estudo, observou-se, também, o aumento da atividade de renina plasmática (31%), redução da aldosterona plasmática (23%) e redução das concentrações plasmáticas de SDHEA (50%).…”