Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct

Liao, Song-Yan; Ho, J. C.; Tang, Florence

doi:10.1530/rep-10-0230

Cited by 25 publications

(34 citation statements)

References 27 publications

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“…Sperm contact is another factor that seems to enhance the expression of ADM [52]. Stimulating effects of ADM is blocked by the calcitonin-gene-related peptide (CGRP) receptor antagonist [53]. In line with these studies, it has been suggested that plasma and tubal levels of ADM are lower in patients with tubal ectopic pregnancy compared to those with a normal pregnancy [54].…”

Section: Adrenomedullinmentioning

confidence: 98%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

106

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With the advent of assisted reproductive technology in the past three decades, the clinical importance of fallopian tubes has been relatively overlooked. However, successful spontaneous conception requires normal function of the tube to provide not only a conduit for the gametes to convene and embryo to reach the uterine cavity, but also a physiologically optimized environment for fertilization and early embryonic development. In this review, after a brief description of normal human tubal anatomy and histology, we will discuss tubal transport and its principal effectors, including ciliary motion, muscular contractility and tubal fluid. Furthermore, we will discuss the ciliary ultrastructure and regulation of ciliary beat frequency by ovarian steroids, follicular fluid, angiotensin system, autonomic nervous system and other factors such as adrenomedullin and prostaglandins. In the last section, we describe the adverse impact of various pathological conditions, such as endometriosis, infection and smoking on tubal function and ciliary motility.

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Section: Adrenomedullinmentioning

confidence: 98%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

106

View full text Add to dashboard Cite

show abstract

“…Moreover, in the oviductal secretory cells, E 2 induces the production of cAMP, which promotes adrenomedullin activation (Liao et al 2013). In rats, adrenomedullin increases CBF by acting through the calcitonin-gene-related peptide (CGRP) receptor in the oviductal epithelial cells (Liao et al 2011). …”

Section: Ciliary Beatingmentioning

confidence: 99%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

209

191

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Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental regulation, oviductal fluid composition and its role in protecting embryos and supplying nutrients. Finally, the review compares different aspects of naturally occurring fertilization and assisted reproductive technology (ART)-achieved fertilization and embryo development, giving insight into potential areas for improvement in this technology.

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“…26 It is possible that this Adm 1/2 implantation phenotype is due in part to changes in ciliary beat frequency in the oviduct. 30,31 Embryos of Adm 1/2 dams are also more likely to die or demonstrate abnormalities symptomatic of poor placental perfusion during the development of the placenta between e9.5 and e12.5. 26 Furthermore, pathological placental morphologies observed in embryos developing within Adm 1/2 uteri exhibit aberrant invasion of Adm-expressing TGCs into the decidua.…”

Section: Maternal-derived Am Is Necessary For Successful Implantationmentioning

confidence: 99%

Adrenomedullin and endocrine control of immune cells during pregnancy

Matson

Caron

2014

Cell Mol Immunol

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The immunology of pregnancy is complex and incompletely understood. Aberrant immune activity in the decidua and in the placenta is believed to play a role in diseases of pregnancy, such as infertility, miscarriage, fetal growth restriction and preeclampsia. Here, we briefly review the endocrine control of uterine natural killer cell populations and their functions by the peptide hormone adrenomedullin. Studies in genetic animal models have revealed the critical importance of adrenomedullin dosage at the maternal-fetal interface, with cells from both the maternal and fetal compartments contributing to essential aspects underlying appropriate uterine receptivity, implantation and vascular remodeling of spiral arteries. These basic insights into the crosstalk between the endocrine and immune systems within the maternalfetal interface may ultimately translate to a better understanding of the functions and consequences of dysregulated adrenomedullin levels in clinically complicated pregnancies. Keywords: adrenomedullin; preeclampsia; pregnancy; spiral artery remodeling; uNK cells INTRODUCTION Pregnancy presents a mysterious immunological paradox that is permitted by the complex, unique immunology of the maternalfetal interface. We are only beginning to understand how this very specialized immune 'subsystem' differs from the systemic immune system and thus effectively protects the fetus from maternal rejection. For example, the sizable uterine natural killer (uNK) cell and macrophage populations found during early pregnancy are distinctive in their cell surface markers and functions compared to their peripheral counterparts. 1,2 Understanding the activity and control of these immune cell types will shed light on this immunological paradox and possibly inform the pathophysiology of complications of pregnancy.During the past decade, numerous studies have characterized critical roles for the peptide hormone adrenomedullin (Adm gene; AM protein) in the establishment and maintenance of a healthy pregnancy. Here, we discuss the effects of AM on implantation and placentation, concentrating on the control of the uNK cell population and its subsequent involvement in the process of spiral artery remodeling-a necessary process for the maternal vascular adaptation to pregnancy. Importantly, studies addressing the link between

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Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct

Cited by 25 publications

References 27 publications

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Oviduct: roles in fertilization and early embryo development

Adrenomedullin and endocrine control of immune cells during pregnancy

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