We have used nanoscale zero-valent iron particles to remove Acid Green 25 (AG-25) dye from aqueous solution and have studied the effects of important variables, such as dye concentration, catalyst amount, pH and time, on the dye removal process, optimized by the Taguchi approach. Sixteen experiments were required to study the effect of all four parameters on removal of the dye. Each experiment was repeated three times to calculate the signal/ noise (S/N) ratio. Based on the S/N ratio, optimum values of 4, 0.6 g, 120 s, 20 mg L -1 were obtained for pH, catalyst amount, time and dye concentration, respectively. At the optimized condition, the removal percentages of AG-25 dye was found to be 96.82%.