Adsorption behaviours and transfer simulation of levofloxacin in silty clay

Wei, Mengxian; Lv, Dunyu; Cao, Lianhai; Zhou, Kai; Jiang, Kai

doi:10.1007/s11356-021-13955-x

Cited by 15 publications

(7 citation statements)

References 36 publications

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“…WWTPs-treated sewage has been discharged into surface water, and activated sludge in WWTPs has been reused as biological fertilizer, which has caused antimicrobials to enter the natural water cycle and to spread to soil [ 48 ]. Antimicrobials have been observed in wastewater, surface water, drinking water, groundwater, and soil to some extent [ 49 , 50 , 51 , 52 , 53 ], and the concentration is generally between ng/L and mg/L levels [ 54 ].…”

Section: The Usage and Fate Of Antimicrobials In The Environmentmentioning

confidence: 99%

Antimicrobial and the Resistances in the Environment: Ecological and Health Risks, Influencing Factors, and Mitigation Strategies

Wang

Weng

Luo

et al. 2023

Toxics

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Antimicrobial contamination and antimicrobial resistance have become global environmental and health problems. A large number of antimicrobials are used in medical and animal husbandry, leading to the continuous release of residual antimicrobials into the environment. It not only causes ecological harm, but also promotes the occurrence and spread of antimicrobial resistance. The role of environmental factors in antimicrobial contamination and the spread of antimicrobial resistance is often overlooked. There are a large number of antimicrobial-resistant bacteria and antimicrobial resistance genes in human beings, which increases the likelihood that pathogenic bacteria acquire resistance, and also adds opportunities for human contact with antimicrobial-resistant pathogens. In this paper, we review the fate of antimicrobials and antimicrobial resistance in the environment, including the occurrence, spread, and impact on ecological and human health. More importantly, this review emphasizes a number of environmental factors that can exacerbate antimicrobial contamination and the spread of antimicrobial resistance. In the future, the timely removal of antimicrobials and antimicrobial resistance genes in the environment will be more effective in alleviating antimicrobial contamination and antimicrobial resistance.

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Section: The Usage and Fate Of Antimicrobials In The Environmentmentioning

confidence: 99%

Antimicrobial and the Resistances in the Environment: Ecological and Health Risks, Influencing Factors, and Mitigation Strategies

Wang

Weng

Luo

et al. 2023

Toxics

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“…In addition, oral bioavailabilities of chelating drugs were compared between EDTA-treated and control rabbits. As chelating drugs, antibiotics such as levofloxacin (LFX), ciprofloxacin (CFX) and tetracycline (TC) were used, because these antibiotics are known to interact with cationic metals and cationic metal-containing solid materials by chelation and adsorption [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Recently, it was reported that among patients who received oral fluoroquinolones or tetracyclines, 47 patients (26.6%) ingested antibiotics with divalent or trivalent cation-containing compounds, in which ciprofloxacin (61.7%) was the most used antibiotic, followed by moxifloxacin (25.5%) and doxycycline (12.8%) [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline

et al. 2023

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Laboratory rabbits are fed foods rich with cationic metals, and while fasting cannot empty gastric contents because of their coprophagic habits. This implies that, in rabbits, the oral bioavailability of chelating drugs could be modulated by the slow gastric emptying rates and the interaction (chelation, adsorption) with gastric metals. In the present study, we tried to develop a rabbit model with low amounts of cationic metals in the stomach for preclinical oral bioavailability studies of chelating drugs. The elimination of gastric metals was achieved by preventing food intake and coprophagy and administering a low concentration of EDTA 2Na solution one day before experiments. Control rabbits were fasted but coprophagy was not prevented. The efficacy of rabbits treated with EDTA 2Na was evaluated by comparing the gastric contents, gastric metal contents and gastric pH between EDTA-treated and control rabbits. The treatment with more than 10 mL of 1 mg/mL EDTA 2Na solution decreased the amounts of gastric contents, cationic metals and gastric pH, without causing mucosal damage. The absolute oral bioavailabilities (mean values) of levofloxacin (LFX), ciprofloxacin (CFX) and tetracycline hydrochloride (TC), chelating antibiotics, were significantly higher in EDTA-treated rabbits than those in control rabbits as follows: 119.0 vs. 87.2%, 9.37 vs. 13.7%, and 4.90 vs. 2.59%, respectively. The oral bioavailabilities of these drugs were significantly decreased when Al(OH)3 was administered concomitantly in both control and EDTA-treated rabbits. In contrast, the absolute oral bioavailabilities of ethoxycarbonyl 1-ethyl hemiacetal ester (EHE) prodrugs of LFX and CFX (LFX-EHE, CFX-EHE), which are non-chelating prodrugs at least in in vitro condition, were comparable between control and EDTA-treated rabbits irrespective of the presence of Al(OH)3, although some variation was observed among rabbits. The oral bioavailabilities of LFX and CFX from their EHE prodrugs were comparable with LFX and CFX alone, respectively, even in the presence of Al(OH)3. In conclusion, LFX, CFX and TC exhibited higher oral bioavailabilities in EDTA-treated rabbits than in control rabbits, indicating that the oral bioavailabilities of these chelating drugs are reduced in untreated rabbits. In conclusion, EDTA-treated rabbits were found to exhibit low gastric contents including metals and low gastric pH, without causing mucosal damage. Ester prodrug of CFX was effective in preventing chelate formation with Al(OH)3 in vitro and in vivo, as well as in the case of ester prodrugs of LFX. EDTA-treated rabbits are expected to provide great advantages in preclinical oral bioavailability studies of various drugs and dosage formulations. However, a marked interspecies difference was still observed in the oral bioavailability of CFX and TC between EDTA-treated rabbits and humans, possibly due to the contribution of adsorptive interaction in rabbits. Further study is necessary to seek out the usefulness of the EDTA-treated rabbit with less gastric contents and metals as an experimental animal.

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“…From 2000 to 2015, the worldwide consumption of antibiotics in humans and in veterinary medicine increased by almost 65% [1,2], due to the increase in the world population, and to the higher demand for protein, which intensified animal production, requiring a higher use of antibiotics [3,4]. Among these drugs, cephalosporins, belonging to the group of beta-lactams, are widely used in the treatment of bacterial infections, as they have good tolerance and few side effects [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Cela-Dablanca et al [22] studied the retention of CFX in various soils, finding adsorption values between 40.8% and 99.6% (between 54.39 and 125 µmol kg −1 ) in those devoted to agricultural production, and between 74.6% and 93.5% (between 109.9 and 116.71 µmol kg −1 ) in forest soils. However, taking into account that the presence of antibiotics both in soils and other environmental compartments is considered a matter of real concern, growing research is focusing on the design of systems and procedures to remove/retain these molecules, with special emphasis on wastewater, which is often used as irrigation waters [2,23], and also in soils [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Different Waste and By-Products from Forest and Food Industries in the Removal/Retention of the Antibiotic Cefuroxime

et al. 2021

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Environmental pollution due to antibiotics is a serious problem. In this work, the adsorption and desorption of the antibiotic cefuroxime (CFX) were studied in four by-products/residues from the forestry and food industries. For this, batch-type experiments were carried out, adding increasing concentrations of CFX (from 0 to 50 µmol L−1) to 0.5 g of adsorbent. The materials with a pH higher than 9 (mussel shell and wood ash) were those that presented the highest adsorption percentages, from 71.2% (23.1 µmol kg−1) to 98.6% (928.0 µmol kg−1). For the rest of the adsorbents, the adsorption was also around 100% when the lowest concentrations of CFX were added, but the percentage dropped sharply when the highest dose of the antibiotic was incorporated. Adsorption data fitted well to the Langmuir and Freundlich models, with R2 greater than 0.9. Regarding desorption, the materials that presented the lowest values when the highest concentration of CFX was added were wood ash (0%) and mussel shell (2.1%), while pine bark and eucalyptus leaves presented the highest desorption (26.6% and 28.6%, respectively). Therefore, wood ash and mussel shell could be considered adsorbents with a high potential to be used in problems of environmental contamination by CFX.

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Adsorption behaviours and transfer simulation of levofloxacin in silty clay

Cited by 15 publications

References 36 publications

Antimicrobial and the Resistances in the Environment: Ecological and Health Risks, Influencing Factors, and Mitigation Strategies

Antimicrobial and the Resistances in the Environment: Ecological and Health Risks, Influencing Factors, and Mitigation Strategies

Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline

Efficacy of Different Waste and By-Products from Forest and Food Industries in the Removal/Retention of the Antibiotic Cefuroxime

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