Adsorptive Stripping Voltammetric Determination of Bupropion in Pharmaceuticals

doi:10.7598/cst2017.1371

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…Although the pp-AN/SPCE sensor is less sensitive than mercury electrode [ 14 ], it is worth noting that these electrodes have already been withdrawn from the use due to the toxicity of mercury vapor. The GCE [ 15 ] shows similar analytical parameters in terms of BUP determination as the mass-produced pp-AN/SPCE, but it is expensive and cannot be adopted in complex measurement systems (e.g., flow-through) offered by Methrom. Admittedly, the use of EIS technique allows to obtain very low LOD [ 16 ]; however, it also requires expensive equipment and the ability to use specialized software as well as many years of experience in interpreting EIS spectra.…”

Section: Resultsmentioning

confidence: 99%

“…In other works, the recorded signal is related to the reduction of the carbonyl group present in the BUP molecule, which corresponds to the cathodic peak at potential ca. −1.2 V [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…Mainly chromatographic and spectrometric methods have been developed for BUP determination in pharmaceutical and biological samples, i.e., high-performance liquid chromatography with a spectrofluorometric detection [ 10 ], liquid chromatography coupled with tandem mass spectrometry [ 11 ], or capillary electrophoresis combined with phosphorescence detection [ 12 ]. In the case of electroanalytical methods, only a few examples of electrochemical sensors enabling the determination of BUP have been reported so far, including ion-selective PCV membrane electrodes [ 13 ], dropping mercury electrode [ 14 ], bulk glassy carbon electrode [ 15 ], and a carbon screen-printed electrode modified with molecularly imprinted polymer, gold nanoparticles, and graphene oxide as an electrochemical impedance spectroscopy sensor [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical sensing platform based on screen-printed carbon electrode modified with plasma polymerized acrylonitrile nanofilms for determination of bupropion

Madej,

Trzcińska,

Lipińska

et al. 2023

Microchim Acta

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A original electrochemical sensing platform, based on screen-printed electrodes modification with plasma polymerized acrylonitrile (pp-AN) nanofilms is proposed. For that purpose, plasma-enhanced chemical vapor deposition (PECVD) process was conducted in a parallel plate (13.56 MHz) plasma reactor for 2 min with discharge power of 10 W. The surface topography and electrochemical properties of prepared sensors were investigated by X-ray photoelectron spectroscopy, scanning electron microscopy, energy dispersion spectroscopy, electrochemical impedance spectroscopy, and cyclic voltammetry. The electrochemical characteristics of pp-AN/SPCE and pp-AN/SPAuE sensors was investigated for model redox pair [Fe(CN)6]4−/3−. Conducted research confirmed the excellent chemical stability, durability, wide potential window, high signal-to-noise (S/N) ratio, and, most importantly, the ability to standardize the sensors. The pp-AN/SPCE sensor was applied to the determination of bupropion, an antidepressant drug whose intake has increased dramatically during the COVID-19 pandemic. The voltammetric response of pp-AN/SPCE for BUP was linear in two concentration ranges of 0.63–10.0 and 10.0–50.0 μmol L−1, with a detection limit of 0.21 μmol L−1. Satisfactory recoveries (96.2–102%) and good precision (RSD below 4.1%) obtained for environmental and biological samples confirmed the usefulness of the sensor for the analysis of various kinds of samples. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

“…In other works, the recorded signal is related to the reduction of the carbonyl group present in the BUP molecule, which corresponds to the cathodic peak at potential ca. −1.2 V [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical sensing platform based on screen-printed carbon electrode modified with plasma polymerized acrylonitrile nanofilms for determination of bupropion

Madej,

Trzcińska,

Lipińska

et al. 2023

Microchim Acta

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Eco-friendly bupropion detection sensor with co-formulated dextromethorphan in AUVELITY tablet and spiked plasma

Algmaal,

Mahmoud,

Boltia

et al. 2024

Sci Rep

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Molecularly Imprinted Polymers (MIPs) are synthetic materials designed to selectively recognize and bind to specific target molecules. The process of determining Bupropion (BUP) using MIPs involves preparing the MIP, extracting the target molecule, and conducting subsequent analysis. A bio-inspired MIP-based electrochemical sensor was developed to detect BUP, utilizing the specific binding of MIPs to Bupropion molecules, enabling precise and sensitive detection. The combination of molecular imprinting and electrochemistry in this approach allows for the development of a highly reliable and effective sensor specifically designed for BUP detection. In this method, copolymerization conditions were carefully optimized to ensure selectivity and sensitivity in detecting BUP. Different monomers, including o-phenylenediamine, 4-aminophenol, L-dopa, and 1,4-phenylenediamine, were explored, with the best interaction observed for L-dopa and 1,4-phenylenediamine. Consequently, their copolymer was implemented to create selective MIPs through a straightforward electropolymerization process on a disposable pencil graphite electrode (PGE) substrate for BUP detection. The functionality of the copolymer of L-dopa and 1,4-phenylenediamine as an electroactive copolymer in preparing electro-polymerized MIP films was investigated for the first time. This was demonstrated by constructing a novel electrochemical sensor for the selective recognition of BUP in different matrices. The interactions between L-dopa and 1,4-phenylenediamine, used as functional monomers, and the template were studied experimentally using UV spectroscopy. BUP was used as the template, and the copolymer was electrografted onto PGE. The constructed sensor was characterized using cyclic voltammetry (CV), and BUP binding to the MIP cavities was measured indirectly with differential pulse voltammetry (DPV) using a ferrocyanide/ferricyanide redox probe. A linear and repeatable response was displayed by the sensor across a range of 1.0 × 10⁻13 M to 1.0 × 10⁻11 M of BUP, with a limit of detection of 3.18 × 10⁻14 M. The sensor demonstrated robust selectivity for BUP over interfering drugs, such as dextromethorphan, in pharmaceutical dosage forms and spiked human plasma. The environmental impact of the proposed approach was evaluated using green analytical chemistry principles, including the Green Analytical Procedure Index (GAPI) and the Analytical GREEnness (AGREE) metric.

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Adsorptive Stripping Voltammetric Determination of Bupropion in Pharmaceuticals

Cited by 2 publications

References 26 publications

Electrochemical sensing platform based on screen-printed carbon electrode modified with plasma polymerized acrylonitrile nanofilms for determination of bupropion

Electrochemical sensing platform based on screen-printed carbon electrode modified with plasma polymerized acrylonitrile nanofilms for determination of bupropion

Eco-friendly bupropion detection sensor with co-formulated dextromethorphan in AUVELITY tablet and spiked plasma

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