Adsorptive stripping voltammetric methods for determination of aripiprazole

Aşangil, Derya; Kılıç, Esma

doi:10.1016/j.jpha.2012.01.009

Cited by 25 publications

(8 citation statements)

References 17 publications

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“…A look at the recently published literature shows that reference electrodes with nanoporous glass plugs are not only used frequently for measurements with aqueous samples but are also very popular for measurements in organic solvents such as acetonitrile, 34 propylenecarbonate, 35 methanol, 36 dichloromethane, 37 and ionic liquids. 38 This prompted us to investigate the performance of reference electrodes with nanoporous glass plugs also with acetonitrile as a representative organic solvent.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Reference Electrodes with Salt Bridges Contained in Nanoporous Glass: An Underappreciated Source of Error

Mousavi

Bühlmann

2013

Anal. Chem.

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In electroanalytical measurements, nanoporous glass plugs are widely used to contain the electrolyte solution that forms a salt bridge between the sample and the reference electrode. Even though reference electrodes with plugs made of nanoporous glass (such as Vycor or CoralPor glass) are commercially available and are frequently used, the limits of their use have not been explored thoroughly. It is shown here that at ionic strengths lower than 100 mM, the half-cell potentials of reference electrodes with nanoporous glass plugs are not sample independent, as it would be desirable, but they depend on the ionic sample composition. Sample dependent shifts of more than 50 mV in the half cell potential were encountered. Reference potentials were found to be affected in aqueous solutions by HCl, NaCl, KCl, and CaCl2 and in acetonitrile by CF3COOH and the supporting electrolyte tetrabutylammonium perchlorate. These observations cannot be explained by the liquid junction potential between two mutually miscible electrolyte solutions, as commonly described with the Henderson equation. Instead, they result from the surface charge density on the glass surface and the resulting electrostatic screening of ion transfer into the glass pores when the latter have dimensions comparable to or smaller than the Debye length. Users of reference electrodes with nanoporous glass plugs need to be aware of these limitations to avoid substantial measurement errors.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Reference Electrodes with Salt Bridges Contained in Nanoporous Glass: An Underappreciated Source of Error

Mousavi

Bühlmann

2013

Anal. Chem.

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“…A wide variety of methods are available for the determination of ARP in pharmaceutical preparations and biological samples, such as chromatography, [6][7][8][9][10][11][12][13][14][15][16][17] mass spectrometry, [18][19][20][21][22][23][24][25][26][27] electrophoresis, 28,29 spectrophotometry [30][31][32][33][34][35][36] and electrochemistry. 37,38 Chemiluminescence (CL) is an attractive means of detection because it presents low detection limits, a wide linear working range and uses relatively simple instrumentation. For these reasons, CL has received much attention in various elds, especially in combination with separation methods, for analysis of drugs in biological samples.…”

Section: Introductionmentioning

confidence: 99%

Sensitive determination of aripiprazole using chemiluminescence reaction of tris(1,10-phenanthroline)ruthenium(ii) with acidic Ce(iv)

Mokhtari

2014

Anal. Methods

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Aripiprazole (ARP) is an atypical antipsychotic medication used for the treatment of schizophrenia and schizoaffective disorders. In this study, a new method using the chemiluminescence (CL) of tris(1,10-phenanthroline)-ruthenium(II), Ru(phen) 3 2+ , was developed for the rapid and sensitive determination of ARP in pharmaceuticals and human plasma. The method is based on the fact that the weak chemiluminescence produced in the reaction of Ru(phen) 3 2+ and acidic Ce(IV) is enhanced in the presence of ARP. Under the selected experimental conditions, calibration curves were linear from 1.8 to 18.0 ng mL À1 (r 2 ¼ 0.9951) and from 18 to 35 900 ng mL À1 (r 2 ¼ 0.9987). The limit of detection (LOD) was 0.9 ng mL À1 (S/N ¼ 3). In the method proposed, the LOD was about 100 times lower than the therapeutic concentration of ARP. The percent relative standard deviations (%RSDs) for 11 repeated measurements of 180 and 720 ng mL À1 of ARP were 4.5 and 5.2%, respectively. The sampling rate for analysis was 70 samples per hour. The proposed method was successfully applied to the assay of commercial tablets containing the drug, and the results were in accordance with those obtained with the reference method. The method was further applied to the determination of the drug in plasma samples. The possible CL reaction mechanism was also discussed briefly.

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“…The results showed that by increasing the v, the E p shifted to more negative potentials and accompanied with the increase of the I p . The increase of I p indicated an adsorption phenomenon of the RB5 dye at the surface of the mercury electrode [28,29]. A linear relationship was observed between log I p against log v with a slope of 0.5282 (R 2 = 0.9982, n = 6), as shown in Figure 3.…”

Section: Results and Discussion Electrochemical Behaviour Of The Rb5 Dyementioning

confidence: 80%

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

Yaacob¹

2016

MJAS

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A cyclic voltammetry (CV) and differential pulse cathodic stripping voltammetry (DPCSV) studies of RB5 in Britton-Robinson buffer (BRB) at a hanging mercury dropping electrode (HMDE) are described. CV was carried out by cathodic and anodic potential scan over the range of +200 mV to -800 mV with no accumulation time and three well-defined pH-dependent cathodic peaks were observed. The effects of different scan rates, pH of BRB, repetitive cycle and increasing concentrations on the peak height and peak potential of the analyte were studied. The results showed that RB5 dye was adsorbed and irreversibly reduced at the mercury electrode, mainly under diffusion controlled in the optimum pH 4.0 of BRB. By using DPCSV, pH of BRB and various instrumental parameters such as scan rate, accumulation time, accumulation potential and pulse amplitude that may affect the peak height of RB5 were investigated and optimized for RB5 determination. Under the optimized parameters, the peak height was found to be linear with RB5 concentration in the range from 2.5 x 10 -7 mol L -1 to 2.0 x 10 -6 mol L -1 . A detection limit (3SD/m) of 1.3 x 10 -8 mol L -1 was achieved. The precision of the developed method in terms of RSD was 0.55% for intra-day measurement and 0.55%, 0.24% and 0.40%, for inter-day measurements, respectively. The developed method was successfully applied in the determination of RB5 in batik wastewaters with the mean recovery of 83.97 ± 4.78% to 97.93 ± 5.45% (0.5 x 10 -6 mol L -1 ), 95.91 ± 2.68% to 103.49 ± 1.32% (1.0 x 10 -6 mol L -1 ) and 99.17 ± 0.75% to 105.12 ± 0.28% (2.0 x 10 -6 mol L -1 ). The developed method is considered sensitive, precise, accurate, rugged, robust, fast and low cost for routine analysis of RB5 dye in batik wastewaters over the UV-VIS spectrometry method.Keywords: Reactive Black 5, differential pulse cathodic stripping, Britton-Robinson buffer, hanging mercury dropping electrode, batik wastewater samples Abstrak Kajian voltammetri berkitar (CV) dan voltammetri perlucutan denyut kebezaan (DPCSV) terhadap pewarna RB5 dalam larutan penimbal Britton-Robinson (BRB) menggunakan elektrod jatuhan raksa tergantung (HMDE) dihuraikan. CV dijalankan dengan mengimbas potential kathodik dan anodik dari +200 mV ke -800 mV tanpa masa pengumpulan dan tiga puncak diperhatikan selepas imbasan. Kesan perbezaan kadar imbasan, pH BRB, imbasan berkitar yang berulang dan peningkatan kepekatan RB5 ke atas ketinggian dan nilai keupayaan puncak dikaji. RB5 yang dijerap dan diturunkan secara tidak berbalik pada permukaan elektrod merkuri adalah dibawah kawalan difusi pada pH BRB yang optimum iaitu 4.0. Dengan menggunakan DPCSV, pH BRB dan parameter-parameter peralatan yang memberi kesan kepada ketinggian puncak seperti kadar imbasan, masa pengumpulan, keupayaan pengumpulan dan amplitud denyut telah dioptimumkan untuk analisis RB5. Ketinggian puncak berkadar terus dengan kepekatan RB5 dalam julat dari 2.5 x 10 -7 mol L -1 hingga 2.0 x 10 -6 mol L -1 . Had pengesanan adalah 1.3 x 10 -8 mol L -1 . Ketepatan (RSD...

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Adsorptive stripping voltammetric methods for determination of aripiprazole

Cited by 25 publications

References 17 publications

Reference Electrodes with Salt Bridges Contained in Nanoporous Glass: An Underappreciated Source of Error

Reference Electrodes with Salt Bridges Contained in Nanoporous Glass: An Underappreciated Source of Error

Sensitive determination of aripiprazole using chemiluminescence reaction of tris(1,10-phenanthroline)ruthenium(ii) with acidic Ce(iv)

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

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