Adult pityriasis lichenoides‐like mycosis fungoides: a clinical variant of mycosis fungoides

Abstract

In patients with clinical features of longstanding PL and histological findings consistent with MF, differential diagnosis must include PL, LyP, and papular MF. As some forms of PL evolve towards MF and PL-like forms of MF, these patients should undergo regular follow-up and repeated biopsies in order to discard diagnoses of atypical forms of MF.

Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy

“…PL and PL-like MF have been described as having similar clinical and histological findings. Three of four patients were initially diagnosed with PL based on their clinical and histological associations; however, additional histological tests confirmed that they had PL-like MF 6 . The important clinical differentiation between PL and PL-like MF is that PL spontaneously heals within several months.…”

“…It is crucial that PL-like lesions are differentiated from those of PL, papular MF, and lymphomatoid papulosis (LyP) using histology. de Unamuno Bustos et al 6 reported that PL, PL-like MF, papular MF, and LyP all produce papular lesions with histological MF patterns ( Table 4 ). PL and PL-like MF have been described as having similar clinical and histological findings.…”

“…Therefore, the distinction between LyP and PL, especially pityriasis lichenoides et varioliformis acuta (PLEVA), can be particularly difficult. In the proper clinical setting, the presence of large atypical CD30 + cells favors the diagnosis of LyP 6 8 .…”

“…Wang et al 19 reported one case of complete response using topical corticosteroids. de Unamuno Bustos et al 6 reported three cases of combination therapy that included PUVA and one case of PUVA therapy alone. They found that there was a partial response in the three cases of combination therapy, and a complete response in the PUVA-only case.…”

Development of Pityriasis Lichenoides in a Pediatric Patient with Mycosis Fungoides

“…Bu lezyonlar MF'den oldukça farklı bir seyir gösterdi. Hastamızdaki iki nadir hastalık birlikteliğinin rastlantısal bir durum mu yoksa anlamlı mı olduğunu araştırdığımızda literatürde az sayıda olguda bu iki hastalığın bir arada olduğunu; ancak bunların homojen bir grup oluşturmadığını belirledik(2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Tüm bu olguları ve bizim hastamızı bir arada değerlendirdiğimizde aradaki ilişkinin dört grup şeklinde sınıflandırılabileceği görüşündeyiz.…”