Adult Primary Spinal Epidural Extraosseous Ewing’s Sarcoma: A Case Report and Review of the Literature

Bustoros, Mark; Thomas, Cheddhi; Frenster, Joshua D.; Modrek, Aram S.; Bayın, N. Sumru; Snuderl, Matija; Rosen, Gerald; Schiff, Peter B.; Placantonakis, Dimitris G.

doi:10.1155/2016/1217428

Cited by 12 publications

(27 citation statements)

References 40 publications

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“…Distant metastases occurred in nearly 40% of the cases. Lung, spine, and brain were the most frequent sites of metastasis [12][13][14][15] . Neurological deficit is most important determinant for deciding treatment of disease.…”

Section: Discussionmentioning

confidence: 99%

“…There is also evidence that neoadjuvant therapy may be of limited use in spinal epidural EES. Patient treated with chemoradiotherapy after surgery have better 1 year survival than patient treated with surgery, chemotherapy and radiotherapy alone [15][16][17][18] . In our patient chemo-radiotherapy was not found to be very effective in reducing tumor mass.…”

Section: Discussionmentioning

confidence: 99%

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An undiagnosed chronic back pain may come out with severe morbidity in young patient, needs to be evaluated adequately: A case report and review of literature

Pathak¹,

Sharma²,

Mohan³

et al. 2017

Int. J. Orthop. Sci.

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Introduction: there are various possible etiology for chronic back pain and malignancy is one of them. Extraskeletal Ewing's Sarcoma usually involves sacrum while dorsolumbar junction involvement is uncommon. We are reporting a case of Extraskeletal Ewing's Sarcoma with rare presentation related to the age, site of lesion and unusual extension. Case presentation: 35 year old male presented to casualty with urinary retention and paraplegia of sudden onset with history of chronic back pain of 6 months. We investigated him and diagnosed extra skeletal Ewing's Sarcoma of paravertebral origin along D12-L1 spine with intaspinal intadural extension. Patient was given palliative chemo-radiotherapy. Conclusion: Chronic back pain of unknown etiology should be evaluated properly and while making diagnosis possible malignant etiology should be kept in mind even in young patient to prevent undue morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An undiagnosed chronic back pain may come out with severe morbidity in young patient, needs to be evaluated adequately: A case report and review of literature

Pathak¹,

Sharma²,

Mohan³

et al. 2017

Int. J. Orthop. Sci.

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“…Ewing's sarcoma is nowadays a well-known malignant entity, classified as a primitive neuroectodermal tumor (PNET) [1]. While the most common form, the osseous Ewing's sarcoma (OES), arises in 85% from the diaphysis of long bones of the lower extremities primarily in children and adolescents in the first two decades of life, the quite rare extraskeletal or extraosseous Ewing's sarcoma (EES) can develop in around 15% of cases in soft tissues outside the bones, with cases reported in the esophagus, the larynx, the chest wall, the kidney, the head and neck region, the pelvis, the peritoneum and the paravertebral space [2][3][4]. It has also been described in the spinal epidural space, with a slight predilection for the thoracic spine [5,6].…”

Section: Introductionmentioning

confidence: 99%

A Primary Dumbbell-Shaped Cervical Extraskeletal Ewing’s Sarcoma in an Adult: A Case Report and Literature Review

Bteich¹,

Moussa²

2020

SCR

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Dumbbell spinal tumors get their hourglass or dumbbell shape from being constricted in the middle, with one part inside the spinal canal and the other extending outside of it. This is the case of a 37-year-old female who presented to the clinic with a left cervicobrachialgia and acroparesthesia. While radiographic imaging initially reported a well-defined dumbbell-shaped C7-T1 foraminal tumor consistent with a neurinoma, the pathology report obtained after surgical intervention came back positive for Ewing’s sarcoma, with no other locations of the tumor. The diagnosis was unexpected given the shape of the tissue and the rarity of the extraskeletal form of Ewing’s sarcoma (EES). Only 4 previous cases to date have identified a primary cervical dumbbell-shaped extraskeletal Ewing’s sarcoma in adults.

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“…5 However, few cases of extraosseous Ewing sarcoma originating in the epidural space, as in our case, have been reported. [6][7][8] It is important to characterize epidural extraosseous Ewing sarcoma tumors to determine the prognostic significance and treatment implications.…”

Section: Introductionmentioning

confidence: 99%

Lower Extremity Weakness in an Adolescent Female – A Rare Presentation of Ewing Sarcoma

Addesso

Koenig

Huq

2018

TOJ

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Background: Ewing sarcoma, a rare cause of cord compression, is predominantly of osseous origin but can also originate in soft tissues. Soft-tissue manifestations account for <15% of all Ewing sarcoma tumors, and even fewer cases of Ewing sarcoma originating in the epidural space have been documented. Case Report: A 19-year-old female presented to the emergency department for worsening low-back pain during the previous 6 months and numbness and weakness in her legs during the prior 2 weeks. Magnetic resonance imaging revealed an epidural mass at the L4-L5 level. Intravenous steroids were started for a presumed diagnosis of lymphoma. Orthopedic surgery consultants deferred computed tomography-guided biopsy of the mass out of concern for tumor seeding. Compression symptoms worsened to include foot drop and saddle anesthesia, prompting urgent radiation therapy. After the patient showed poor response to appropriate treatment for lymphoma, other malignant and infectious causes were considered. Biopsy was performed on day 3 of the patient's hospital stay, and by day 7, preliminary cytology results revealed Ewing sarcoma. Subsequent laminectomy and tumor resection produced immediate relief of pain, along with a gradual return of strength and sensation. The mass was found to be of soft-tissue origin and was classified as an extraosseous Ewing sarcoma. The patient was referred to a pediatric oncologist to complete the appropriate chemotherapy after diagnosis. Conclusion: This case demonstrates how an uncommon manifestation of a rare disease can mimic a classic presentation of cord compression. Our aim is to bring awareness to this disease and to emphasize the importance of timely biopsy of any mass.

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Adult Primary Spinal Epidural Extraosseous Ewing’s Sarcoma: A Case Report and Review of the Literature

Cited by 12 publications

References 40 publications

An undiagnosed chronic back pain may come out with severe morbidity in young patient, needs to be evaluated adequately: A case report and review of literature

An undiagnosed chronic back pain may come out with severe morbidity in young patient, needs to be evaluated adequately: A case report and review of literature

A Primary Dumbbell-Shaped Cervical Extraskeletal Ewing’s Sarcoma in an Adult: A Case Report and Literature Review

Lower Extremity Weakness in an Adolescent Female – A Rare Presentation of Ewing Sarcoma

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