Adulthood bisphenol A exposure induces anxiety in male mice via downregulation of alpha-1D adrenergic receptor in paraventricular thalamus

Ji, Ran; Cui, Mengqiao; Zhou, Dongyu; Pan, Xiaoyuan; Xie, Y.; Wu, Xiaopan; Liang, Xueying; Zhang, Hongxing; Song, Weiyi

doi:10.1016/j.ecoenv.2023.115205

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…The contrast between the level of exposure and the toxic effects further highlighted the susceptibility of males to TCS. Notably, in terms of neurotoxicity, several environmental contaminants, such as polychlorinated biphenyls and bisphenol A, have been found to exert greater toxicity in males than females. These sex-specific effects are presumed to be attributed to the inherent substantial differences in sex hormonal levels and detoxifying capacities between males and females .…”

Section: Discussionmentioning

confidence: 99%

Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Li,

Xian,

Ren

et al. 2024

Environ. Health

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Triclosan (TCS) has garnered significant attention due to its widespread use and associated endocrine-disrupting effects. However, its impact on the neuroendocrine system and underlying mechanisms remain poorly understood. Here, we established correlations between TCS exposure and serum sex hormone levels in participants of the National Health and Nutrition Examination Survey (NHANES). Additionally, we investigated TCS's influence on the neuroendocrine system using adult zebrafish exposed to environmentally relevant concentrations of TCS (0.361−48.2 μg/L) for 21 days. Assessment of reproductive and neurotoxicity included histopathological examination and behavioral tests. Transcriptomics, proteomics analyses, and biochemical detection were employed to elucidate mechanisms underlying TCS-induced neuroendocrine disruption. Significant correlations were found between TCS exposure and estradiol, testosterone, and sex hormone-binding globulin levels in NHANES participants. In addition, TCS exposure inhibited ovary development and spermatogenesis in zebrafish. Transcriptomics and proteomics analysis revealed gender-specific key signaling and metabolism-related pathways implicated in TCS-induced reproductive toxicity. Moreover, TCS exposure induced nervous system impairment, as evidenced by histological changes and altered motor behavior, possibly associated with oxidative damage. Correlation analysis further highlighted the potential connection between endocrine system disruption and nervous system impairment following TCS exposure. Overall, this study provided evidence supporting TCS-induced endocrine disruption and offered insights into its underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Li,

Xian,

Ren

et al. 2024

Environ. Health

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Perinatal exposure to bisphenol A or S: Effects on anxiety-related behaviors and serotonergic system

Bonaldo,

Casile,

Ostuni

et al. 2024

Chemosphere

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Ascorbic acid and gallic acid mitigate behavioural deficits and loss of cerebellar myelin induced by Bisphenol-A in Wistar rats

Adigun,

Ehinmowo,

Folarin

et al. 2024

Preprint

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BackgroundBisphenol-A (BPA) is a chemical component of plastics, polycarbonates, and epoxy resins making it an environmentally ubiquitous chemical. Its toxicity has been linked to several disorders including neurological disorders. Gallic acid (GA) and Ascorbic acid (AA) are both antioxidants that have been reported to have neuroprotective effects. We therefore investigated the neuroprotective effects of GA and AA on BPA-induced neurotoxicity.Forty-eight (48) Wistar rats were grouped into Control, BPA, BPA+AA, BPA+GA, AA, and GA groups with eight rats in each group. All treatments were administered via oral gavage for 21 days. Behavioral experiments were conducted to assess forelimb strength (hanging wire test), anxiety (open field and elevated plus maze tests), depression (forced swim test), and spatial memory (Morris water maze). Rats were perfused and brain samples were collected for Luxol fast blue staining. Sera were collected to evaluate the levels of inflammatory cytokines via Enzyme-Linked Immunosorbent Assay.ResultsThere was no significant difference in hanging latency between all the groups. There were also no significant changes in the open field test but the elevated plus maze showed an increase in time spent in closed arms in the BPA group indicative of anxiety. GA and AA reduced the duration of immobility that was elevated in the BPA group which suggests they have antidepressant-like effects. Additionally, we observed disruption in the Purkinje cell layer of the cerebellum in the BPA-alone group.ConclusionBPA seems to cause anxiety and depressive-like effects which are ameliorated by the gallic acid and ascorbic acid.

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Adulthood bisphenol A exposure induces anxiety in male mice via downregulation of alpha-1D adrenergic receptor in paraventricular thalamus

Cited by 3 publications

References 45 publications

Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Perinatal exposure to bisphenol A or S: Effects on anxiety-related behaviors and serotonergic system

Ascorbic acid and gallic acid mitigate behavioural deficits and loss of cerebellar myelin induced by Bisphenol-A in Wistar rats

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