2012
DOI: 10.1007/s00125-012-2576-3
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ADVANCE and glycaemia thresholds: a need to clarify the statistical approach. Reply to Currie CJ [letter]

Abstract: To the Editor: We thank Professor Currie for his interesting interpretation [1] of the complex analyses undertaken to examine the relationship between HbA 1c and outcomes in the ADVANCE trial cohort [2].With respect to the use of time-weighted average HbA 1c levels, we used several different approaches for assessing HbA 1c levels including baseline values and time-dependent covariates. Each gave similar findings to those presented. The averaging method published was required by reviewers and deemed most unders… Show more

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