“…As a result, they are correlated with a worse prognosis while response to chemoradiotherapy has been associated with a decrease in tumor perfusion and BBB permeability. Increased DSC-CBV was found to be predictive of decreased progression free survival [ 20 , 116 , 117 , 118 , 119 , 125 , 126 , 127 ] and decreased OS [ 20 , 71 , 117 , 119 , 122 , 123 , 124 , 125 , 128 , 129 , 130 , 130 , 131 , 132 , 133 , 134 ] in diffuse cerebral gliomas. These parameters can be also used to follow-up on lower grade glioma lesions and to monitor treatment effects [ 122 , 135 , 136 ].…”