Advanced lithium substituted hydroxyapatite nanoparticles for antimicrobial and hemolytic studies

Padmanabhan, Varun Prasath; Narayanan, T.S.N. Sankara; Sagadevan, Suresh; Hoque, Enamul; Ravichandran, K.

doi:10.1039/c9nj03735g

Cited by 37 publications

(25 citation statements)

References 73 publications

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“…First, the XRD results indicate that Li-BCP powders with different lithium contents were successfully prepared. According to previous studies, the main peak of lithium-doped HA show shifts slightly toward right compared to HA (Padmanabhan et al, 2019) and lithium-doped β-TCP rarely changed in the XRD graph (Matsumoto et al, 2010). In this study, the main peak of the β-TCP phase moved toward a lower angle owing to the increase in the crystal space with the addition of lithium content (Matsumoto et al, 2010).…”

Section: Discussionsupporting

confidence: 65%

Lithium doped biphasic calcium phosphate: Structural analysis and osteo/odontogenic potential in vitro

Yoo

Kim

et al. 2022

Front. Bioeng. Biotechnol.

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Biphasic calcium phosphate (BCP) is generally considered a good synthetic bone graft material with osteoinductive potential. Lithium ions are trace elements that play a role in the bone-remodeling process. This study aimed to investigate the effects of lithium ions on the phase, crystal structure, and biological responses of lithium doped BCPs and to identify improvements in their osteogenic properties. Lithium-doped BCP powders with different doping levels (0, 5, 10, and 20 at%) were synthesized via the co-precipitation method. We found that the four types of lithium-doped BCP powders showed different phase compositions of hydroxyapatite and β-tricalcium phosphate. In addition, lithium ions favored entering the β-tricalcium phosphate structure at the Ca (4) sites and calcium vacancy sites [VCa(4)] up to 10 at%. This substitution improves the crystal stabilization by filling the vacancies with Ca2+ and Li+ in all Ca sites. However, when the concentration of Li ions was higher than 10 at%, lithium-induced crystal instability resulted in the burst release of lithium ions, and the osteogenic behavior of human dental pulp stem cells did not improve further. Although lithium ions regulate osteogenic properties, it is important to determine the optimal amount of lithium in BCPs. In this study, the most effective lithium doping level in BCP was approximately 10 at% to improve its biological properties and facilitate medical applications.

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Section: Discussionsupporting

confidence: 65%

Lithium doped biphasic calcium phosphate: Structural analysis and osteo/odontogenic potential in vitro

Yoo

Kim

et al. 2022

Front. Bioeng. Biotechnol.

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“…To date, the antiviral activity of Li in different viruses (including porcine epidemic diarrhea, pseudorabies herpesvirus, Orthoreoviruses, and Coxsackievirus B3 virus) has been proved [ 193 , 194 , 195 , 196 ]. Additionally, its antibacterial activity against Gram-negative bacteria (including Porphyromonas gingivalis , Francisella tularensis , Aggregatibacter actinomycetemcomitans , Klebsiella pneumoniae , Escherichia coli , Burkholderia pseudomallei , and Pseudomonas aeruginosa ) and Gram-positive bacteria (including Streptococcus pneumoniae , Streptococcus mutans , and Staphylococcus aureus ) has been reported [ 197 , 198 , 199 , 200 , 201 , 202 ]. A summary of the biological effects of Li and the relation between these effects and autophagy is presented in Figure 5 .…”

Section: Lithium and Its Biological Effectsmentioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

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Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

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“…Nanotechnology has successfully introduced nanoadsorbents for wastewater treatment, which has emerged as an enormous growing and enthralling area of interest (Förstner and Wittmann 1985). Generally, nanotechnology is related to the creation, processing, characterization and application of materials at the nanoscale (1-100 nm) in diverse areas (Biswas et al 2017(Biswas et al , 2019Mamalis 2007;Stander and Theodore 2011;Padmanabhan et al 2019;Golieskardi et al 2019;Ragurajan et al 2018;Rangari et al 2017Rangari et al , 2019Nuge et al 2020). Nanomaterials own exceptional properties, which are absent in their corresponding bulk materials.…”

Section: Nanoadsorbentsmentioning

confidence: 99%

Nanoadsorbents for wastewater treatment: next generation biotechnological solution

Ali

Hoque²,

Hossain

et al. 2020

Int. J. Environ. Sci. Technol.

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Day by day, the water sources are increasingly being adulterated due to various reasons including the uncontrolled discharge of pollutants from the point and nonpoint sources. Therefore, it is a timely need to develop suitable, inexpensive and efficient treatment techniques for water purification. This review aims at evaluating different water treatment technologies, their basic principles, cost and suitability for pollutants' removal from wastewater. Among various water treatment technologies, adsorption technique appears to be techno-economically more attractive due to its inexpensiveness, universality and environment friendliness. Here, wide varieties of adsorbents (silica gel, activated alumina, clays, limestone, chitosan, activated carbon, zeolite, etc.) and their capacities for pollutant removal are described. The limitations of conventional adsorbent applications for water treatment are also discussed. Recently, nanotechnology has introduced nanoadsorbents, which have drawn additional attention due to their unique properties and are considered to be the viable alternative to conventional adsorbents. The potential applications, separation and regeneration of nanoadsorbents for wastewater treatment are also included in this review. Furthermore, prospects including commercial and health aspects of nanoadsorbents are also added.

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Advanced lithium substituted hydroxyapatite nanoparticles for antimicrobial and hemolytic studies

Abstract: In this study, pure hydroxyapatite (HAP) and lithium substituted hydroxyapatite (Li-HAP) nanoparticles were synthesized by a sonochemical synthesis process and investigated for their antimicrobial and hemolytic activities.

Cited by 37 publications

References 73 publications

Lithium doped biphasic calcium phosphate: Structural analysis and osteo/odontogenic potential in vitro

Lithium doped biphasic calcium phosphate: Structural analysis and osteo/odontogenic potential in vitro

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Nanoadsorbents for wastewater treatment: next generation biotechnological solution

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