Advanced materials based on montmorillonite modified with poly(ethylenimine) and poly(2-methyl-2-oxazoline): Experimental and DFT study

Madejová, Jana; Barlog, Martin; Slaný, Michal; Bashir, Sanam; Scholtzová, Eva; Tunega, Daniel; Jankovič, Ľuboš

doi:10.1016/j.colsurfa.2022.130784

Cited by 8 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Mucoadhesion has been extensively used in drug delivery to enhance the retention time of formulations, employing chitosan, 7 xanthan gum, 8 and weakly cross-linked poly(acrylic acid). 9 Linear poly(ethylenimine) (L-PEI) has been explored for various applications, 10 such as gene delivery, 11−13 water purification, 14 to produce functional inorganic minerals, 15 and in PEI conjugates. 16−18 Due to the presence of cationic secondary amine groups within L-PEI, which can interact with negatively charged mucin, L-PEI has also gained some attention for mucoadhesive applications in nasal 19 and buccal drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…Linear poly(ethylenimine) (L-PEI) has been explored for various applications, such as gene delivery, − water purification, to produce functional inorganic minerals, and in PEI conjugates. − Due to the presence of cationic secondary amine groups within L-PEI, which can interact with negatively charged mucin, L-PEI has also gained some attention for mucoadhesive applications in nasal and buccal drug delivery …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring Mucoadhesive and Toxicological Characteristics Following Modification of Linear Polyethylenimine with Various Anhydrides

Fu,

Moiseev,

Hyder

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

Linear polyethylenimine (L-PEI) has numerous applications, such as in pharmaceutical formulations, gene delivery, and water treatment. However, due to the presence of secondary amine groups, L-PEI shows a relatively high toxicity and low biocompatibility. Here, various organic anhydrides were used to modify L-PEI to reduce its toxicity and enhance its functionality. We selected methacrylic anhydride, crotonic anhydride, maleic anhydride, and succinic anhydride to modify L-PEI. The structure of the resulting derivatives was characterized using 1 H NMR and FTIR spectroscopies, and their behavior in aqueous solutions was studied using turbidimetric and electrophoretic mobility measurements over a broad range of pHs. A fluorescence flow through method determined the mucoadhesive properties of the polymers to the bovine palpebral conjunctiva. Methacrylated L-PEI and crotonylated L-PEI showed strong mucoadhesive properties at pH 7.4, likely due to covalent bonding with mucin thiol groups. In contrast, maleylated and succinylated L-PEI were poorly mucoadhesive as the pH was above their isoelectric point, resulting in electrostatic repulsion between the polymers and mucin. The toxicity of these polymers was evaluated using in vivo assays with planaria and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) cell viability assay in human alveolar epithelial cells. Moreover, the irritancy of polymers was assessed using a slug mucosa irritation assay. The results demonstrated that anhydride modification mitigated the adverse toxicity effects seen for parent L-PEI.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring Mucoadhesive and Toxicological Characteristics Following Modification of Linear Polyethylenimine with Various Anhydrides

Fu,

Moiseev,

Hyder

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

show abstract

Ionic liquids-assisted integration of biobased materials for sustainable elaboration of nanocomposites using hydroxyethyl cellulose and interlayered clay for efficient separation of Co(II) from multi-component mixtures

Achalhi,

El Ouardi,

Virolainen

et al. 2024

Cellulose

View full text Add to dashboard Cite

This study focuses on the development of eco-friendly biobased adsorbents through a sustainable hydrothermal and freeze-drying synthesis process, utilizing cost-effective bio-sourced materials to minimize energy consumption and waste. The biobased adsorbents were elaborated using hydroxyethyl cellulose-ionic liquids and bentonite clay. The elaborated biocomposites were characterized using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy/attenuated total reflection (FTIR/ATR), thermogravimetric analysis (TGA), and electron microscopy-energy dispersive X-ray (SEM–EDX), Brunauer–Emmett–Teller (BET) and zeta potential (ZP). Structural analysis confirms the intercalation and incorporation of HEC-ILs polymeric chains into Be-Na matrix and the formation of biocomposites. The [HEC-ILs/Be-Na] composite was subsequently employed for solid-phase extraction of Co(II) by investigating the effect of pH, initial Co(II) concentrations, time, temperature, and the presence of co-existing ions (Na(I), Li(I), Mn(II), Ni(II), and Al(III)). The adsorption kinetics of Co(II) metal ions were suitably characterized using the pseudo-second-order model (with R2 > 0.99). Furthermore, the adsorption isotherms conformed to the Langmuir model (with R2 > 0.97), suggesting a chemisorption process with an adsorption capacity of 69.8 mg/g. The thermodynamic study reveals that the adsorption process exhibits characteristics of spontaneity and endothermicity (ΔH° = 74.197 kJ mol−1, ΔG° < 0 kJ mol−1). The proposed mechanism for Co(II) adsorption on the developed biocomposite involves electrostatic interactions, ion exchange, and anion-π interactions. The biobased composite exhibited remarkable selectivity for Co(II) and demonstrated great potential as an adsorbent for industrial applications. Graphical abstract

show abstract

Montmorillonite clay modified by CuFe2O4 nanoparticles, an efficient heterogeneous catalyst for the solvent-free microwave-assisted synthesis of 1,3-thiazolidin-4-ones

AL-Abayechi,

Al-nayili,

Balakit

2024

Res Chem Intermed

View full text Add to dashboard Cite

Advanced materials based on montmorillonite modified with poly(ethylenimine) and poly(2-methyl-2-oxazoline): Experimental and DFT study

Cited by 8 publications

References 58 publications

Exploring Mucoadhesive and Toxicological Characteristics Following Modification of Linear Polyethylenimine with Various Anhydrides

Exploring Mucoadhesive and Toxicological Characteristics Following Modification of Linear Polyethylenimine with Various Anhydrides

Ionic liquids-assisted integration of biobased materials for sustainable elaboration of nanocomposites using hydroxyethyl cellulose and interlayered clay for efficient separation of Co(II) from multi-component mixtures

Montmorillonite clay modified by CuFe2O4 nanoparticles, an efficient heterogeneous catalyst for the solvent-free microwave-assisted synthesis of 1,3-thiazolidin-4-ones

Contact Info

Product

Resources

About