Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis

Nistri, Riccardo; Ianniello, Antonio; Pozzilli, Valeria; Giannì, Costanza; Pozzilli, Carlo

doi:10.3390/diagnostics14111120

Diagnostics

2024

DOI: 10.3390/diagnostics14111120

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Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis

Riccardo Nistri,

Antonio Ianniello,

Valeria Pozzilli

et al.

Abstract: Brain and spinal cord imaging plays a pivotal role in aiding clinicians with the diagnosis and monitoring of multiple sclerosis. Nevertheless, the significance of magnetic resonance imaging in MS extends beyond its clinical utility. Advanced imaging modalities have facilitated the in vivo detection of various components of MS pathogenesis, and, in recent years, MRI biomarkers have been utilized to assess the response of patients with relapsing–remitting MS to the available treatments. Similarly, MRI indicators… Show more

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Cited by 2 publications

References 175 publications

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Is there any connexion amid clinico-radiological outcomes in r-RMS diseased conditions: A study with DTI and MR Imaging – Part I

Raju

2024

IJN

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: Multiple—sclerosis (MS) is a continual, persistent and repetitive disease pretending the central nervous system(CNS) characterized by recurring and reiterated occurrences of neuronal issues which are subsequently decrease stages. The prevalent MS is termed as Reverting (regressive, or relapsing)-remitting MS, i.e., r-RMS, in which, diseased encounter a cycle-of-symptom(CoS) eruptions (or flare-ups) plus successive resurgence cycles or episodes. : To find the correlation among the clinical plus radiological findings in revert, also implement through degenerating MS diseased conditions remittently. : Thirty subjects with their mean—value(±SD) of 28.27(±6.85) years (age ranging as of 18-40), male - female, who were diagnosed as R-RMS (as per Mc Donald criterion). DTI/f-MRI tools were applied for finding the brains anatomical/structural at micro-nano-levels and functional changes underlying the clinical manifestations-of MS. : The percentage-of revert (or relapse, RR) plus lesional weight were correlated at baseline, following a year plus next 2years, there was more RRs correlated with greater lesional-weight(load, statistically significant,P≤0.0037), visual system affection, plus score-of-EDSS as snowballing lesional-weight of MS plaques were allied with cumulation (EDSS-score:p<0.029). There was no correlation(p≤0.029) amongst RR, pyramidal-warmth, cervical, cerebellar—sphincteric, ‘brain-stem’ followed by superficial sensory-motor systems. Significant correlations were found amid scores-of- EDSS and many diffusion-tensor-imaging(DTI) limits(parameters) within the usual-seeming grey matter plus areas-of-lesions(or plaques), signifying that DTI might detect anatomical-structural subcortical changes at microlesion-levels and deep brain structures variations analogous to ‘clinical—disability’. DTI changes were also seen in brain-regions (corpus-callosum, frontal-lobes, cerebellum, cingulum, plus corticospinal-tracts) which were correlated in larger RRs plus higher disability. : DTI/f-MRI tools giving insights at the brains anatomical/structural at micro-nano-levels and functional changes underlying the clinical manifestations-of MS. Our findings features, pinpoints and highlights composite connections amid lesion issue, neural-deficits, also gray-matter (integrity) reliability that develops throughout the disease-course.

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Is there any connexion amid clinico-radiological outcomes in r-RMS diseased conditions: A study with DTI and MR Imaging – Part I

Raju

2024

IJN

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Differential Analysis of Venous Sinus Diameters: Unveiling Vascular Alterations in Patients with Multiple Sclerosis

Tunç,

Danisan,

Taydas

et al. 2024

Diagnostics

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Background: Alterations in the cerebral venous system have been increasingly recognized as a significant component of the pathophysiology of multiple sclerosis (MS). This study aimed to explore the relationship between venous sinus diameter and MS to understand potential vascular alterations in MS patients compared with controls. We sought to determine whether these alterations were correlated with disease characteristics such as duration, lesion type, and disability score. Methods: This study included 79 MS patients diagnosed according to the 2017 McDonald criteria and 67 healthy individuals. Magnetic resonance imaging (MRI) scans via a 1.5 Tesla system provided measurements of the superior sagittal sinus, right and left transverse sinus, sinus rectus, and venous structures. Statistical analysis was conducted via SPSS, employing independent sample t tests, ANOVA, chi-square tests, and Pearson correlation analysis, with the significance level set at p < 0.05. Results: This study revealed significant differences in venous sinus diameter between MS patients and controls, with MS patients exhibiting larger diameters. Specifically, patients with brainstem and spinal lesions had larger diameters in certain sinus regions. No significant correlations were found between venous sinus diameter and demographic factors, expanded disability status scale scores, or lesion counts. However, a significant increase in perivenular lesions was noted in patients with longer disease durations. Conclusions: The findings indicate notable vascular alterations in MS patients, particularly in venous sinus diameters, suggesting a potential vascular component in MS pathology. The lack of correlation with conventional clinical and MRI metrics highlights the complexity of MS pathology. These insights underscore the need for further research, particularly longitudinal studies, to elucidate the role of venous changes in MS progression and their potential as therapeutic targets.

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Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis

Cited by 2 publications

References 175 publications

Is there any connexion amid clinico-radiological outcomes in r-RMS diseased conditions: A study with DTI and MR Imaging – Part I

Is there any connexion amid clinico-radiological outcomes in r-RMS diseased conditions: A study with DTI and MR Imaging – Part I

Differential Analysis of Venous Sinus Diameters: Unveiling Vascular Alterations in Patients with Multiple Sclerosis

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