Advanced nano-based strategies for mRNA tumor vaccine

Qu, Yanlin; Xu, Jingjing; Zhang, Tong; Chen, Qinjun; Sun, Tao; Chen, Jiang

doi:10.1016/j.apsb.2023.07.025

Cited by 9 publications

(3 citation statements)

References 98 publications

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“…mRNA is a highly fragile macromolecule, which is easily degraded by various hydrolytic enzymes in physiological environments. Therefore, mRNA significantly depends on delivery systems to promote its entry into target cells. − Due to the substantial negative charge carried by mRNA, the encapsulation of mRNA can be accomplished by electrostatic adsorption with cationic carriers Figure b lists 10 common delivery systems, such as lipid nanoparticles (LNPs), cationic liposomes, cationic polymers, cationic nanoemulsions, polymer micelles, etc.…”

Section: Mrna Technologymentioning

confidence: 99%

Emerging mRNA Technology for Liver Disease Therapy

Wang,

Fang,

Luo

et al. 2024

ACS Nano

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Liver diseases have consistently posed substantial challenges to global health. It is crucial to find innovative methods to effectively prevent and treat these diseases. In recent times, there has been an increasing interest in the use of mRNA formulations that accumulate in liver tissue for the treatment of hepatic diseases. In this review, we start by providing a detailed introduction to the mRNA technology. Afterward, we highlight types of liver diseases, discussing their causes, risks, and common therapeutic strategies. Additionally, we summarize the latest advancements in mRNA technology for the treatment of liver diseases. This includes systems based on hepatocyte growth factor, hepatitis B virus antibody, left−right determination factor 1, human hepatocyte nuclear factor α, interleukin-12, methylmalonyl-coenzyme A mutase, etc. Lastly, we provide an outlook on the potential of mRNA technology for the treatment of liver diseases, while also highlighting the various technical challenges that need to be addressed. Despite these difficulties, mRNA-based therapeutic strategies may change traditional treatment methods, bringing hope to patients with liver diseases.

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Section: Mrna Technologymentioning

confidence: 99%

Emerging mRNA Technology for Liver Disease Therapy

Wang,

Fang,

Luo

et al. 2024

ACS Nano

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“…In recent years, liposomes play a critical role as essential components of COVID-19 mRNA vaccines for protecting the mRNA . Similarly, for tumor mRNA vaccines, liposomes can also act as a delivery vehicle and play a protective role …”

Section: Delivery Systems For Tumor Vaccinesmentioning

confidence: 99%

“…184 Similarly, for tumor mRNA vaccines, liposomes can also act as a delivery vehicle and play a protective role. 185 5.2. Cell Membrane Vesicles.…”

Section: Delivery Systems For Tumor Vaccinesmentioning

confidence: 99%

Components, Formulations, Deliveries, and Combinations of Tumor Vaccines

Liu,

Yao,

Sun

et al. 2024

ACS Nano

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Tumor vaccines, an important part of immunotherapy, prevent cancer or kill existing tumor cells by activating or restoring the body's own immune system. Currently, various formulations of tumor vaccines have been developed, including cell vaccines, tumor cell membrane vaccines, tumor DNA vaccines, tumor mRNA vaccines, tumor polypeptide vaccines, virus-vectored tumor vaccines, and tumor-in-situ vaccines. There are also multiple delivery systems for tumor vaccines, such as liposomes, cell membrane vesicles, viruses, exosomes, and emulsions. In addition, to decrease the risk of tumor immune escape and immune tolerance that may exist with a single tumor vaccine, combination therapy of tumor vaccines with radiotherapy, chemotherapy, immune checkpoint inhibitors, cytokines, CAR-T therapy, or photoimmunotherapy is an effective strategy. Given the critical role of tumor vaccines in immunotherapy, here, we look back to the history of tumor vaccines, and we discuss the antigens, adjuvants, formulations, delivery systems, mechanisms, combination therapy, and future directions of tumor vaccines.

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Engineered mRNA Delivery Systems for Biomedical Applications

Wang,

Zhu,

Gan

et al. 2024

Advanced Materials

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Messenger RNA (mRNA)‐based therapeutic strategies have shown remarkable promise in preventing and treating a staggering range of diseases. Optimizing the structure and delivery system of engineered mRNA has greatly improved its stability, immunogenicity, and protein expression levels, which has led to a wider range of uses for mRNA therapeutics. In this tutorial review, we first provide a thorough analysis of the optimization strategies used in the structure of mRNA and then describe delivery systems in great detail. Furthermore, we summarize the latest advancements in biomedical engineering for mRNA technology, including its applications in combatting infectious diseases, treating cancer, providing protein replacement therapy, conducting gene editing, and more. Lastly, we offer a perspective on forthcoming challenges and prospects concerning the advancement of mRNA therapeutics. Despite these challenges, mRNA‐based therapeutics remain promising, with the potential to revolutionize disease treatment and contribute to significant advancements in the biomedical field.This article is protected by copyright. All rights reserved

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Advanced nano-based strategies for mRNA tumor vaccine

Cited by 9 publications

References 98 publications

Emerging mRNA Technology for Liver Disease Therapy

Emerging mRNA Technology for Liver Disease Therapy

Components, Formulations, Deliveries, and Combinations of Tumor Vaccines

Engineered mRNA Delivery Systems for Biomedical Applications

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