Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Zhu, Yanting; Zhang, Chenwei; Liang, Ying; Shi, Jianyuan; Yu, Qiuhao; Liu, Shen; Yu, Dengguang; Liu, Hui

doi:10.1039/d3bm02038j

Cited by 20 publications

(8 citation statements)

References 215 publications

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“…The physical states of raw materials and nanofibers can be determined using XRD, which is important for the presence and exerting functional performance of the loaded active ingredients [86][87][88][89]. From XRD patterns in Figure 6a, the untreated PCL has two typical sharp peaks at 21.25 • and 23.50 • .…”

Section: Physical States and Compatibilitymentioning

confidence: 99%

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

Huang,

Wang,

et al. 2024

Nanomaterials

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Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery. Herein, several new kinds of medicated nanofibers loaded with several active ingredients for providing multiple functions were prepared using the modified coaxial electrospinning processes. With an electrospinnable solution composed of polycaprolactone and fenoprofen as the core working fluid, several different types of unspinnable fluids (including pure solvent, nanosuspension containing tranexamic acid and hydroxyapatite, and dilute polymeric solution comprising tranexamic acid, hydroxyapatite, and polyvinylpyrrolidone) were explored to implement the modified coaxial processes for creating the multifunctional nanofibers. Their morphologies and inner structures were assessed through scanning and transmission electron microscopes, which all showed a linear format without the discerned beads or spindles and a diameter smaller than 1.0 μm, and some of them had incomplete core–shell nanostructures, represented by the symbol @. Additionally, strange details about the sheaths’ topographies were observed, which included cracks, adhesions, and embedded nanoparticles. XRD and FTIR verified that the drugs tranexamic acid and fenoprofen presented in the nanofibers in an amorphous state, which resulted from the fine compatibility among the involved components. All the prepared samples were demonstrated to have a fine hydrophilic property and exhibited a lower water contact angle smaller than 40° in 300 ms. In vitro dissolution tests indicated that fenoprofen was released in a sustained manner over 6 h through a typical Fickian diffusion mechanism. Hemostatic tests verified that the intentional distribution of tranexamic acid on the shell sections was able to endow a rapid hemostatic effect within 60 s.

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Section: Physical States and Compatibilitymentioning

confidence: 99%

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

Huang,

Wang,

et al. 2024

Nanomaterials

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“…Initially, electrospinning is termed as electrostatic spinning because it is exploited for preparing fibers from polymer solutions or melts (Zhu et al, 2024), just as some other traditional spinning techniques in the textile field such as wet spinning, dry spinning, wet-dry spinning and blow spinning (Ahmed et al, 2024;Chen, Zhou, et al, 2023). With the surge of nanoscience, electrospinning is creeping out from the textile field, and spread into almost all the applied scientific fields such as energy, environment, and medicine (Bai et al, 2022;Cao & Ding, 2022;Song et al, 2022).…”

Section: The Developments Of Ehda On Creating Shapesmentioning

confidence: 99%

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Yu,

Gong,

Zhou

et al. 2024

WIREs Nanomed Nanobiotechnol

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The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro‐/nano‐particles, and beads‐on‐a‐string hybrids. They can be further divided into different kinds of sub‐shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH‐sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape–performance relationships at nanoscale, besides the size, inner structure and the related structure–performance relationships, would further play their important roles in promoting the further developments of drug delivery field.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…42–45 Biphasic release, as an advanced type of rate-controlled drug release, has demonstrated its value in treating several kinds of diseases with some commercial products. 46–49 Among the different sorts of biphasic release profiles, the one with an initial fast release and a second sustained release represents the most popular case. Electrospun nanofibers (composed by blending a soluble polymer with an insoluble polymer with Janus and core–shell structures and even tri-layer structures) have demonstrated their capability in these special applications.…”

Section: Introductionmentioning

confidence: 99%

“…However, these hybrid structures (with beads around one side of the fibers and core–shell beads randomly distributed all over the fibrous mats) were verified to be useful for providing the desired biphasic release. 46–51 Meanwhile, the different organizations of fibrous mats can open new ways of developing DDSs with biphasic release, such as the integration of an electrospun film for fast release, casting a solid film for sustained release, and employing a sandwich structure with outer layers for fast release and an inner layer for extended release. 52 Although these strategies have been reported, there have been no reports about biphasic release from Janus particles.…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

Zhou,

Pan,

Gong

et al. 2024

Nanoscale

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Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Abstract: Tissue adhesion is one of the most common postoperative complications, which are frequently accompanied by inflammation, pain, and even dyskinesia, significantly reducing patients´ life quality. To prevent the formation of...

Cited by 20 publications

References 215 publications

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

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